Embryonic stem cells correct congenital heart defect in mouse embryos
...t that 15 embryonic stem cells injected into early embryos of mice whose hearts were genetically predisposed ...pment in the Id knock-out embryo. The Id knock-out embryos were born, but with partial rescue of cardiac defects and abnormal gene expression profiles. As a re...'Junk' DNA may be very valuable to embryos
...t expression of genes in mouse eggs and very early embryos is activated in part by regions of DNA called retrotransposons, which may have originated from retroviruses. These regions, found in DNA of human, mouse, and other mammals in hundreds of thousands of copies, are called retrotransposons because they...Workshop on Responsible Stem Cell Research
...ursuing studies on stem cells derived from donated embryos and not included in the approved lines. Several st...use and handling of stem cells derived from frozen embryos originally intended for in vitro fertilization procedures, as well as those derived from a process s...Channel protein converts vibrations to electrical signal
...th the production of the protein in both zebrafish embryos and hair cells from mice. To test function, the researchers bathed the embryos or the mouse cells in a solution containing a dye either yellow or red that can pass through the i...Muscling in on a deadly cancer
...khr gene in mouse muscle satellite stem cells, the embryos didn't develop tumors. That makes satellite cells ... muscle fibers either late in development of mouse embryos or after the mice were born. Second, they inactivated either one of two tumor-suppressor genes name...Babies born after surgery on eggs
...l type to another. For instance, in eggs and early embryos mitochondria do not replicate, while they do in granulosa cells. More seriously, he says the group should have done more extensive experiments on animals to evaluate the long-term health effects. "I think that work needs to happen," Cohen says. "Then...Ethical paradigm: Relating embryonic stem cell use to organ donation
... humans. The authors highlight the point that many embryos created for in vitro fertilization are not used because they are unable to properly produce a fetus due to inherent genetic or mechanical defects. These embryos, however, often contain some normal cells that, while unable to create a fully formed hu......Three-dimensional preservation of algae and animal embryos in a Neoproterozoic phosphorite," Nature, v. 391)....a Tech. But what kind of adult would these ancient embryos have hatched into? In 2000, Xiao's team reported the discovery of a coral-like animal that might be ...JCI table of contents November 1, 2004
... humans. The authors highlight the point that many embryos created for in vitro fertilization are not used because they are unable to properly produce a fetus due to inherent genetic or mechanical defects. These embryos, however, often contain some normal cells that, while unable to create a fully formed hu...A 'repulsive' protein guides blood vessel development
...ion of Sema3E protein in specific regions of chick embryos prevented vascular growth into those areas. "Sema3E is a very potent chemorepellent for developing blood vessels," Ginty noted. "So, one possibility is that drugs that mimic this function could be useful in preventing growth of the new blood vessels ...Heart protein could be used to repair damage caused by heart attack
...ies. The protein, Thymosin beta-4, is expressed by embryos during the heart's development. It encourages the migration of heart cells and affects those cells' survivability. The new findings show that the protein prevents cell death after an experimentally-induced heart attack and limits the degree of scar t...Efforts to clone primates move forward
...oratory to nonhuman primate eggs. Resulting cloned embryos progressed to the blastocyst stage, a developmenta...eved. Dr. Schatten's group made 135 cloned monkey embryos and transferred them into 25 surrogate female rhesus macaques. No pregnancies were established. Univ...Neural crest stem cells in skin could provide alternative to embryonic stem cell use
...heir use, however, raises ethical concerns because embryos are being destroyed in the process. In contrast, neural crest stem cells from adults have several advantages: similar to embryonic stem cells, they have the innate ability to differentiate into many diverse cell types; they are easily accessible in ...New model of rare childhood blindness holds promise for testing preventive therapies
...e AIPL1 in mouse embryos, disrupting the gene. The embryos were then inserted into female mice that gave birth to mice with this genetic defect. Using a variety of laboratory methods to study retinal cells, the team showed that AIPL1-deficiency causes severe retinal degeneration beginning around ...Fundamental finding yields insight into stem cells, cancer; opens door to drug discovery
...ir experiments, the researchers injected zebrafish embryos with a chemical that specifically blocked the func...opmental pathways, the researchers said. Zebrafish embryos are an ideal model for study because their transparent embryos allow researchers to easily observe t...Highlights of January 2005 issue of Biology of Reproduction
...osphate on cleavage past the 2-Cell stage in mouse embryos from outbred and F1 hybrid females." Timin Hadi, M... Baltz. For many years it has been a puzzle why embryos from most random-bred and inbred female mice exhibit a block at the 2-cell stage in classical embryo...Zebrafish may hold key to understanding human nerve cell development
...the consequences of gene defects in the 200 to 300 embryos each female fish produces," she said. By studying these mutant embryos, Piotrowski and her colleagues discovered that during development the zebrafish is "seeded" with future hair cells through a process known as placode migration. These precurso...Researchers tease out one critical role of tumor-suppressor gene
...d macrophages taken from the liver tissue of mouse embryos bred to lack Rb. Macrophages are scavenger cells -...d that the reason why the red blood cells from the embryos without Rb never lost their nuclei was due to a reduction in the number of macrophages in these feta...The simple truth: Animal development not as complicated as it seems
...rprisingly simple patterns of cell division in the embryos of small invertebrates is described in a paper tit...d by a computer program. They found that the real embryos did not behave like the computer-generated ones, but instead showed that these organisms took fewer ...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...ch and her colleagues treated developing surf clam embryos ( Spisula solidissima ) with different combination...induce the greatest adverse response. Treating the embryos with the triple mixture resulted in increased production of a subunit of an enzyme called protein ki...