An embryonic stem cell model for Parkinson's disease
...roteins and DNA. In a second paper, they link DJ-1 dysfunction to the aggregation of alpha-synuclein, a hallmark of Parkinson's neuropathology. Oxidative stress has long been associated with neuronal cell death and neurodegenerative diseases like Parkinson's. Proving a causal relationship between oxidative st...Muscle-building hand-grips aid systolic blood pressure, carotid AD, endothelial function
...ction Hypertension is associated with endothelial dysfunction and development of cardiovascular disease, noted Cheri L.M. McGowan, who led the other McMaster study. Her group studied endothelial function after IGH to see if it played a role in the reduction of blood pressure in people taking anti-hypertensive m...Other highlights in the October 20 JNCI
...asma levels of methotrexate in patients with renal dysfunction after systemic administration of high doses of methotrexate. To see if intrathecal carboxypeptidase G 2 could be used to treat accidental overdoses of intrathecal methotrexate in humans, Brigitte C. Widemann, M.D., of the National Cancer Institute, ...Gene for Joubert syndrom with excessive brain folds discovered by UCSD researchers and Harvard team
...can understand how the AHI1 gene works and how its dysfunction leads to disordered brain development, it can tell us something about the biology underlying a common disorder like autism." Also important are the implications for genetic testing, Gleeson added. "We receive frequent calls from par...Gene therapy approach reverses diabetic neuropathy in animal model, Pitt study finds
...e to suggest it is associated with a deficiency or dysfunction of certain neurotrophic factors, which are proteins essential for the survival and proper function of neurons. Therefore, the Pitt researchers sought to develop a therapy that would shuttle the genes responsible for their production directly into aff...Yerkes researchers to present array of new data at Society for Neuroscience Meeting
...inding that could lead researchers to design motor dysfunction therapies based on gender. (5 p.m. 8 p.m.) (Note: This abstract is featured in the Annual Meeting Press Book.) October 27, 2004 Each study is embargoed until the date and time of presentation. Poster Presentations Dr. Preuss and Mario Ca...IRCM scientist demonstrates basic active mechanism of immune-system cells
... mutations occur in humans, causing a fatal immune dysfunction known as "X-linked lymphoproliferation" (XLP). Dr. Veillette's discovery paves the way for the development of SLAM, SAP or FynT inhibitors, which could block excessive immune responses observed in patients with autoimmune diseases. ...Down Syndrome protein reduces tumor growth
... and inflammation are caused by the activation and dysfunction of the endothelium. This layer of cells lines the ...the University of Tokyo. "Indeed, endothelial cell dysfunction underlies many disease states in humans, including--but certainly not limited to--stroke, coronary a...JCI table of contents, December 1 2004
...es targeted to the genetic defects causing chronic dysfunction of the heart. Evidence suggests that abnormal tran... of laminin-alpha2 function leads to neuromuscular dysfunction and often early death. Researchers have previously proposed that programmed cell suicide, known as a...NIH provides $32.8 million to enhance biomedical informatics research network
...to determine the role of frontal and temporal lobe dysfunction in schizophrenia, and to assess the impact of trea...l differences correlate to symptoms such as memory dysfunction or depression and whether specific structural differences distinguish diagnostic categories. The M...Genetic defect confers risk of major depression, resistance to SSRI drug therapy
...ngs provide a novel molecular mechanism underlying dysfunction in serotonin neurotransmission in some patients with depression." The genetic defect is the first genetic variant of functional consequence in the production of serotonin identified in any psychiatric disorder, the researchers said. Patients with d...DFG establishes three new clinical research units
... a lack of glucose (neuroglycopenia) can result in dysfunction and can even be fatal. Hepatitis C infection is still a serious health problem. More than 170 million people worldwide, and 500,000 in Germany alone, are infected with this virus. The success rate of the therapeutic methods available to date is only...New route to Parkinson's found in cells' 'garbage disposal' system
...rkin's ability to protect cells against proteasome dysfunction and cell death. In experiments with rats, the researchers found that BAG5 enhanced the degeneration of dopaminergic neurons and that inhibiting BAG5 increased neuronal survival. "Based on our findings, we propose a novel mechanism for neurodegenerati...Growth of common skin cancer blocked in gene-switch mice
...ay plays a key role in normal development, and its dysfunction has been implicated in a number of different human diseases and neoplasms, including BCCs in skin and cancers arising in brain, lung, prostate, pancreas and other gastrointestinal organs. Dr. Dlugosz and colleagues focused on the function of uncontr...Born to run? Capacity for aerobic exercise linked to risk of heart disease
.... "In addition, we found evidence of mitochondrial dysfunction in the low-capacity rats. Compared to high-capacity rats, the low-capacity rats had lower levels of oxidative enzymes and proteins used by mitochondria to generate energy in skeletal muscle." "Our goal in selecting and breeding these rats over many ...Study discovers serious deficiencies in 'apparently normal' heart valves
...plain the mixed success of surgery to repair valve dysfunction in these patients. The valves of patients with congestive heart failure often fail to close properly, allowing blood to leak back through the valve when the heart contracts. The problem, known as mitral regurgitation, has typically been ascribed to e...Report assesses health implications of perchlorate ingestion
...ple with low iodide intake or pre-existing thyroid dysfunction might be lower. There have been studies on the health effects of human populations exposed to perchlorate, but they were studies in which data were available for geographic areas, not for individuals. Relationships observed at the geographic level ...Scientists reveal cells' 'energy factories' linked to cancer
...isease in the future." "Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-a prolyl hydroxylase", is published in Cancer Cell 2005 7: 77-85....Duke researchers uncover genetic link to kidney damage after heart surgery
... University Medical Center have found. While renal dysfunction after heart surgery is a common occurrence, until ...to four-fold greater likelihood of suffering renal dysfunction after heart surgery. This is important, the researchers said, since one out of every 12 patients who...Childhood deficits in the cerebellum may be linked to adult alcoholism
...tional behavior that is associated with cerebellar dysfunction may give an individual characteristics that could make them vulnerable to addiction problems. "Someone having problems coordinating these functions," said Manzardo, "might be inclined to act on their emotional impulses without thinking about the con...