Diabetics susceptible to compromised cardiovascular function from high levels of air pollution
.... Specifically, on days when sulfate pollution was elevated the researchers found an 11 percent decrease in vascular reactivity among diabetic participants. On days when black carbon concentrations were elevated, diabetic study participants had a 13 percent decrease in vascular reactivity. In comparison, non-...Study establishes new class of cancer-causing genes
...at idea directly, the researchers examined whether elevated expression of mir-17-92 or other microRNAs could accelerate the onset of cancer and/or decrease survival in a mouse model of B-cell lymphoma. As expected, control animals developed B-cell lymphoma after about 2 months, and the overall survival of thi...JCI table of contents July 1, 2005
... congenics in which there is T cell hyperactivity, elevated CD4:CD8 ratios, and anti-nuclear antibodies. The researchers demonstrate that these B6.Sle3 congenic mice exhibit heightened T cell expansion in vitro upon antigen challenge, mediated by hyperstimulated antigen presenting cells. The congenic-deriv...New study demonstrated add-on effects of ACTOS (pioglitazone HCl)
...L and lower triglycerides. Low HDL cholesterol and elevated triglycerides represent cardiovascular risk factor...ple with type 2 diabetes. The pattern consists of elevated triglycerides, reduced levels of HDL cholesterol, normal or slightly-elevated levels of total and LD...Engineered skin offers clues to melanoma development
...a. The scientists also investigated the role of elevated telomerase activity. In combination with other cancer genes, hTERT, the active protein in the enzyme telomerase, caused progressively invasive melanoma. In contrast, melanocytes that did not receive hTERT remained in an early stage of benign growth. ...Physical and functional interaction of key cell growth molecules linked to cancer
...side the cell. EGFR is often present at abnormally elevated levels in human cancer cells. Increased EGFR acti... inducible nitric oxide synthase (iNOS). Although elevated iNOS is also a key characteristic of many human malignancies, there has previously been no direct co...Aerobic exercise helps find genetic regions linked to prediabetes
...logia. Prediabetes is characterized by the body's elevated resistance to insulin, the hormone that regulates blood glucose levels and energy storage. The condition generally advances to type 2 diabetes as the pancreas works to secrete insulin to compensate for increased insulin resistance in the body's liver...JCI table of contents July 1, 2005
...smitter storage and release in vivo. The mice had elevated blood pressure that could be restored to normalcy by treating the mice with human CHGA, demonstrating that the human gene plays a role in autonomic control of blood pressure. An accompanying commentary by Taeyoon Kim and Y. Peng Loh states that one ...Urine test may help monitor disfiguring birthmarks
...er lab also demonstrated that cancer patients have elevated levels of MMPs in their urine. Because vascular an...MPs known as the high-molecular-weight MMPs were elevated in the urine of 53 percent of patients with vascular tumors and 41 percent of those with vascular ma...Forsyth scientists find three bacteria associated with oral cancer
...7 Journal of Translational Medicine, suggests that elevated levels of three particular bacteria in saliva indi...ad been diagnosed with oral cancer. The team found elevated levels of three bacterial species (C. gingivalis, P. melaninogenica and S. mitis) in oral cancer pat...42 biomedical scientists worldwide named HHMI international research scholars
...gate the processes that induce the body to produce elevated numbers of CD8+ memory cells, which are key to the function of the human immune system. This study could have significant impact on how vaccines are developed in the future. * Charles Boone, Ph.D. Professor Banting and Best De...Melbourne scientists dominate international Howard Hughes Medical Institute awards
...ntigen presenting cells induce the body to produce elevated numbers of CD8+ memory T cells during acute and persistent viral infections. These memory T cells are vital to long-term protection of the body against subsequent viral infection. Professor Geoff McFadden; The University of Melbourne : to investigat...Acetaldehyde may be the culprit behind hangovers
...re more likely to report alcohol flushing and have elevated MCV, both of which are indicators of high acetaldehyde exposure due to drinking in persons with inactive ALDH2." In other words, individuals with inactive ALDH2 do not appear to have the capability to eliminate acetaldehyde from their systems, which ...DFG establishes 11 new research units
...tists will study their load-bearing capacity under elevated temperatures and pressures as well as potential applications in comparison to conventional packing structures. The Research Unit "High Frequency Parasitic Effects in Converter-Fed Electrical Drives" at the Technical University of Darmstadt will inves...Ferry-linked water monitoring system becomes new model for United States
...t that there are predictions of several decades of elevated tropical storm activity, the timing couldn't be better for continuing to take a serious look at North Carolina's remarkable water resources in the east," he said. "Our state's previous commitment to FerryMon was a wise decision." Among the benefits o...Unique interplay between tumor and blood vessel cells promotes angiogenesis and tumor growth
...r cells was not sufficient to induce angiogenesis, elevated levels of Jagged initiated crosstalk between tumor cells and blood vessel cells and stimulated tumor growth and new blood vessel formation. "Our studies suggest that in addition to the secretion of proangiogenic growth factors, tumor cells may expres...Elevated temperature enhances success of viral cancer therapy
...viral therapy after they have been incubated at an elevated temperature. The findings could have a significant...pharmacologically or by incubating the cells at an elevated temperature similar to that experienced by humans when they have a fever, the RNA export function wa...Study reveals trigger for insulin resistance in liver, potential drug targets
...y. Fatty liver can lead to altered liver function, elevated lipids such as cholesterol and triglycerides in th...triglyceride content in humans, we've learned that elevated liver fat is fairly ubiquitous in patients with poorly controlled type 2 diabetes," Shulman said. "I...Insulin pulses keep the liver lean
...cts of CEACAM1 might help to alleviate chronically elevated blood and liver lipids in patients with diabetes.......ivity. About 25 percent of people with autism have elevated levels of serotonin in their blood. Selective serotonin reuptake inhibitors (SSRIs), drugs used to treat depression, anxiety and obsessive-compulsive disorders, also improve some of the symptoms of the disorder. These findings have led scientists to ...