Tag: "dose" at biology news

Wake Forest scientists find new combination vaccine effective against plague

... combination vaccine were challenged with a lethal dose of Yersinia pestis, the bacterium that causes plague, "the immune mice survived but the control mice succumbed in three days." Mizel and his graduate student, Anna Honko, found that injecting a protein taken from plague bacteria into a mouse one met...

Secret of smallpox's success may lead to bioterror cure

...cinia virus and then is vaccinated with a very low dose of the mutant virus only 100 virus particles the mouse gets sick but eventually recovers. The more mutant virus the mice are given, the less sick they become. "If you give them a million particles, they don't even get sick -- the animals stay healt...

Liver transplant patients gain same benefits from CellCept as kidney transplant patients

...Optimal kidney function CellCept taken with a low dose of tacrolimus showed a trend towards improved kidney function (Abstract 1240). CellCept is proven to promote excellent kidney function early after kidney transplantation in renal patients taking tacrolimus(1) Less liver fibrosis recipients taki...

Cancer survivors may be at higher risk for cognitive dysfunction

...n and the patient," Meyerowitzsaid. "Maybe a lower dose might be useful for the cancer but wouldreduce risk of cognitive dysfunction." "Those with cancer might also be advised to have their cognitionmonitored as part of long-term follow-up," added Margaret Gatz,professor of psychology at USC and foreign a...

Genetic variation alters response to common anti-clotting drug

...t attack, stroke, or major surgery. But the proper dose of warfarin can vary greatly and can be hard to pr...plain why certain people require a lower or higher dose of warfarin to get its full benefits. This line of work ultimately could help doctors determine each...

Experts hope policy breathes life into asthma treatment method

...larger than an inhaler dose, even when the inhaler dose is doubled, she said. "You put a lot more drug in...g," she said. "(Patients) can get a more effective dose from a (metered-dose inhaler) and holding chamber."...

GroPep infertility data presented at US meeting

...k's research found that administration of a single dose of the GroPep drug PV903 halved the miscarriage rate in a strain of female mice susceptible to the immune rejection of the foetus (a suspected major cause of recurrent miscarriage in women). Scientists believe that women who suffer from repeated mis...

Positive effects of nuclear medicine, 'smart drugs' provide hope for non-hodgkin's lymphoma patients

...eutic regimen, a patient receives an injected test dose of the antitumor monoclonal antibody-- tositumomab...ly radiation disappears from a patient's body. The dose given to each patient is individualized to the patient's own handling of the drug, so the patient re...

Experimental vaccine protects nonhuman primates from Lassa fever

... then immunized four rhesus macaques with a single dose of the Lassa vaccine, while two monkeys received o...animals were experimentally infected with a lethal dose of Lassa virus. The four vaccinated monkeys survived with no signs of clinical illness, while the tw...

Prescription pain patch abuse blamed for increase in deaths

...misusing a clear patch that transfers a controlled dose of fentanyl through the skin into the bloodstream ...ng on the drug were able to easily remove the full dose of fentanyl from the patch and take the entire three-day amount at once, either by injecting, ingest...

Targacept compounds show long-lasting improvement in cognition

...be able to achieve efficacy with a low, once-daily dose that minimizes side-effects. A simple, daily dosing regimen is particularly important when treating disorders that affect cognition," he added. "Targacept's compounds act selectively on nicotinic acetylcholine receptor targets, and we anticipated thi...

New study suggests role for clazosentan in the prevention of cerebral vasospasm after aneurysmal SAH

...achnoid hemorrhage) will analyse the efficacy of 3 dose levels of clazosentan in preventing the occurrence of cerebral vasospasm following SAH, assessed by angiography. As a secondary endpoint, the study will also assess the ability of clazosentan to reduce the occurrence of early morbidity/mortality as ...

Interim data suggest major response with Aranesp(R) in anemic patients with MDS

...d to for target and maximum hemoglobin levels, and dose adjustment rules should be performed in line with regional prescribing information. In a study of Epoetin alfa-treated hemodialysis patients with clinically evident cardiac disease, where the target Hct was 42% (Hb =14 g/dL), an increased incidence o...

Inhaled nitric oxide protects premature infants' brains

...ch more testing needs to be done. Even the optimal dose and duration of nitric oxide treatment are unknown. "Those will be our next steps," Schreiber said. Meanwhile, the researchers will continue to follow children from the original study until they reach age 5 to assess their progress in kindergarten an...

Tufts nutrition scientists say it is premature to focus on nutrient supplements over diet

...ir nature very complex. Within the context of high dose nutrient supplementation, outcomes are frequently ... that some of the unanticipated findings from high dose single or nutrient cocktails may be because the levels used are much higher than those necessary to ...

One hit of crystal meth causes birth defects: U of T study

A single prenatal dose of methamphetamine commonly known as speed may b...s Wells. "It's pretty remarkable that a single low dose can have such an effect. "It's an important finding, given the increasing use of club drugs among wo...

MIT engineers an anti-cancer smart bomb

...into a tumor, seal the exits and detonate a lethal dose of anti-cancer toxins, all while leaving healthy cells unscathed. MIT researchers have designed a nanoparticle to do just that. The dual-chamber, double-acting, drug-packing "nanocell" proved effective and safe, with prolonged survival, against two ...

Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

...ies that protected them from many times the lethal dose of the bacteria. "Our data, the authors conclude, "provide the first evidence of plague vaccines that do not suppress innate immune responses and that may be useful for plague vaccination in animals, and, perhaps, humans." The next steps include te...

Changes in technique can reduce radiation dose in CT examination

...que could make a major difference in the radiation dose used in survey CT scans, a new study shows. Surve...usually to plan for the examination. The radiation dose in a survey scan can be as high as that of four chest X-rays, said Dianna D. Cody, PhD, associate pr...

Taking a break from fractures: A closer look at vitamin D

...nter on Aging at Tufts University, found that this dose was not effective in reducing nonvertebral fracture rates among study participants. The researchers concluded, though, that higher daily doses, in the range of 700 to 800 IU, may reduce the risk of fracture by approximately 25 percent. Dawson-Hugh...

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(Date:7/30/2014)... Wallerian degeneration is a subject of major interest ... differentially regulated during the distinct stages of Wallerian ... differentiation and dedifferentiation. Although gene expression responses in ... peripheral nerve injury are known, differences in gene ... unclear. Dr. Dengbing Yao and co-workers from Nantong ...
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