Gene therapy may protect normal tissues during radiation retreatment for lung cancer
...found that in mice that received the initial 14 Gy dose there was 50 percent survival at 180 days (due to ... Mice that received MnSOD-PL before both the 14 Gy dose as well as the subsequent 10 Gy dose had the best survival rate overall. Mice treated with MnSOD-PL ...Improved blood safety measures from Pall can increase platelet availability
...ests) prior to pooling into a standard therapeutic dose for transfusion. However, if whole blood derived ... significant benefits such as having a therapeutic dose ready in emergency situations, reducing pool outdating, and enabling a simplified method for bacteri...Cytori demonstrates adipose stem cells improve cardiac function in preclinical heart attack model
...ndergo multiple cell divisions to achieve a target dose of cells, and were harvested and administered on the day of the heart attack. The results of the study, conducted in collaboration with Tulane University, were presented at the 17th annual Transcatheter Cardiovascular Therapeutics 2005 conference in ...Whooping cough vaccine not just for kids anymore
...ecommended that all 11 and 12 year olds be given a dose of this new pertussis vaccine as a combined formulation with tetanus and diphtheria boosters. Recommendations for immunization of older adults are under active review. Barenkamp said another purpose of the study was to gather data on the true incid...Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy
...d respiratory failure. After injecting a very high dose of AAV-8 carrying a normal copy of the delta-sarcoglycan gene intravenously into 10-day-old and adult LGMD hamsters, Dr. Xiao and his colleagues found that it had been systemically incorporated into skeletal, diaphragm and cardiac muscle cells in bot...International consortium completes map of human genetic variation
...help doctors prescribe the right drug in the right dose for each patient, as well as recommend prevention strategies that take into account individuals' varying responses to environmental factors, such as diet. Also, the HapMap may be used to find genetic factors that contribute to good health, such as th...Modifications render carbon nanotubes nontoxic
... non-cytotoxic. While cell death did increase with dose concentration, cell death never exceeded 50 percent for these compounds, which were each tested to a level of 2,000 parts per million. Just as with buckyballs, CBEN found that higher degrees of surface modification led to lower toxicity for SWNTs. "W......mized to receive either a once-monthly maintenance dose of certolizumab 400 mg or placebo. Clinical response was defined as a 100 point drop in the Crohn's Disease Activity Index (CDAI), which measures the disease severity by taking into account a number of factors such as intensity of symptoms, medicati...UV measurement tool aids defense against microbes in tap water
... use of fluorescent microspheres to measure the UV dose distribution will augment earlier devised methods for characterizing UV systems, thereby raising confidence in the reactors' ability to combat health threats in the water supply, Linden said. Traditional methods simply test disinfection by spiking a ...Travelers can avoid jet lag by resetting their body clocks
... was a slightly larger phase shift with the 3.0 mg dose compared to the 0.5 dose; however, the difference ...ly significant. In addition, the higher melatonin dose made the participants slightly more sleepy in the evenings after taking the pill. Therefore, the re...New ECCO 13 data emphasise vital importance of cervical cancer detection, treatment and prevention
...at was found to be significant was the teletherapy dose patients received this was associated with significant inter-country variability. Lowest levels were recorded in Zimbabwe (mean 22.4 Gy) where a machine breakdown actually resulted in 10 registered patients not receiving any radiotherapy whatsoever ...New treatment options for patients with prostate cancer
.... These groups were treated with either the higher dose of radiotherapy at 78Gy or the conventional dose at 68Gy. Some of the patients from the intermediate and high risk groups were also receiving hormona...New ECCO studies highlight promising potential of cancer immunotherapy
...ared to the standard therapy of renal cancer (high dose interleukin-2) which produced a median progression...edian overall survival, patients treated with high dose interleukin-2 survived 17.5 months1 and those treated with the LMI vaccine survived longer than 17.0...Brainstem blocks pain to protect key behaviors
...It's as if they could give themselves a six-second dose of morphine, allowing hunger to override pain." Mason and colleague Hayley Foo, research associate in NPP, studied adult male rats in containers with a wire mesh floor that enabled them to deliver radiant heat to one hind paw. The heat caused no dam...Alcohol, stress, a family history of alcoholism, and the β-endorphin system
...is said that a specific response may depend on the dose of alcohol as well as the species involved. "For example, in experimental animals such as rats, all doses of alcohol increase the release of β-endorphin," she said. "However, in humans low doses of alcohol have either no or a small effect on &...Innovative research set to push boundaries of cancer care
...tely 18-30 patients with advanced melanoma at five dose levels. The current dose (3rd dose level) being tested is five times higher than the first dose tested. Thus far there has be...New antimalarial combination confirms its potential use in treating drug-resistant malaria
...rum malaria, was designed to determine the optimum dose of artesunate in combination with LapdapTM (chlorproguanil/dapsone). Treatment with CDA, at three doses of artesunate (1, 2 and 4mg/kg) in adults and at two doses (2 and 4mg/kg) in children, led to faster time to reduce parasite levels in the blood b...Recycled or revamped therapeutics find novel anti-cancer applications
...s, which are considered very low in pharmaceutical dose ranges for therapeutics. For the drugs to be beneficial in clinical applications of human pancreatic cancer patients, MAPT expression levels will have to be an integral component of the proteomic profile of a sub-group of all human pancreatic cancer...ADHD medication might also treat hyperactivity symptoms in autism
...nsure that subjects could tolerate three different dose levels of the medication, followed by a four-week ... dose. Children showing a positive response to any dose during the crossover phase were treated for an additional eight-week period to ensure the gains were......asten the development of a fetus's lungs. A single dose cuts the death rate of such babies by up to 40 per...s that the side effects might not happen after one dose of the drug. A study earlier this year looking at 31-year-olds whose mothers had been given just one...