Tag: "drug" at biology news

U of T researcher links schizophrenia, gene mutations

...elusions experienced in schizophrenia, amphetamine drug abuse or Alzheimer's disease. In drug abuse, the reaction is temporary; in schizophrenia, it recurs. "This research brings together two w...

Wnt signalling protein Dishevelled acts in the nucleus, not just in the cytoplasm

...r localisation signal of the protein or by using a drug that disables the nuclear export machinery, impairs function. In mammalian cells, endogenous Dsh responds to Wnt ligands by mobilising to the nucleus. "Our findings are consistent with a scenario in which Wnt signaling may cause nuclear translocation...

New drug may be formidable adversary for hard to treat leukemia

...tailed information about the action of an existing drug was used to design a compound that is effective ag...ases. Despite the resounding success of anticancer drug imatinib (Gleevec) as a treatment of chronic myeloid leukemia (CML), a small but growing number of p...

Studies reveal methods viruses use to sidestep immune system

...arget and control host immune defenses will aid in drug development to combat disease, he said. In the Vi...n. It is transmitted primarily through intravenous drug use, blood transfusions or blood products, as well as through sexual contact and is the leading caus...

Study shows naturally occurring proteins protect against rapid tumor growth

...s, which could help lead to the development of new drug treatments to help keep existing tumors at bay, are reported in the early edition of the Proceedings of the National Academy of Sciences (PNAS) and in the Feb. 22 edition of the publication. Angiogenesis, the process by which new blood vessels are de...

Diabetes' link to obesity broken in mice

...abetes. Based on what they learned, they applied a drug treatment in their new transgenic mice and in a di...and a diabetes-like condition. In both groups, the drug increased insulin sensitivity, which is a primary goal of diabetes treatment. "These results confi...

'Blips' in HIV treatment are not cause for alarm

...t that they could signal either the development of drug resistance by the virus or reduced drug efficacy. Such concerns have led to patient anxiety, costly repeat testing, or unnecessary alteratio...

Cardiologist to testify at FDA hearing: Animal tests implicated in Vioxx tragedy

...more reliable human-based methods such as studying drug metabolism using human liver subcellular fractions." Liver toxicity is the major reason for drug re-labeling and withdrawal, and it often does not show up in dogs and other animals. WHO: Cardiolo...

Merck CEO Raymond Gilmartin to lecture at NJIT

..., Inc. is one of the most respected and successful drug makers in the world. Headquartered in Whitehouse S...anthropy. For nearly 20 years, Merck has donated a drug to treat river blindness in Africa and Latin America. The company responded to the recent tsunami di...

Could schizophrenia arise from a single defect?

... bred to be either resistant or susceptible to the drug apomorphine. A long history of studies has revealed that apomorphine-susceptible rats show many behavioral and biochemical differences from normal rats. What's more, the tendency to develop these differences depends on their exposure to stress in ear...

Spit, and call me in the morning

...dily fluids of choice for physicians, dentists and drug testers, researchers said today at the 2005 Annual... require needles and can be done while a doctor or drug tester watches. As the panelists explained, researchers are making progress in both developing the t...

Researchers identify target for cancer drugs

...a missing puzzle piece, a finding that may present drug makers with a significant new cancer target. "We b...ly studied as the target for the immunosuppressant drug rapamycin (in fact, mTOR is an acronym for "mammalian target of rapamycin"). In July of 2004, Dos Sa...

Brain region learns to anticipate risk, provides early warnings. suggests new study in Science

...vidence that the same neurotransmitter involved in drug addiction and Parkinson's disease, namely dopamine, seems to play a key role in training the ACC to recognize when to send the early warning signal," he added. Known to be an important component of the brain's executive control system, the ACC is bel...

Purdue proves concept of using nano-materials for drug discovery

...uld be used to quickly screen millions of untested drug compounds that exist in large pharmaceutical "libraries." The chips could dramatically increase the number of experiments that are possible with a small amount of protein. "It's been very hard to study these proteins because they are difficult to pro...

Familiar blood pressure drug may prevent osteoporosis

...TON-- (Feb. 20, 2005) -- A form of beta blocker, a drug commonly used to lower blood pressure and ward off...ld have the prevention of osteoporosis with a safe drug and no heart effect. There is a lot of reason to believe it can be done," said Karsenty. He is also ...

Why some lung cancers stop responding to Tarceva and Iressa

...implying that the second mutation was the cause of drug resistance. Further biochemical studies showed that this second EGFR mutation, which was the same in all three tumors, could confer resistance to the EGFR mutants normally sensitive to these drugs. "It is especially interesting that the mutation we f...

UAlbany CNSE enters NanoBio alliance with Albert Einstein College of Medicine

... design and evaluation clinical implementation drug discovery and delivery toxicology detection and cure medical devices and components demonstration and deployment Under the terms of the agreement, CNSE and Albert Einstein will provide their respective faculty and scientists with access to their...

Top experts and scientists at BioFinland 05 Congress

...me Genomic Drug Discovery will approach the entire drug discovery chain from bench to bedside. Identification of targets, validation, and clinical trials are dramatically changing as a consequence of powerful genomics tools being applied in all these areas. The congress speakers come both from the industr...

Urgent measures needed to retain our lead in pharmaceuticals

...r. Ruth March of Astra Zeneca says,"Pharmaceutical drug development is a lengthy and inefficient process w...pment reports that R&D costs for an innovative new drug approved in 2001 were $1.1 billion. However, the Centre's Dr. Christopher Paul-Milne, Tufts Universi...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...sual metabolic processes that may beexploitable as drug targets." The project also identified some l...ets of inhibitors that could form the basis of new drug therapies," says TIGR President Claire M. Fraser, who supervised the Institute's role in the project...

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(Date:10/15/2014)... be awarded the 44th Rosenstiel Award for Distinguished Work ... research exploring the mechanisms of genomic instability and its ... is the second alumnus to win the Rosenstiel Award; ... 2003. , Alt is the Charles A. Janeway Professor ... School and an investigator at the Howard Hughes Medical ...
(Date:10/14/2014)... shows SIRT6—a protein known to inhibit the growth ... skin cancers by turning on an enzyme that increases ... Previously considered protective, SIRT6 is part of a family ... stability and prevent some of the genetic flaws associated ... lead to cancer. This study, in the journal,s October ...
(Date:10/14/2014)... questions is how to produce enough food to feed ... and Agriculture Organization of the United Nations predicts that ... years to feed a growing global population, and plants ... food production. Plants—grains, cereals, fruits, vegetables, and more—feed ... research must tap into our knowledge of how plants ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
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