New antibody for EGFR causes lung cancer regression
Mutant forms of the protein EGFR are important for the development of lung cancer in a substantial proportion of individuals with this disease. However, not all individuals express the same mutant EGFR, for example, some have a mutation that affects the intracellular part of EGFR and some have a mutation that affects the extracellular part of EGFR (known as the EGFRvIII mutant). The potential of...Lung cancer-derived EGFR mutants exhibit intrinsic differences in inhibitor sensitivity
... Many human malignancies exhibit mutated forms...Novel EGFR ectodomain mutations in glioblastoma
The Epidermal Growth Factor Receptor (EGFR), a so-called kinase protein, is often abnormally active in cancer. A new class of anticancer drugs inhibiting the activated EGFR kinase have shown to be effective against such cancers, especially lung cancer. In a new study in PLoS Medicine, researchers have catalogued and characterized the mutations in the EGFR gene that occur in glioblastoma, a deadl...Tom Siegfried wins AGU's Cowen Award for Sustained Achievement in Science Journalism
Tom Siegfried, freelance writer and former science editor of the Dallas Morning News, has been named winner of the Robert C. Cowen Award for Sustained Achievement in Science Journalism. The award is presented by the American Geophysical Union to "an individual who has made significant, consistent, and lasting contributions of high quality in science journalism, particularly in the coverage of sub...Study examines role of EGFR gene mutations in lung cancer development
A new study has found that mutations in either of two genes are involved in the development of lung cancer. One of them is the first known mutation to occur specifically in never smokers, according to a new study in the March 2 issue of the ...... Studies have found that the epidermal growth factor receptor (EGFR) gene is mutated in many nonsmall-cell lung cancers and that these mutations are as...