Tag: "drug" at biology news
U of T researcher links schizophrenia, gene mutations
...elusions experienced in schizophrenia, amphetamine drug
abuse or Alzheimer's disease. In drug
abuse, the reaction is temporary; in schizophrenia, it recurs. "This research brings together two w...
Wnt signalling protein Dishevelled acts in the nucleus, not just in the cytoplasm
...r localisation signal of the protein or by using a drug
that disables the nuclear export machinery, impairs function. In mammalian cells, endogenous Dsh responds to Wnt ligands by mobilising to the nucleus. "Our findings are consistent with a scenario in which Wnt signaling may cause nuclear translocation...
New drug may be formidable adversary for hard to treat leukemia
...tailed information about the action of an existing drug
was used to design a compound that is effective ag...ases. Despite the resounding success of anticancer drug
imatinib (Gleevec) as a treatment of chronic myeloid leukemia (CML), a small but growing number of p...
Studies reveal methods viruses use to sidestep immune system
...arget and control host immune defenses will aid in drug
development to combat disease, he said. In the Vi...n. It is transmitted primarily through intravenous drug
use, blood transfusions or blood products, as well as through sexual contact and is the leading caus...
Study shows naturally occurring proteins protect against rapid tumor growth
...s, which could help lead to the development of new drug
treatments to help keep existing tumors at bay, are reported in the early edition of the Proceedings of the National Academy of Sciences (PNAS) and in the Feb. 22 edition of the publication. Angiogenesis, the process by which new blood vessels are de...
Diabetes' link to obesity broken in mice
...abetes. Based on what they learned, they applied a drug
treatment in their new transgenic mice and in a di...and a diabetes-like condition. In both groups, the drug
increased insulin sensitivity, which is a primary goal of diabetes treatment. "These results confi...
'Blips' in HIV treatment are not cause for alarm
...t that they could signal either the development of drug
resistance by the virus or reduced drug
efficacy. Such concerns have led to patient anxiety, costly repeat testing, or unnecessary alteratio...
Cardiologist to testify at FDA hearing: Animal tests implicated in Vioxx tragedy
...more reliable human-based methods such as studying drug
metabolism using human liver subcellular fractions." Liver toxicity is the major reason for drug
re-labeling and withdrawal, and it often does not show up in dogs and other animals. WHO: Cardiolo...
Merck CEO Raymond Gilmartin to lecture at NJIT
..., Inc. is one of the most respected and successful drug
makers in the world. Headquartered in Whitehouse S...anthropy. For nearly 20 years, Merck has donated a drug
to treat river blindness in Africa and Latin America. The company responded to the recent tsunami di...
Could schizophrenia arise from a single defect?
... bred to be either resistant or susceptible to the drug
apomorphine. A long history of studies has revealed that apomorphine-susceptible rats show many behavioral and biochemical differences from normal rats. What's more, the tendency to develop these differences depends on their exposure to stress in ear...
Spit, and call me in the morning
...dily fluids of choice for physicians, dentists and drug
testers, researchers said today at the 2005 Annual... require needles and can be done while a doctor or drug
tester watches. As the panelists explained, researchers are making progress in both developing the t...
Researchers identify target for cancer drugs
...a missing puzzle piece, a finding that may present drug
makers with a significant new cancer target. "We b...ly studied as the target for the immunosuppressant drug
rapamycin (in fact, mTOR is an acronym for "mammalian target of rapamycin"). In July of 2004, Dos Sa...
Brain region learns to anticipate risk, provides early warnings. suggests new study in Science
...vidence that the same neurotransmitter involved in drug
addiction and Parkinson's disease, namely dopamine, seems to play a key role in training the ACC to recognize when to send the early warning signal," he added. Known to be an important component of the brain's executive control system, the ACC is bel...
Purdue proves concept of using nano-materials for drug discovery
...uld be used to quickly screen millions of untested drug
compounds that exist in large pharmaceutical "libraries." The chips could dramatically increase the number of experiments that are possible with a small amount of protein. "It's been very hard to study these proteins because they are difficult to pro...
Familiar blood pressure drug may prevent osteoporosis
...TON-- (Feb. 20, 2005) -- A form of beta blocker, a drug
commonly used to lower blood pressure and ward off...ld have the prevention of osteoporosis with a safe drug
and no heart effect. There is a lot of reason to believe it can be done," said Karsenty. He is also ...
Why some lung cancers stop responding to Tarceva and Iressa
...implying that the second mutation was the cause of drug
resistance. Further biochemical studies showed that this second EGFR mutation, which was the same in all three tumors, could confer resistance to the EGFR mutants normally sensitive to these drugs. "It is especially interesting that the mutation we f...
UAlbany CNSE enters NanoBio alliance with Albert Einstein College of Medicine
... design and evaluation clinical implementation drug
discovery and delivery toxicology detection and cure medical devices and components demonstration and deployment Under the terms of the agreement, CNSE and Albert Einstein will provide their respective faculty and scientists with access to their...
Top experts and scientists at BioFinland 05 Congress
...me Genomic Drug Discovery will approach the entire drug
discovery chain from bench to bedside. Identification of targets, validation, and clinical trials are dramatically changing as a consequence of powerful genomics tools being applied in all these areas. The congress speakers come both from the industr...
Urgent measures needed to retain our lead in pharmaceuticals
...r. Ruth March of Astra Zeneca says,"Pharmaceutical drug
development is a lengthy and inefficient process w...pment reports that R&D costs for an innovative new drug
approved in 2001 were $1.1 billion. However, the Centre's Dr. Christopher Paul-Milne, Tufts Universi...
Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
...sual metabolic processes that may beexploitable as drug
targets." The project also identified some l...ets of inhibitors that could form the basis of new drug
therapies," says TIGR President Claire M. Fraser, who supervised the Institute's role in the project...
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