Researchers discover 'acquired' DNA key to certain bacterial infection
...ult in serious lung infections and is prevalent in emphysema and AIDS patients among others infects tissue cells or macrophages and thus compromises the bodys immunity. Results of the study, led by researchers at Oregon State University, will be published online this week in the Proceedings of the National ...UT-Houston scientists develop new procedure to differentiate human embryonic stem cells
... distress syndrome of the newborn, alpha-1 related emphysema and cystic fibrosis, Wetsel believes. All three of these diseases are caused by single gene defects and therefore have been logical candidates for gene therapy, Wetsel said. Respiratory distress syndrome of the newborn, a condition affecting prema...NIH gives PITT $13 million grant for chronic obstructive pulmonary disease research
...y (QCT), researchers will study airway remodeling, emphysema and their associations with other functional and physiological indicators of COPD to define unique clinical subcategories related to the interactions of genetic and environmental characteristics in 800 study subjects. Studies will include associated ...Gene therapy for hereditary lung disease advances
...s. Alpha-1 deficiency can in some patients lead to emphysema and cirrhosis, both progressive diseases that can be fatal. Alpha-1 patients with symptoms of emphysema can be treated through weekly intravenous injections of alpha-1 protein derived from human plasma. T...Non-steroidal anti-inflammatory drug increases liver damage in mice carrying mutant human gene
... because they are at increased risk for developing emphysema at a young age. In addition, some patients with alpha-1-antitrypsin (AT) deficiency can develop serious liver disease. But predicting which of them are at risk for liver disease is not yet possible. Now research performed at Washington University S...Lungs try to repair damaged elastic fibers
...racterize the regions of the lung showing moderate emphysema and regions showing severe emphysema. They found that new elastin synthesis was initiated in moderately diseased specimens. The researchers did a second study using 10 lungs from end-stage COPD patients who had undergone transplants. Again, they fo...Genetic disorder linked to rapid lung function decline in some World Trade Center rescue workers
..., New York, NY. "Some with the defect will develop emphysema early, even without cigarette smoking. Others, wit...tional environmental irritants in order to develop emphysema and other forms of obstructive airway disease." Dr. Banauch and colleagues followed 90 World Trade...JCI table of contents: October 19, 2006
... provides new insight into the mechanisms by which emphysema develops, but further work is required to determin...: Toll-like receptor 4 deficiency causes pulmonary emphysema AUTHOR CONTACT: Patty J. Lee Yale University School of Medicine, New Haven, Connecticut, USA. Phon...New approach allows closer look at smoker lungs
...tions such as emphysema, bronchitis and asthma. In emphysema in particular, the alveoli - tiny sacs in the lungs that transfer oxygen to blood - gradually break down. Fain and his team therefore reasoned that helium gas molecules are likely to have more space to move around in lungs with fewer functioning alv...Blood pressure medication may revolutionize treatment of Marfan syndrome
...e could develop problems that resemble destructive emphysema - which involves widening of the air spaces and can lead to rupture of the lungs. When they examined the lungs of their mice, they expected to see evidence of destruction and inflammation in the lung tissue, said Dietz. They did not think they would ...Researches discover gene critical for protection against septic-shock-induced death
...lammatory diseases such as cigarette-smoke-induced emphysema and allergic asthma in mice models. Biswal's team found that the deletion of the Nrf2 gene increased the inflammatory response and caused early death in mice subjected to septic peritonitis or endotoxin shock or both. Mice deficient in Nrf2 gene exp...JCI table of contents, February 9, 2006
...R'S PICK The smoking gun: elastin fragments drive emphysema Pulmonary emphysema is caused primarily by cigarette smoking, and the underlying cellular mechanisms are thought to invo...Tomato juice keeps emphysema from developing in new model; Lycopene cited
...ing tomato juice to mice kept them from developing emphysema after cigarette smoke exposure that was long enough to induce emphysema in a control group, Japanese researchers report in February issue of the American Journal of Physiol...JCI table of contents December, 2005
...d=24394 IMMUNOLOGY Coughing up a new player in emphysema The cytokine IFN-gamma helps regulate the immune ...duced inflammation. Further, the authors show that emphysema due to cigarette smoke exposure occurs via IFN-gamma-dependent mechanisms and this response is decre...First report of cancer drug Gleevec as new target therapy for pulmonary hypertension
...ative diseases such as atherosclerosis, COPD, lung emphysema or lung fibrosis. Larger clinical trials in a controlled design to test Gleevec's safety and effectiveness are currently in preparation under the scientific lead of the Giessen lung researchers, who also signed largely responsible for the recent appp...Most common lung cancers may begin in newly discovered cells
... to new therapies for other lung diseases, such as emphysema and cystic fibrosis. "We tend to emphasize cancer, because we are in a lab that studies cancer," Bender Kim said. "Identifying stem cells is the biggest part of the story. This population could be very useful for more than cancer." In their paper, th...SERPINE2 identified as novel candidate gene for COPD, especially with smoking
...ve an increased risk of developing COPD, including emphysema and chronic bronchitis. Certain individuals are more susceptible than others, in that they have an increased risk of developing disease in response to smoking. For instance, people with a rare form of the protein made by the gene alpha-1-antitrypsi...'Lighter than air' breathing more than doubles COPD patients' exercise endurance
...ic obstructive pulmonary disease (COPD, defined as emphysema and chronic bronchitis) as a single cause of death around the world shares fourth place with HIV/AIDS, following coronary heart disease, cerebrovascular disease and acute respiratory infection. WHO estimates that 2,740,000 people died of COPD worldwi...JCI table of contents November 1, 2004
.... To investigate the impact of oxidative stress on emphysema development, Shyam Biswal and colleagues, from Joh...ge. The authors found that cigarette smoke-induced emphysema was of earlier onset and more widespread in the Nrf2/ mice than in their wild-type littermates. The ...Gene that blocks free radical damage protects against emphysema
.... To investigate the impact of oxidative stress on emphysema development, Shyam Biswal and colleagues, from Joh...ge. The authors found that cigarette smoke-induced emphysema was of earlier onset and more widespread in the Nrf2/ mice than in their wild-type littermates. The ...