Common household fragrances may be harming aquatic wildlife, study finds
...nces. "It consists of a special protein, called an efflux transporter, that's embedded in the cell membrane ...l red fluorescent dye. Under normal conditions, an efflux transporter will recognize the dye as a foreign substance and remove it. But if something interfere...How HDL keeps the heart healthy
... off a cellular signal that depends on cholesterol efflux and two intact domains of SR-BI the transmembrane domain and its cytoplasmic tail. These regions of SR-BI may serve as "cholesterol sensors" which set into motion cellular events to activate eNOS. This may be the mechanism responsible for the abil......leave the cell. Further research revealed that the efflux of organics only starts one or two minutes later. This efflux only takes place if there is a large difference between the intracellular and extracellular salt con...New study reveals structure of E. coli multidrug transporter protein
...nd binds cyanide m-chlorophenyl hydrazone, a known efflux pump inhibitor, before it reaches the cell cytoplasm. This binding is likely facilitated by hydrophobic interactions within the internal cavity of EmrD. The researchers speculate that cyanide m-chlorophenyl hydrazone is either expelled from the bacte...Resistance to chemotherapy in lung cancer, optimizing flu vaccination strategies
...l cells and also made more detoxification enzymes, efflux proteins, and antioxidants than normal cells. And Biswal and colleagues showed that lung cancer cells with KEAP1 mutations were more resistant to chemotherapy drugs than normal lung cells. These results indicate that biallelic inactivation of KEAP1...A chilling solution: Measuring below-ground carbon without destroying trees
...nheit through the tubing, measuring carbon dioxide efflux from the soil to determine if carbon movement was reduced The researchers hypothesized that carbon movement in trees would differ at varying points in the year; this was confirmed in their study. "There was no response to either chilling or physic...Structural mechanism of the E. coli drug efflux pump AcrB
...o probe the molecular mechanisms of the major drug efflux pump in E. coli AcrB. Bacterial resistance to antibiotics is a major challenge for the current treatment of infectious diseases. One way bacteria can escape destruction is by pumping out administered drugs through specific transporter proteins that...New approach could lower antibiotic requirements by 50 times
...y multi-resistant to antibiotics because they have efflux pump mechanisms that enable them to throw out anti...A pore in the cell wall would obviously cancel the efflux effect,' Hagens explains. Pseudomonas bacteria cause pneumonia and are a common cause of hospital-a...Bacterial response to oxidation studied as toxin barometer
...e stress is called the glutathione-gated potassium efflux (GGKE) response. Typical bacterial you find anywhe...xins using a bacterial glutathione-gated potassium efflux stress response biosensor (GEOC 51) at 3:25 p.m., Monday, March 26, in McCormick Place North room N4...Antibiotic stress, genetic response and altered permeability of E. coli
... for as many as 9 transporter proteins of distinct efflux pumps which extrude unrelated antibiotics prior to...ability of the bacterium due to over-expression of efflux pumps and down-regulation of porins. ...Story ideas from the Journal of Lipid Research
...BCA1 variants, HDL levels and cellular cholesterol efflux in subjects with Familial low-HDL ," by Aino Soro-Paavonen1, Jussi Naukkarinen, Miriam Lee-Rueckert, Hiroshi Watanabe, Elina Rantala, Sanni Soderlund, Anne Hiukka, Petri T Kovanen, Matti Jauhiainen, Leena Peltonen, and Marja-Riitta Taskinen MEDIA C...... and ABCG1, have been shown to promote cholesterol efflux and protect against atherosclerosis in mice, but their roles in mediating reverse cholesterol transport from macrophages remains unclear. In a study appearing online on July 26 in advance of publication in the August print issue of the Journal of Cli...