Bacterial protein shows promise in treating intestinal parasites
...es discovered five years ago that the roundworm C. elegans and other nematodes are susceptible to the effects of Cry5B, then known primarily as an insecticide. The toxin forms tiny holes in the membranes of the cells of nematodes and insects. However, since the toxin can't bind to the cells of mammals or oth...News tips from the Journal of Neuroscience
1. Probing the Thermotaxis Circuit in C. elegans Atsushi Kuhara and Ikue Mori The relative simplicity of the nervous system in Caenorhabditis elegans provides some advantages in elucidating the molecular and cellular underpinnings of learning and me...NYU biologists identify gene that coordinates two cellular processes
...ic tools to study the nematode worm Caenorhabditis elegans (C. elegans), the first animal species whose genome was completely sequenced and a model organism to study how embryos develop. The study appearing in Current Biology was performed by NYU's Fabio Piano, an assistant professor, and Anita Fernandez, a...Scientists discover age-regulated cellular activities that protect against protein aggregation
... these diseases. The new study-conducted in a C. elegans model, a roundworm that expresses a protein whose aggregation appears to cause Alzheimer's disease-showed that toxicity from protein aggregation is "drastically reduced" when aging is slowed by modulating the insulin growth factor (IGF) signaling pat...Key fat and cholesterol cell regulator identified, promising target
...H Cancer Center, the team demonstrated that the C. elegans homologues of SREBP and ARC105, known as SBP-1 and...The striking effects of the RNAi knock downs in C. elegans suggest that the ARC105/SREBP pathway may play a key role in lipid production in humans," said Lauri...'Friend' protein keeps nerve signals in check
...leagues used the soil nematode worm Caenorhabditis elegans to study the function of tomosyn using a recording...trength of the synapse." Because the nematode C. elegans uses proteins in its nervous system comparable to those in humans, Richmond suspects that forthcomin...Parkinson's disease mechanism discovered
...icity in the fruitfly Drosophila, the roundworm C. elegans and in cultures of rat neurons. Bonini and her colleagues tested the effect in fruitflies; co-author Guy Caldwell and his colleagues at the University of Alabama performed the tests in roundworms; and co-author Jean-Christophe Roche and his colleague...Researchers reverse Parkinson's symptoms in animal models
...ortium tested this hypothesis in the fruit fly, C. elegans worm, and in neurons culled from rats--all of which had alpha-synuclein-induced Parkinson's symptoms. In every case, symptoms were reversed by increasing levels of this transport protein. "We tried this a number of different ways, from creating tran...U. of Colorado team solves mystery of carcinogenic mothballs
...h scientists in research labs around the world, C. elegans worms have essentially the same basic biological p...e days, he said. Xue's team currently is using C. elegans as an animal model "bioassay" to test common industrial chemicals like biphenyl, toluene and benzene...Starvation response in worms points to common hunger pathway
...es the enzyme MAPK in the pharyngeal muscles of C. elegans through a muscarinic acetylcholine receptor. Mutat...mechanisms that mediate starvation responses of C. elegans pharyngeal muscle are conserved across phylogeny," Ashrafi said. The findings might help to unravel ...Worm's hunger response provides clue to eating disorders
...x to suck in its prey. When it can't find food, C. elegans reacts by pumping the pharynx harder. "Despite th...although mice and humans have five types, while C. elegans has only three. When mice, for example, are genetically altered to lack the gene for one type of mu...Understanding the life of C. elegans
... (April 4, 2006) When the nematode Caenorhabditis elegans has enough to eat, enjoys the right temperatures a...articular ligands promote the maturation of the C. elegans reproductive capacity and prevent the organism from going into the immature long-lived larval phase ...For the first time: Longevity modulated without disrupting life-sustaining function
...am identified a protein in the worm Caenorhabditis elegans that allowed them to do just that. The protein is encoded by the Smk-1 gene. "Smk-1 is the first known gene that regulates longevity without affecting other vital functions of the insulin signaling pathway," said Wolff. Under favorable conditions, a...Worm hormone discovery may aid fight against parasitic disease
...rmones." The dauer diapause occurs naturally in C. elegans when the worm senses from its environment that con...man disease because the dauer diapause stage of C. elegans is very similar to the infective state of parasitic nematodes. According to the World Health Organiz...Biologists develop genome-wide map of miRNA-mRNA interactions
...rgets in the animal model organism, Caenorhabditis elegans (C. elegans). MicroRNAs bind to messenger RNA (mRN...U, the researchers predicted miRNA functions of C. elegans genes. The researchers found that one-third of C. elegans miRNAs target gene sets have related funct...News tips from the Journal of Neuroscience
...istone Deacetylases and Huntingtin Toxicity in C. elegans Emily A. Bates, Martin Victor, AdrianaK. Jones, ...ption. The authors used transgenic Caenorhabditis elegans that expressed an expanded polyglutamine fragment of human huntingtin (Htn-Q150) in a subset of sen...X chromosome dosage compensation proven in germ cells
...osome. The study shows that this also occurs in C. elegans and mice somatic cells. In human female somatic cells, one of the two X chromosomes is inactivated to equilibrate expression between the sexes, but this unbalances the expression of the X compared to the other chromosomes. This study is the first dem...A clue to core problem of neurodegenerative disease and cell death
...nisms, findings made in model organisms such as C. elegans are often the first step in understanding the molecular roots of human diseases."...Turkish scientist's discovery of how proteins work
...anisms of Programmed Cell Death in Caenorhabditis elegans ." Yan was born in Jinan, China, in 1977 and grew up in Beijing. As an undergraduate at Tsinghua University, she developed a strong interest in science and was also deeply influenced by Beijings unique civil milieu. After receiving a bachelors degree......non-protein-coding RNAs in the model nematode, C. elegans . They characterize 100 heretofore-undescribed tra...gulation, small non-coding RNAs (or ncRNAs) in C. elegans have not been extensively investigated until now. Using a new, high-throughput procedure to clone ...