Time running out for South Asian vultures, ecologists warn
...nts to ban veterinary use of the anti-inflammatory drug diclofenac. Without banning use of the drug in livestock species likely to be eaten by vultures - mainly cattle and buffalo - three species of v...NIH awards new $14.5 million, five-year grant to the Scripps Research Institute
...cules involved in pain signaling, and is a current drug target of several pharmaceuticals companies. Wthrich and his colleagues applied NMR to membrane proteins suspended in large soap-like micelles, which mimic the membrane and preserve the fold of the proteins. "You can't do conventional NMR on such t...New therapy for specific form of leukemia
...he good news is that ABL1 is counteracted with the drug Glivec, and so this medication can now also provid...ajor cause of certain forms of leukemia. Existing drug now used with T-ALL patientsResearch performed by Jan Cools and his colleagues, under the direction ...DNA sequence controls expression of gene involved in cancer
...d in chemotherapy to induce apoptosis and overcome drug resistance in cancer cells....Penn receives grant for initiative to help understand genes' effects on medications
...in understanding how genetic variability can alter drug response. Despite this promise, the nature of gene...solving the complex biomedical problem of variable drug response. The team will work to generate strategies targeting barriers to interdisciplinary research...US researchers show cottonseed drug is cancer treatment booster
...States has opened up the prospect that gossypol a drug refined from cottonseed oil and previously tried a...xpressed in many cancers, making them resistant to drug and radiation treatment. So, it is not just prostate cancer that our findings are relevant to, but a...Commandeering cellular machinery: recognition mechanism to detect small molecules
...y modified one type of nuclear receptor to bind a drug compound to which it previously did not respond. Based on this success, the researchers hope to demonstrate broader application with other small molecules. The work was sponsored by the Research Corporation, the Seaver Foundation and the National Sc...Research team develops nonhuman primate model of smallpox infection
...he disease no longer occurs naturally, vaccine and drug candidates cannot be tested for their ability to prevent or treat smallpox in humans. Thus, licensing of future medical countermeasures for smallpox will depend upon animal studies. The U.S. Food and Drug Administration (FDA) has established an anim...New biomaterials improve medical devices
...omote regrowth of injured or diseased tissues, and drug and gene delivery systems for treatment of cancer. Twenty-one international research leaders will address the topic of "Challenges and Opportunities for the Biomaterials Scientist". On the first day, the focus will be on research challenges, wit...NIH funds first nationaL SNP genotyping center at Broad Institute
...ssociated with particular diseases or responses to drug therapies. Studies examining genetic variation in...h predisposition to particular diseases or adverse drug reactions. The new center will offer tools to aid in the selection, discovery, and analysis of SNPs ...Protein energy profiles offer clues about amyloids
... the profiles could offer new clues to doctors and drug companies about which proteins are good candidates for drug therapy. Clementi co-authored the latest study with graduate student Silvina Matysiak. Two other gra...September/October 2004 Annals of Family Medicine tip sheet
...sive medications resulted in a significant rise in drug costs in the North Carolina Medicaid program. Anal...1998 and 2000, researchers found that prescription drug coverage costs rose 22.8 percent annually during the study period, from $503 per person per year in ...Is Interleukin-6 the 'holy grail' of exercise mediation?
...verse effects, IL-6 has potential as a therapeutic drug in treating such metabolic disorders as obesity, type 2 diabetes and atherosclerosis. Many roles and sources prompt additional IL-6 research Over the years, "increased levels of IL-6 after exercise is remarkably consistent," Pedersen and a collabo...Bugs in the gut could play key role in understanding human disease and drug toxicity
...s individuals can have very different responses to drug metabolism and toxicity. The microbes can influence things such as the pH levels in the gut and the immune response, all of which can have effects on the effectiveness of drugs." The researchers believe it will be possible to develop a model for test...Report: How 10 top new technologies will help world reach globally-agreed goals by 2015
...th with and without contraceptive effect; Better drug and vaccine delivery methods that avoid the use of... cross contamination; Bioinformatics to identify drug targets and to examine pathogen-host interactions; Nutrition-enriched crops to counter specific de...Study describes basic mechanism in cell growth control involving damaged DNA
...ecycling. They also point to a possible target for drug development: a cellular enzyme family involved in preventing replication of damaged genomic material. "Inevitably, the molecular pathways controlling many cellular processes such as DNA repair must interact with those regulating cell division," said ...Protein protecting brain from toxins also blocks some chemotherapy from reaching tumors
...n called Mrp4 blocks the access of the anti-cancer drug topotecan into the brain by transporting this agen...e veins of specially bred mice that lack Mrp4, the drug accumulated to greater than normal levels in the brain tissue and the fluid that surrounds the brain...Estrogen protects male rats from aortic aneurysms
...ctors involved in AAAs, including how tamoxifen, a drug used to treat breast cancer, affects the process of AAA formation. The research was supported by the National Institutes of Health, the Jobst Vascular Research Fund, the Lifeline Foundation and the University of Michigan. Gorav Ailawadi, M.D., a U-M ...Tips from the Journals of the American Society for Microbiology
... Research from Sweden suggests that adding the drug tucaresol to plasmid DNA influenza vaccines could ...weaker in inducing immune responses. Tucaresol, a drug that stimulates the immune system, is capable of interacting with molecules on the surface of T cell......be, to diagnose the type of cancer, and to release drug molecules in response. Though cancer-detecting computers are still in the very early stages, and can thus far only function in test tubes, Shapiro and his research team envision future biomolecular devices that may be injected directly into the human...