Tips from the Journals of the American Society for Microbiology
...istered to mice that were challenged with a lethal dose of the EHEC strain 55 days later. A single dose of the vaccine resulted in an 86 percent protection rate and mice receiving a booster after 28 days ...Metal-based medicine could treat diseases in the body
..., eventually destroying many targets. So a smaller dose of a metal complex could do the work of a larger dose of a traditional drug. Completely destroying the target molecule also lowers the chance that a virus...A new player in the battle against hepatitis prevents inflammation and the death of liver cells
...colleagues from this team have shown that an extra dose of ABIN-1 provides a double protection to liver cells in mice. With an elevated production of ABIN-1, this protein will neutralize the inflammation caused by NF-B and also prevent the complete death of liver cells after induction by TNF. ABIN-1 in t...Chernobyl: The true scale of the accident
...inated areas, exposures are within the recommended dose limit for the general public, though about 100,000 residents still receive more. Remediation of those areas and application of some agricultural countermeasures continues. Further reduction of exposure levels will be slow, but most exposure from the ...UCSD study of nuclear receptors could change anti-inflammatory treatments
...h negative side effects, could be given at a lower dose along with different drugs targeting the other receptors. For example, one class of potent corticoid drugs used to treat severe asthma has many negative side effects, including high blood pressure, diabetes and obesity. "What is of particular intere...$25 million NIH grant funds new technologies for rapid mass screening of radiation exposure
...ned to have the most potential for high-throughput dose assessment: Project 1: Rapid Tissue Analysis Design and construction of a new device that will use advanced, high-speed automated image analysis and robotics to quickly examine tissue samples (e.g., a fingerstick of blood) for quantitative indicator...Blood test for colon cancer risk to be goal of Hopkins project
...sts reported in February that, in mice, the double dose of IGF-2 protein sets the stage for cancer development -- by increasing the number of primitive cells found in the colon -- and that early evidence suggests the same could be true in people. "If everything works out -- if IGF-2 status is tied to col...Old drug shows new promise for Huntington's Disease
...t's a limited study, in that we used the same drug dose on all the animals as opposed to comparing different doses, but fairly convincing," Massa concluded. "Together, the in vitro and in vivo results suggest that Clioquinol has an effect of decreasing the symptoms of Huntington's, its pathology, and perh...Alcoholics have a greater chance of infection following cardiac surgery
...all a matter of dose. Researchers recommend a low dose of alcohol, such as one glass of red wine per day, to prevent myocardial infarction but three bottles of beer per day has been proven to harm the body. In particular, it weakens the immune system, which every operative patient needs in order to fig...Sitagliptin, a new investigational treatment for type 2 diabetes, may offer new hope for patients
...n in patients randomized to the 100 mg once daily dose of sitagliptin using data carried forward, that is...Longer term studies with an appropriate once daily dose of sitagliptin will address the full efficacy and potential durability of sitagliptin versus glipizi...Cytokinetics presents data on CK-1827452
...rial is designed to identify the maximum tolerated dose of a 6-hour intravenous infusion of CK-1827452. The effect of CK-1827452 on the left ventricular function of these healthy volunteers will be evaluated using serial echocardiograms. The cross-over design of this clinical trial will ensure that each...Gaining ground in the race against antibiotic resistance
...yme that allowed the bacteria to survive on a drug dose 64 times higher than the dose that kills bacteria hosting the un-evolved enzyme. "We were mimicking what is going on in the doctor...Study in Royal Society journal on possiblity of human organ regeneration
...ts and one month later re-infected with a standard dose of parasites. One year later males with increased testosterone levels had greater parasite intensities than controls. This interaction within individuals has the potential to affect the unstable population dynamics of red grouse. Contact: Dr LJ Seiv...Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease
...ave undergone gene transfer, four in each of three dose cohorts. Seven of the eight patients representing...to be efficacious, as well as safe, at the current dose levels." This Phase I trial is the culmination of more than 10 years of basic research. In 1994, Dr...Structures of marine toxins provide insight into their effectiveness as cancer drugs
...lls. Moreover, initial work shows that even a low dose of these toxins can bring a significant response." Prior to the study published in PNAS, it was known that the marine toxins affect several forms of cancer - but not how they worked, says Rayment. The recent findings will enable the toxins to be syn...Biodesign Institute and TGen awarded grants to help lessen threat of radiological terrorist event
...ilian and military populations when exposed to low dose radiation of a dirty bomb or other environmental r...exposure method available to measure the radiation dose received by individuals in the event of a large-scale scenario. Current technologies can assess only...Breakthrough technology from Pall increases platelet availability and safety
...dose SM Platelets, a transfusion-ready therapeutic dose of platelets that is both leukoreduced and bacteria tested with a highly sensitive culture based method. In turn, hospitals can reduce their handling costs by eliminating the need for further processing and testing. "This is a seminal advance in blo......roduct that blocks the enzymes and then delivers a dose of pesticide 4-5 hours later to kill the newly defenceless insect. The technique uses piperonyl butoxide (PBO), a chemical derived originally from the sassafras tree and used for many years in laboratories to enhance the effectiveness of other chemic...Vanadium appears to play role in speeding recovery from infections
...n their research, Johnson first administered a low dose of lipopolysaccharide (LPS), a molecule present on E. coli and other gram-negative bacteria, to both diabetic and non-diabetic mice after they had been given IGF-1. Non-diabetic mice recovered more quickly than diabetic mice, suggesting, he said, an......re that a young girl, provided with a prophylactic dose of the drug after experiencing mild influenza symptoms, developed a strain of the virus that was highly resistant to the drug. The finding suggests that health officials - now stockpiling millions of doses of the drug to forestall a global outbreak o...