Brain plays key role in diabetes therapy
...ve blood sugar control while lowering the required dose of the hormone, the researchers said. That advance, in turn, might help to reduce side effects of insulin treatment, such as weight gain, they added. Insulin normally allows body tissues, such as the muscles, to take up the blood sugar glucose, the b...Vaccine provides 100 percent protection against avian flu virus in animal study
... vaccine. The chickens were then challenged with a dose of whole H5N1 virus 10,000 times greater than the dose given to the mice and significantly greater than the dose farm chickens are likely to be exposed to ...Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
...viduals in the group receiving the highest vaccine dose produced ricin-neutralizing antibodies in their bl...ms had responded. Four of five in the intermediate dose group produced antibodies, while one of five in the lowest dose group did so. The human-produced an...A step forward in the fight against bacterial infections
...Ghent researchers administered 10 times the lethal dose of LPS to the mutant mice, without deadly consequences. This finding could not be attributed to an alteration in TLR4, but to a reduced production of type 1 interferons. To verify this, Mahieu and her colleagues administered these interferons prevent...Heparin prepared synthetically could replace animal-derived drug
...fficient to treat humans, says Linhardt. One human dose of heparin is approximately 100 milligrams. Rensselaer and UNC-Chapel Hill researchers successfully synthesized hundreds of milligrams of heparin by developing a large-scale process involving engineered enzymes and co-factor recycling. The new, scale...High resolution 'snapshots' detail dynamics of a cocaine antibody
...hand, has the ability to regenerate after each new dose of the drug, making it far more effective than others in metabolizing cocaine. The study, which will be published in the February issue (Volume 14 Issue 2) of the journal Structure, was led by Ian A. Wilson, D.Phil., of Scripps Research Department of...Genomics-based vaccine could prevent deadly cattle disease
...gens and then gave the cattle a potentially lethal dose of T. parva . When compared with control animals, vaccinated cattle showed significantly stronger immune response to the parasite. "This study is a true milestone," says Fraser-Liggett, president of TIGR. "It's one of the first to take advantage of...VCU study shows Levitra may protect the heart
... time that pretreatment with a clinically relevant dose of Levitra, generically known as vardenafil, induces a protective effect against heart attack injury by opening the mitochondrial KATP channel in an animal model. The Journal of Molecular and Cellular Cardiology is the official publication of the Int...New compound may protect against liver cancer
... compound has a much greater effect at a far lower dose than any other compound currently used for preventing aflatoxin-induced cancer in humans," said Thomas Kensler, Ph.D., a cancer biologist with the Johns Hopkins Bloomberg School of Public Health and lead author on the study. According to Kensler, CDD...Calcium and vitamin D supplements offer modest bone improvements, no benefits for colorectal cancer
...r, women who consistently took the full supplement dose experienced a significant 29 percent decrease in h...000 participants in the CaD trial received a daily dose of 1000 milligrams of calcium carbonate combined with 400 IUs of vitamin D3. The other half of the s...Loud music worsens effects of taking ecstasy
...ecia in Catanzaro, Italy, injected rats with a low dose (3mg/kg) or a high dose (6mg/kg) of MDMA or, in the control group, with saline. The rats were either left without acoustic s...Oncologists could gain therapeutic advantage by targeting telomere protein
...lls, we would be able to kill them with a very low dose of radiation and gain a therapeutic advantage," says senior author Tej K. Pandita, Ph.D., associate professor of radiation oncology and on the faculty of the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital...PNNL recognized for commercializing technology
...o effectively and quickly provide a cancer-killing dose to a tumor. Through collaboration with PNNL researchers and access to the laboratory's facilities, IsoRay Medical, Inc., of Richland, Wash., expanded its cancer therapy technology for treating prostate and other cancers. The cesium-131 brachytherapy ...Researcher tackles complexities of obesity, diabetes and their age-related complications
...ops early or late, quickly or slowly, with a heavy dose of genetic predisposition," she said. Studies support the concept that each person has an age-related "set" point for weight somehow regulated by physiology and genetics. This may help explain why more than 95 percent of dieters who shed 35 extra pou......de-generated signal. Cells pretreated with a lower dose of decadienal before receiving a higher dose had far better survival and growth rates than cells treated with only a single high dose. These resu...Wildlife researchers identify impacts of contamination in amphibians
...ting, where the subject is exposed to a controlled dose of contaminants. However, we were able to look at how these toads are more realistically impacted by contaminants in a natural habitat polluted by human activities," Hopkins notes....Tips from the journals of the American Society for Microbiology
...y thirty healthy human volunteers received an oral dose of a whole-cell P. aeruginosa vaccine and reported...eudostat is safe and immunogenic in humans at this dose and that further studies to determine the appropriate dosage and efficacy are needed." (A.W. Cripps,...Researcher looks for more targeted way to deliver cancer drugs
...t is while simultaneously delivering a therapeutic dose of medicine. Yang's work on the targeted drug delivery system is connected to his research on new ways to neutralize the anticoagulant Heparin. When Heparin is used in surgery to thin the patient's blood, doctors later reverse the process with an an...JCI table of contents, February 23, 2006
...e University of Cincinnati report that while a low dose of allergen is sufficient to activate the IgG/ Fc(gamma)III/ macrophage pathway, high doses of allergen are required to induce IgE/mast cell responses. The authors performed several mouse immunization experiments to demonstrate that the reason for th......he intestines. "Our goal was to increase the tumor dose and lower the systemic dose," said Chilkoti. "Macromolecular drug carriers are an attractive drug delivery system, because they target tumors and have limited toxicity in normal tissues." Of additional benefit, macromolecular drug carriers can be sub...