Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...croenvironment to an environment-independent state during progression of MM. Regardless of the specific method of activation, the NF-κB pathway plays a central role in MM pathogenesis and is an excellent target for development of new therapeutics.......otrophin receptor p75NTR, which normally functions during development to induce neurite outgrowth and promote neuronal cell death, as an important regulator of glioma invasion. The researchers present the first evidence that this neurotrophin receptor can also be a potent mediator of glioma invasion, and th...Doernbecher Children's Hospital scientist earns coveted Javits award
...alls below normal or when maternalinfection occurs during pregnancy. Critically ill premature babies areespe...ry from either cause. White matter injury occurs during brain development when nerve fibersin the white matter are actively being wrapped in myelin, the ins...Risk of common vaginal infection linked to preterm birth appears higher for blacks
...paternal race is an independent risk factor for BV during pregnancy, and that this is at least as important a risk factor as maternal race, continued Dr. Simhan. Studies on the contribution of BV to adverse pregnancy outcomes should consider paternal race as an important factor. A recent study from the U....ESF EURYI award winner aims to stop cancer cells reading their own DNA
...lar motors involved in copying genetic information during cell division is being pursued by young Dutch rese...nterfering with the molecular motors that copy DNA during cell division. This will cut off the genetic information flow that tumours need to grow, and could c...1 of deep ocean's most turbulent areas has big impact on climate
...versity. The field study took place in August 2006 during a three-week expedition aboard a French research vessel to a location close to the Azores, volcanic islands 2,000 miles east of the U.S. and west of Europe that comprise an above-sea portion of the mostly submerged Mid-Atlantic Ridge. To measure th...A unique arrangement for egg cell division
...d on from mother to child is decided very early on during the maturation of the egg cell in the ovary. In a ...se the second half is brought in by the sperm cell during fertilisation. The molecular apparatus that makes sure that the egg ends up with the correct number ......critically important fossil from an ape that lived during the late Miocene of Spain. While the authors ponder that the fossil may be from a direct ancestor of living great apes (especially the orangutan), Dr. C. Owen Lovejoy, Kent State University Professor of Anthropology, suggests another possibility in h...Acute sleep deprivation leads to changes in nighttime urine production for men and women
...terrupted sleep. The regulation of urine excretion during nighttime hours is influenced by many factors, inc...and fluid intake. Participants were sleep deprived during one of the two sessions in a randomized sequence. Their blood pressure and heart rate were recorded ...Study finds gender differences in renal and other genes contributing to blood pressure
...blood pressure measured in more than 53,000 people during routine health exams in a major health maintenance program in Southern California. This approach provides over 90 percent statistical power to detect genes contributing as little as three percent to blood pressure variation. The research team also ...Cardio exercise benefits in male vs. female hearts
...sing a running wheel) of both male and female mice during the course of 5 weeks. They also held a control gr...cardiograph to better evaluate any cardiac changes during the course of the study. They also isolated and analyzed the RNA of each mouse to look at any change...Sugar and spice and everything nice: Health differences in newborn girls and boys
...elopment of tissue acidity (acidosis) in the heart during a lack of blood flow (ischemia) might play a role....newborn female hearts can develop greater acidosis during ischemia, which may place them at greater metabolic risk According to the research team, the resu...Research aims to identify markers for menopausal women at risk for deadly blood clot
...t the disorder is rare, it increases exponentially during menopause and can be deadly. The hormone trials conducted thus far, focusing on proteins in blood coagulation, have not yet led to a risk profile, thereby precluding identification of women at risk. Now, a team of Mayo Clinic researchers, led by Virg...What we can learn from the biggest extinction in the history of Earth
...eat Bank of Guizhou formed in shallow ocean waters during the late Permian and early Triassic periods. As th... index to try to understand how climate did change during the end-Permian period. Two other students will examine coral reef structures. The Great Bank of G...New technology reveals seal behavior
...the world to obtain oceanographic data, especially during the wintertime. The seals acted as samplers to collect data from deep seas that we couldnt ordinarily access due to their remoteness and harsh environments. Understanding how these animals respond to their environment is fundamental in predicting how...Ecologists work to link kids with nature
...ional Parks, Forests and Public Lands Subcommittee during a hearing held this past spring. A line-up of inv...rida) and Bob Pohlad (Ferrum College) will be held during the joint meeting of ESA and the Society for Ecological Restoration. Richard Louv, whose 2005 bo...Secret life of elephant seals not secret anymore!
...hanges in the rate at which seals drift up or down during passive drift dives, the scientists could determin...fic seals have to travel more than 1000 km further during their winter migration than Atlantic seals. The extra energy expended would mean less energy for bre...Other highlights in the Aug. 7 JNCI
...d several sites below the diaphragm (areas exposed during radiation treatment for testicular cancer) had poorer survival than patients whose first cancers were in the same area. Treatment regimens for testicular cancer used since 1980 have not adversely affected survival from subsequently diagnosed cancer...Argonne wins three R&D 100 awards for innovative technologies
...s top 100 scientific and technological innovations during 2006, as judged by R&D magazine. Argonne scienti...reat patients without exposing others to infection during the SARS epidemic in 2003. Developers are Argonne Senior Software Developers Ivan R. Judson and Th...In limiting life span, study finds booming bacteria innocent
...bited dramatic increases in many types of bacteria during aging, both inside the body and on the surface. It was gradual across their life span, Tower said. It went from virtually undetectable to a million or more per fly. Using a scanning electron microscope to examine the insects outer surfaces, the res...