Tag: "dose" at biology news
Accentia Biopharmaceuticals acquires exclusive license
... , a unique, patented delivery device for metered dose
inhalers used to treat asthma and chronic obstructive pulmonary disease. In addition, our pipeline includes an intranasal antifungal which we are developing for chronic sinusitis under an Investigational New Drug Application (IND)"....
Mouse study: New muscle-building agent beats all previous ones
... muscle growth after just two weeks at the highest dose
given (50 milligrams per kilogram mouse weight). D... just one week, mice given a fifth of that highest dose
had muscles 16 percent to 25 percent bigger than untreated mice, depending on the muscle group analy...
Data in New England Journal of Medicine show benefits of REMICADE in ulcerative colitis patients
...aseline. The baseline median daily corticosteroid dose
was 20 mg/day in both studies. Of the patients who were receiving corticosteroids at baseline, the proportion of patients who were in clinical remission and had discontinued corticosteroids was significantly greater in the 5 mg/kg REMICADE group ver...
Study shows combination of immune substances to be safe
...t IL-12 primes white blood cells such that a lower dose
of interferon will stimulate the same level of immune activity as a higher dose
of interferon when used alone. The results come from a phase-I clinical trial, which marks the firs...
Pramipexole delivered sustained efficacy in clinical trial of patients with Restless Legs Syndrome
... treatment of RLS has been studied from a starting dose
of 0.125mg single dose
per day and up to 0.75mg single dose
per day. These trials are part of a comprehensive clinical tri...
New data suggest pramipexole relieves symptoms of Restless Legs Syndrome (RLS) and is well-tolerated
...ty of pramipexole has been studied from a starting dose
of 0.125mg single dose
per day and up to 0.75mg single dose
per day. Two pivotal studies of pramipexole in RLS have showed...
New Phase 3 data show potential benefits of Aranesp dosed every three weeks for CIA
... trial assessed the efficacy and safety of a fixed dose
of 300 mcg of Aranesp administered every three wee...Hb increase exceeds 1.0 g/dL in any 2-week period, dose
reductions are recommended. In a study with another erythropoietic product, where the target Hb was...
Interim long-term follow-up data show AMG 531 increases platelets in patients with ITP
...t AMG 531 administered as an individualized weekly dose
resulted in a durable platelet response. If appro...ent and 25 percent (n=2) had at least a 50 percent dose
reduction. "It is exciting that most patients in this study achieved platelet counts of greater than...
Interim Aranesp data suggest major response in anemic patients with MDS
...Hb increase exceeds 1.0 g/dL in any 2-week period, dose
reductions are recommended. In a study with another erythropoietic product, where the target Hb was 12 - 14 g/dL, an increased incidence of thrombotic events, disease progression, and mortality was seen. Pure red cell aplasia (PRCA) has been observ...
Hearing loss from chemotherapy underestimated
...a. The main aim is to determine a safely tolerated dose
of NAC in humans. Once the safe dose
is determined, Phase 2 efficacy testing begins to see if NAC, combined with STS, will protect hearin...
Alcohol-induced bone disease
...per day was generally greater with larger alcohol dose
and/or longer duration of consumption. The dose
and duration effects in experimental models, where a more accurate determination can be made, provid...
Penicillin, amoxicillin: Step aside for strep throat treatment
...rugs is more effective than the traditional 10-day dose
of the older antibiotics. Pediatricians at the University of Rochester Medical Center found that 25 percent of children treated for strep throat with penicillin ended up back in the doctor's office within three weeks of treatment. Children treated wi...
LIAI initiatives battle influenza; Potential bird flu treatment among their findings
...tem." The study also found that a relatively low dose
of the antibodies was needed to fight the various flu strains. While most of the work was done on virus pieces to avoid the risk of using actual viruses, Gemini also tested the M2 antibodies on mice infected with a potentially lethal influenza stra...
Univ. of Chicago researchers license pharmacogenomics test for patients with colorectal cancer to Mayo
...e drugs are most effective at the highest possible dose
yet they are also quite toxic," said Ratain. "But finding the right dose
is difficult because patients vary radically and unpredictably in how they respond to these drugs. ...
New view of cancer: 'Epigenetic' changes come before mutations
...pan reported that mice engineered to have a double dose
of insulin-like growth factor 2 (IGF2) had more primitive precursor cells in the lining of the colon than normal mice. When these mice also carried a colon-cancer-causing genetic mutation, they developed twice as many tumors as mice with normal IGF2 ...
FDA grants REVLIMID NDA approval
...adverse event (AE) and that patients may require a dose
adjustment. Other observed and common AE's include diarrhea, pruritis, rash, fatigue, constipation, nausea, nasopharyngitis, arthralgia, pyrexia, back pain, peripheral edema, cough, dizziness, headache, muscle cramp, dyspnea, and pharyngitis. "Being...
New technique points to safer, more efficient vaccination
...ice immunized with just one-hundredth the standard dose
and induced to overproduce TAP were still able to survive an otherwise lethal viral infection. "We were surprised that over-expression of TAP would have such a great effect because it implies that it is in limiting amounts normally or is inefficien...
Optimal adjuvant radiation therapy associated with improved survival, meta-analysis shows
...where patients received an inadequate or excessive dose
of radiation; and category 3, for studies in which an inadequate amount of tissue was treated with radiation therapy. At 5 years, patients in category 1 studies had a 2.9% absolute increase in survival with radiation therapy than without. At 10 year...
GlaxoSmithKline's rotavirus vaccine candidate shown effective
...date or placebo. From administration of the first dose
until one to three months after administration of the second dose, the entire study population was followed for the assessment of intussusception and serious adverse events. In addition, a subgroup of 20,169 was followed up to one year of age for th...
Component in soy products causes reproductive problems in laboratory mice
...effects at all levels. Mice treated with the high dose
(Gen 50 mg/kg) were infertile and mice treated with lower doses were subfertile, meaning they had fewer pups in each litter, and fewer pregnancies. Mice receiving the highest level of genistein, 50 mg/kg per day, had a high percentage of egg cells t...
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