New therapy for specific form of leukemia
...es at the root of T-ALL − which has a direct effect on the treatment of T-ALL patients. Indeed, a drug exists − called Glivec − that suppresses the action of ABL1. Glivec has already been successfully administered to patients with other forms of leukemia in which ABL1 plays a role. The new...Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
... months of treatment. AMG 162 also had a positive effect on BMD at the hip, distal 1/3 radius, and total body. In this trial, AMG 162 was well tolerated. The most common adverse event in any of the treatment groups was dyspepsia (4 percent, 5 percent and 20 percent in the placebo, AMG 162 and the open ...Endangered frogs coexist with fungus once thought fatal
...n disease now coexists with the frogs, with little effect on their populations. While these findings do not exonerate the fungus as the agent of mass declines, they can rule out the possibility that the fungus caused the decline, then vanished from the area, allowing frog populations to recover. Although...Stanford cooling tool may improve performance of athletes, soldiers
...ease heat flow back to the core," Grahn says. "The effect was remarkable--we were able to rewarm people in 10 minutes, down from the typical recovery time of two hours." Grahn and Heller went on to develop new technology for treatment of chronic medical conditions where heat sensitivity is a problem, s...Below the surface: New clues to plant signaling from the roots
... to understand the ways in which roots are able to effect this developmental control from afar. Several characterized plant hormones, such as cytokinin and abscisic acid, are thought to be transmitted from root to shoots, yet these hormones have no clearly established role in coordinating shoot growth. ...Running not swimming or biking is best kind of loading exercise for childrens bone growth
...ing through exercise builds bone strength and this effect is most pronounced during skeletal growth and deve...eight, he adds. Turner says that the strengthening effect of exercise is very efficient because the cellular mechanosensors within bone direct osteogenesis (n...September/October 2004 Annals of Family Medicine tip sheet
...x of Well Being, an instrument used to measure the effect of spirituality on well-being, is a valid and reliable measure of well-being in primary care outpatients. They suggest the instrument may be useful in studies that investigate health-related quality-of-life and chronic illness, aging and end-of-life ...Does a time delay between prostate cancer diagnosis and start of radiation treatment matter?
...nt. "The purpose of this study was to evaluate the effect of treatment delay on the outcome of these men who choose external-beam radiation," Andrews said. The study looked at data for 1,498 patients treated with external-beam radiation between 1981 and 2001. The median follow-up was 57 months, with a mini...... more information about individual genes and their effect on important traits in cattle. The first draft was based on DNA taken from a Hereford, a breed of cattle used in beef production and was produced by sequencing the genome 3.3 times. The final target, which is expected to sequence the genome six times...Researchers find chemosignal that encourages women's sexual desire
...women exposed to the breastfeeding substance, "The effect became striking during the last half of the menstrual cycle after ovulation when sexual motivation normally declines," McClintock said. Further study is needed to determine if the chemosignals the team discovered are pheromones. In order t...Muscle-building hand-grips aid systolic blood pressure, carotid AD, endothelial function
...s at 30% of maximal voluntary contraction. IHG's effect on carotid distensibility Adrienne Visocchi led a...tested isometric leg press exercise, but it had no effect on any of the parameters being studied. IHG's effect on endothelial function Hypertension is asso...After flu exposure, mild exercise protects mature mice from dying
...ed with mice that didn't exercise. This protective effect was more evident in mice greater than 16 weeks of ...uestion they addressed in their study, "Protective effect of exercise on mortality due to influenza in mice," was "can exercise protect against morbidity and ...Obese women with early-stage breast cancer more likely to die than women of normal weight
...that enhance weight control may have a substantial effect on breast cancer outcome," Anderson said....MIT: Recycling of scrapped electronics studied
...is is just a baseline and does not incorporate the effect of device or component reuse. They also note that other criteria could be used to assess the performance of recyclers. Examples include toxicity, emissions, energy use, and operating costs. In the long run, a variety of independent metrics could lead...Sedentary overweight people get insulin boost from short term exercise; CVD risks trend down
...aun added: "The new finding is that the beneficial effect of exercise (in the short-term) appears to be medi... energy intake and expenditure. So, the 'exercise' effect can be opposed by adding back the energy expended during exercise. The implication is that the 'exer...Estrogen protects male rats from aortic aneurysms
...s were transplanted into male rats, the protective effect disappeared. Every male rat that received a female aorta developed an aneurysm. "The fact that all the male and female aortas developed aneurysms when transplanted into male rats, compared to only 17 percent of the female aortas in female rats, sugge...Study in Royal Society journals presents evidence for inherited factors in homosexuality
...ping large-sized breeders. We discuss whether this effect is due to helper growth 'restraint' or whether breeders actively interfere with the growth rate of their helpers.Contact: Dr Dik Heg, Behavioural Ecology, Zoological Institute, University of Bern, Wohlenstrasse 50a, HINTERKAPPELEN, CH-3032, Switzerla...Gladstone researchers resolve key Huntington's disease mystery in Nature cover story
...lationship, is one event possibly the cause or the effect of the other? If it is a cause, is it a minor determinant or a major one? These are questions that recur in all aspects of cell biology. As Professor Harry T. Orr of the University of Minnesota explains in a companion Nature commentary, "In the lon...Coke versus Pepsi: It's all in the head
...f brand knowledge for Pepsi, they found a dramatic effect of the Coke label on behavioral preference. The brand knowledge of Coke both influenced their preference and activated brain areas including the "dorsolateral prefrontal cortex" and the hippocampus. Both of these areas are implicated in modifying beh...... however, the circadian clock has its most overt effect on the fly's level of activity. In both flies and humans, the clocks are circuits of neurons that naturally oscillate with a circadian periodicity. Inside these cells, the molecular components of the clock are "rewound" daily by the effects of light ...