Tag: "duplex" at biology news

DNA constraints control structure of attached macromolecules

...ule, RNA." In previous DNA nanotechnology efforts, duplex DNA has been used as a static lattice to construct geometrical objects in three dimensions. Instead of manipulating DNA alone into such shapes, the researchers are using DNA to control the folding and resulting structure of RNA. Eventually, they envi...

Clearing jams in copy machinery

...ert the now-single-stranded templates into two new duplex DNA molecules. The new research shows that two different DNA polymerases, the high fidelity Pol III replicase and the low fidelity Pol IV, coordinate their action to cross obstacles encountered in the replication process. They attach themselves at th...

Evidence of rapid evolution is found at the tips of chromosomes

...d that TRF2, a shelterin protein that binds to the duplex part of the telomere, is crucial for telomere protection. Without TRF2, telomeres activate a DNA damage signal and are repaired by the same pathways that act on DNA breaks. TRF2 brings a second shelterin protein, POT1, to the telomeres. Because POT1 ...

Lehigh scientist receives NHGRI grant to streamline, expand use of genome sequencing

...or example, about a stretching transition in a DNA duplex that no one could have foreseen." Vezenov says his group will try to answer a scientific question of the ultimate resolution that one can achieve when measuring forces in biomolecules: Can we detect a difference of a single base? "If we can," he sa...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

...Stoynov. The mechanism of how DNA/DNA and mRNA/DNA duplex stability influences mRNA level remains unclear. The authors propose two models, but further work is needed to understand how thermodynamic stability modulates mRNA level....

Triplex assay used to assay duplex genomic DNA

Direct detection of base sequence in duplex nucleic acid has long been an unfulfilled objectiv...pathogens in samples also containing human genomic duplex DNA and to the assay of SNPs present in human genomic samples. The assays are carried out homogeneou...

Hepatitis C helicase unwinds DNA in a spring-loaded, 3-step process

...ing double-stranded host DNA during infection. The duplex created for the experiment included both single- and double-stranded DNA; fluorescent labels were located in the double-stranded region.) By tracking the gradually increasing distance between the two marked nucleotides as the strands separated in a...

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(Date:7/28/2014)... of Medicine have pinpointed a mechanism in part of the ... blood, linking it to both type 1 and type 2 ... of Proceedings of the National Academies of Sciences . ... located in a part of the hypothalamus known as the ... that control glucose levels in the blood," said lead author ...
(Date:7/28/2014)... the top 10 U.S. cities that have seen an ... as frequent road closures, overwhelmed storm drains and compromised ... NOAA technical report. , This nuisance flooding, caused by ... coasts, between 300 and 925 percent since the 1960s. ... Frequency Changes around the United States, also finds Annapolis ...
(Date:7/28/2014)... has identified areas of the Earth that are high ... , Europe is particularly vulnerable, as it has the ... cent, of any continent in ,refugia, areas of ... conditions remain relatively constant during times of great environmental ... mostly in Scandinavia and Scotland. , The biggest ...
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