Muscle of obese 'programmed' to amass fat, genetic study finds
... The newly discovered elevation in enzyme activity elucidates an important link between obesity, diabetes, and abnormal fat buildup in muscle, said study author Deborah Muoio of the Sarah W. Stedman Nutrition and Metabolism Center at Duke University Medical Center. "Obesity and type 2 diabetes are strongly asso...Variation in HIV's ability to disable host defenses contributes to rapid evolution
...ariation in the virus within patients. "This work elucidates new pathways which shape the evolution of the virus," says Viviana Simon, lead author of the study....Excess liver gene protects against high-fat diet
... lipid metabolism," said Lazar. "The current study elucidates a previously unrecognized role for these liver receptors in the links between diet, serum lipids, and atherosclerosis." Selective modulation of the LXR target genes in liver may therefore ameliorate high lipid levels and cardiovascular disease, the r...New findings in innate immunity may lead to treatments for atherosclerosis
..."Our finding sets IRAK1 apart from other IRAKs and elucidates a novel pathway in innate immunity regulation," says Dr. Li. Because atherosclerosis patients usually have elevated serum IL-10 levels, the scientists also looked at IRAK1 levels in blood from atherosclerosis patients. They found that IRAK1 is modifi...