New findings may redirect strategies for treatment of prostate cancer
...t modulation of androgen receptor function through effects on DNA binding and stability" ...JCI table of contents, November 15 2004
...ental or genetic factors. The authors examined the effects of insulin on muscle PGC levels in young and old, identical and fraternal, non-diabetic twins. The authors demonstrate that the expression levels of PGC-1alpha and PGC-1beta in muscle are increased by insulin stimulation and decreas...Aging affects susceptibility to type 2 diabetes
...ental or genetic factors. The authors examined the effects of insulin on muscle PGC levels in young and old, identical and fraternal, non-diabetic twins. The authors demonstrate that the expression levels of PGC-1alpha and PGC-1beta in muscle are increased by insulin stimulation and decreased by aging. Th...Army-funded effort examines androgen's role in bone loss
...sks for prostate cancer progression and other side effects that can result from androgen replacement. The Army grant, which began in November, comes on the heels of a study Wiren published in July in the journal Endocrinology. In it, she describes her research team's development of a transgenic mous...Muscle loss from space travel, prolonged inactivity linked to two genes
...ild-type") mice, Kandarian was able to isolate the effects either gene had on triggering atrophy in each of two weight-bearing muscles in the mouse hind limb: the soleus, a so-called slow-fast muscle, and the plantaris, a fast muscle. The differing muscle fiber make-up allowed Kandarian to assess what chang...Ground-level ozone linked to increased mortality
... of Public Health, which routinely assesses health effects of air pollution on a national scale. To determine the association between ozone and mortality, the researchers looked at the total number of non-injury-related deaths and cardiovascular and respiratory mortality in the 95 largest U.S. communities fr...Study links ozone, mortality in urban areas
... this study provides strong evidence of short-term effects of ozone on mortality," said Francesca Dominici, senior author and associate professor of biostatistics at Johns Hopkins. Bell said that a reduction of 10 parts per billion, or roughly 35 percent of the average ground-level ozone on any particular d...Other highlights in the November 17 JNCI
...hanisms for this association, including selenium's effects on gene promoter methylation and polyunsaturated fatty acid metabolism. Contacts: Article: Donna Breckenridge, Arizona Cancer Center, 520-626-2277, dbreckenridge@azcc.arizona.edu Editorial: Laura Sussman, M. D. Anderson Cancer Center, 713-745-2...Researchers discover new way to boost grain crops' drought tolerance
...In addition, the plants were more resistant to the effects of adverse environmental conditions. Surprisingly, by reducing the level of ethylene, all the leaves of the altered plants contained higher levels of chlorophyll and leaf protein, and functioned better than control leaves. "Thus, they are better abl...Plankton cool the southern hemisphere
...e a far greater effect on the Earth's climate. The effects of the DMS production by plankton are particularly noticeable at a regional level....Tips from the Journals of the American Society for Microbiology
...otics are needed to achieve the same antimicrobial effects onbiofilm organisms as on planktonic microorganisms," say the researchers. In the study researchers examined whether or not electric currents(direct currents and block currents) would be effective at causing aStaphylococcus epidermidis biofilm to det...Antipsychotic drugs stop fatal viral infection in brain cells
...e many other drugs with none of the potential side effects of antipsychotic drugs that will also block infect...ceptors and is not likely to have many of the side effects associated with drugs like clozapine and chlorpromazine," Roth said. Atwood is establishing collabor...Cardiovascular and neurological benefits of high antioxidant foods and beverages
...eph is one of the leading researchers studying the effects of high-antioxidant fruits, vegetables and beverages on neurological function and aging. His work has been published in numerous scientific journals, and is the author of "The Color Code: A Revolutionary Eating Plan for Optimum Health." John D. Fol...Low-carb diet during pregnancy improved triglycerides, fat metabolism in offspring
... diet during gestation has long-lasting beneficial effects on lipid metabolism in the offspring was investigated using a mouse model. Female mice were fed either a standard (CHO-rich) chow diet or a low carbohydrate HFP diet, prior to and during gestation and lactation. All offspring were weaned onto the sam...Studies suggest promising new directions for gallstone treatment
...all the sequelae of CGD, we decided to explore the effects of enhancing FXR activity in a strain of mouse tha...y GlaxoSmithKline. Mangelsdorf said the compound's effects were dramatic. "Their cholesterol saturation, bile lipids, and bile hydrophobicity were normal. And ...... researchers discovered that Lmo's cocaine-related effects were localized to the circadian pacemaker neurons. The researchers then asked if the Lmo mutations also affect the normal rhythms in circadian behavior. Subsequently, NYU's Justin Blau, an assistant professor of biology, found that many Lmo mu...This is your fly's brain on drugs
... is enriched in the brain, and its cocaine-related effects appear to localize in the ventral lateral neurons (LNvs), which provide the fly with an internal clock, driving circadian activities even in the absence of light. However, it appears that these neurons modulate cocaine sensitivity independently of t...Livestock grazing study finds moderate grazing beneficial to Great Basin plant communities
... new ammunition in the dispute over the long terms effects of livestock grazing. An article released this wee...the longest, study of its kind." To determine what effects the grazing of large ungulates--cattle and sheep, for example--have had on such things as the amount...Studies in Royal Society journals include stress in birds and depletion of medieval fish stocks
...hronic stress in song sparrows. These inseparable effects on the individual's physiology provide a link between the well-known effects of food and predators on behaviour and inseparable food and predator effects on demography we previo...Pain reliever may help treat life-threatening childhood disease
...evels aren't high enough to stop SMA's deleterious effects on spinal motor neurons. Laboratory experiments us... The researchers also tested indoprofen's effects on mice pregnant with SMA offspring. "What is still unclear is at what point motor neuro...