Essential genes for embryogenesis uncovered in major mouse mutagenesis project
...icated that 6-10% of zebrafish genes and 7% of C. elegans genes are required for prenatal survival. "The higher percentage of embryonic lethal genes in mice may reflect an inherently more complex or sensitive process of development," report the scientists. The project included major contributions from Sch...Discovery at UCSB may lead to new drugs to treat cancer, control fertility
...ell fusion." Rothman studies the nematode worm C. elegans as a model organism. His research group looks at genetic mutations to see what effect they cause. From that information they can determine which genes are involved in certain biological processes. The mutation they found in this discovery is one that...Program finds lost genes in nematode genome
...oftware, TWINSCAN, on the genome of Caenorhabditis elegans (C. elegans). The genome of another nematode C. br...INSCAN predicted 60 percent of the genes in the C. elegans genome exactly, right own to the last amino acid. "This (60 percent) is a new level of acc...Signs of aging: Scientists evaluate genes associated with longevity
...The researchers hope that their observations in C. elegans will contribute to our understanding of human agin...ill also be utilized to more fully annotate the C. elegans transcriptome, resulting in a refined estimate of gene number and organization in this species....Nobel Laureate Sydney Brenner receives 2005 UCSD/Merck Life Science Achievement Award
.... He also showed that the tiny transparent worm C. elegans was useful for studying how cells specialize and organs develop. During his career, Brenner also demonstrated that a chemical could produce specific genetic mutations in the worm, allowing different mutations to be linked to specific effects on organ...Scientists identify genetic pathways essential to RNA interference
... School. RNAi was originally identified in the C. elegans roundworm and the flowering plant Arabidopsis thal..., PhD, and his colleagues developed a strain of C. elegans into which they added a gene that caused the worms to glow under ultraviolet light but also turned t...Gladstone scientists announce new version of bioinformatics software program
... Drosophila (fruit fly), mouse, rat, zebrafish, C. elegans (a microscopic roundworm), and S. cerevisiae (yeast). Species-specific gene databases that show relationships between the various gene ID systems in the database. For example, genes on the MAPP (GenMAPP files that represent biological pathways or g...Critical role in programmed cell death identified
... fragmentation is critical in killing cells. C. elegans worms are a convenient model system, Conradt explained, with a well documented cell lineage that facilitates genetic manipulation. Their cell death machinery is simple, with one component for each of the different factors involved in the central ce...UCSD discovery may help extend life of natural pesticide
...de. "Our previous findings with the roundworm C. elegans strongly suggested that specific sugar structures ... Aroian credit the flexibility of the roundworm C. elegans as an experimental system, particularly the ease of manipulating it genetically, in making it possib...Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits
... Saccharomyces cerevisiae ), worm ( Caenorhabditis elegans ), and fly ( Drosophila melanogaster ) proteins with 38,965 known interactions. Their PathBLAST tool generated a list of similar proteins in the three species that were involved in similar interactions: there were 183 protein clusters and 240 communi...Researchers find new genes necessary to make embryo
... NYU, is studying the genome of the Caenorhabditis elegans (C. elegans), the first animal species whose genom...majority of genes required for embryogenesis in C. elegans have counterparts in humans whose roles are often unknown. For example, human counterparts of four o...Anti-seizure drugs slow aging in worms
...g activity." The researchers grew the roundworm C. elegans in the presence of the 19 drugs and found that an ...tists previously had found genetic mutations in C. elegans that affect both the nervous system and life span. The researchers used these mutant worms to furthe...Laser scalpel opens way for nerve regeneration studies in worms
...snipped apart a single neuron in the roundworm C. elegans -- an achievement that opens a new avenue for stu...nity to use the well-characterized genetics of C. elegans to study the basic mechanisms of nerve regeneration," said Jin. "Until now there has been little st...Femtosecond laser technique opens new opportunities for research on neural regeneration
...ely thought of my work on the nervous system of C. elegans and came up with a nerve regeneration experiment w... body. The researchers who pioneered the use of C. elegans for biomedical research received the 2002 Nobel Prize for physiology and medicine. Now this excelle...Studies in Royal Society journals include stress in birds and depletion of medieval fish stocks
...itness cost of extended lifespan in Caenorhabditis elegans by Dr GJ Lithgow, Dr NL Jenkins and Dr G McColl I...wever, some mutants of the nematode Caenorhabditis elegans have a doubled lifespan without obvious side effects on development and fertility. We made such lon...U-M researcher examines the cell's housekeeping habits
...periments in which autophagy was blocked in the C. elegans nematode worm resulted in dramatically shorter life spans for the 1 millimeter creatures. Conversely, more autophagy may prolong life. This fits with findings that caloric restriction can extend the life span in rats, since near-starvation triggers m...Genetically endowed worm may substitute for rodents in some toxicology testing
....C. -- A primitive roundworm called Caenorhabditis elegans (C. elegans) is being evaluated in a Duke Universi...inds of toxicity. In its natural environment, C. elegans spends its brief life dining on microbes in the soil. But Jonathan Freedman of Duke's Nicholas Schoo...Research into the sense of touch in worms wins Eppendorf/Science Prize
...ty of Chicago, she pursued postdoctoral work in C. elegans neurophysiology and genetics at the University of Oregon and Columbia University. Currently, Dr. Goodman is an Assistant Professor of Molecular and Cellular Physiology at Stanford University. Work in her laboratory focuses on delineating the molecula...