Stem cell therapy for ailing hearts
...amining the mechanisms that mediate the functional effects of stem cell transplantation." The USF researchers compared HUBC-treated rats to both untreated rats (those receiving only a sugar water placebo) and control rats with normal hearts. The HUCB stem cells were injected directly into the heart muscle of...Genetic polymorphisms, antidepressant use may be associated with altered tamoxifen activity
...ifen, are known to inhibit CYP2D6. To examine the effects of SSRI use and variations of the CYP2D6 allele on plasma concentrations of tamoxifen and its metabolites, David A. Flockhart, M.D., Ph.D., of the Indiana University School of Medicine in Indianapolis, and colleagues studied 80 women with newly diagn......ber and fluid ingestion nor threatened by the side effects of laxatives. Also, unnecessary colonic resections may be avoided." According to the American College of Gastroenterology, constipation is one of the most frequent gastrointestinal complaints in the US and Western countries. There are at least 2.5 m...US Oncology, Inc. plays role in newly approved ABRAXANE for metastatic breast cancer
...our trials with weekly ABRAXANE, we saw fewer side effects than observed with solvent-based paclitaxel, and, even more encouraging, we saw a significant response to ABRAXANE in some women whose cancer had progressed through treatment with taxanes. Women taking ABRAXANE also spent less time in the clinic rec...Lynn Sage Comprehensive Breast Center plays role in newly approved breast cancer drug, ABRAXANE
...ent with ABRAXANE and experienced less severe side effects that made treatment more tolerable." ABRAXANE is engineered using a proprietary process (protein bound nanoparticle technology) to create tiny particles (nanoparticles 100th the size of a red blood cell) in which the active chemotherapeutic drug, pa...US researchers uncover the science behind the breast cancer protective effect of olive oil
... the Mediterranean diet has significant protective effects against cancer, heart disease and ageing." The strongest evidence that monounsaturated fatty acids such as oleic acid may influence breast cancer risk comes from studies of southern European populations, but animal research to date has thrown up i...Cleft palate research receives 200,000 award
...ategy will allow her to investigate the downstream effects of this mutation on other proteins involved in palatal development. In the short term, the results of this research will help to dissect the role of p63 in normal and abnormal development of the palate. In the longer term, this information may help i...Healthy cleavage: How statins protect against Alzheimer disease
... cleavage of APP. When they then blocked ROCK, the effects were similar to those of the statins: an increase in healthy cleavage. On the other hand, when they added a super-active version of ROCK, they saw much less healthy cleavage, and adding statins didn't improve the situation. These findings sugges...Anti-seizure drugs slow aging in worms
...parent that the drugs did not mimic the anti-aging effects of caloric restriction, because the worms had abundant food and looked well-fed. The researchers also demonstrated that anticonvulsants did not extend life by protecting the worms from pathogenic bacteria in their environment. Ethosuximide and trimet...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...ment. While scientists have previously studied the effects of these pollutants individually, this is the firs...th different combinations of BCE and studied their effects on nerve cell growth. "On a cellular level, clam neurons are extremely useful in studying basic mech...EB and IUPS - Where cures of tomorrow can be seen in the science of today
...tibility to estrogen carcinogenesis; and long term effects on adolescents' developing brains of nicotine, stimulants and other drugs. Other sessions focus on the effect of social structure and influences on drug actions and discuss how pharmacologists and other scientists can talk about drugs in high school...COX-2 levels are elevated in smokers
...enberg investigated the mechanism of tobacco smoke effects on oral mucosa with team of scientists including Dimitrios Moraitis, M.D., Jay O. Boyle, M.D., and Erik G. Cohen, M.D., Memorial Sloan-Kettering Cancer Center, New York, N.Y; Baoheng Du, M.D., Mariana S. De Lorenzo, Ph.D., Babette B. Weksler, M.D., K...Research sheds light on how cancer cells become resistant to treatment
...ies, protecting otherwise sensitive cells from the effects of anti-cancer treatment in vivo and in vitro. According to the authors, the research is the first to demonstrate that a protein transferred between cells retains its function long enough to allow the recipient cells to survive potentially toxic drug...Combination therapy boosts effectiveness of telomere-directed cancer cell death
...se 1 activity and telomere shortening decrease the effects of telomerase inhibitors. Importantly, tankyrase inhibition enhanced telomere shortening upon treatment with a telomerase inhibitor and accelerated cancer cell death. "This study provides insight into strategies for telomere-based molecular cancer th...Blood test shows promise as monitor for antiangiogenic cancer therapy
...in clinical trials, no reliable way to monitor the effects of many, if not most, of these therapeutic agents on the inhibition of the complicated process of angiogenesis exists. Dr. Robert S. Kerbel from Women's College Health Sciences Centre in Toronto and colleagues, including Dr. Francesco Bertolini of th...Fat hormone acts on brain circuit to curb obesity, diabetes
...ificant, though more modest, control over leptin's effects on body weight. The findings in mice provide insig...nted for approximately 22 percent of the hormone's effects on body weight, the group reports, suggesting that other brain regions are also important to this ho...Study in Royal Society journal on managing GM crops for environmental benefit
...sessing sperm from several males can have negative effects on females. We artificially inseminated females with sperm only from either a single or several males to avoid any direct contact between the sexes. Females receiving sperm from several males were more likely to die during hibernation, survived short...First birth using PGD to save baby from rhesus blood disease
...here their second child had developed serious side effects as a result of alloimmunization." Dr Seeho said that PGD has mainly been used since its introduction in 1990 to detect single gene diseases such as cystic fibrosis, or to screen for chromosomal disorders. But, in this case the research team used the ......been disappointing. In human studies, neurological effects of TMS have been transient, rarely lasting longer ...otor cortex that controls muscle response, because effects on the motor cortex can be objectively measured by recording the amount of electrical muscle respons...