Tag: "endocrine" at biology news
Washington State University study points to role of toxins in inherited disease
...hlor, a pesticide that replaced DDT are known as endocrine
disruptors, synthetic chemicals that interfere wit...r effects. Pregnant rats that were exposed to the endocrine
disruptors produced male offspring with low sperm counts and low fertility. Those males were still a...
Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
...tants that mimic the action of hormones (so called endocrine
disrupting chemicals) might interfere with human development at this stage and cause congenital abnormalities, infertility and possibly cancer (in particular testicular cancer). By developing suitable tests with embryonic stem cells as they different...
JCI table of contents July 1, 2005
...d environment for up to 5 weeks, isolated from the endocrine
and nutritional influences of their donor, retained their donor's metabolic characteristics. This suggests that defects in switching between fat oxidation and carbohydrate oxidation, possibly due to genetic defects in skeletal muscle, contribute to o...
APS oxytocin/vasopressin conference: 13 highlighted presentations
...look at endocannabinoids involvement in autonomic, endocrine
and immune function. The Edinburgh group led by Nancy Sabatier is studying endocannabinoids' influence on oxytocin and social behavior. "Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and GABA inputs to hy...
OT, VP studied as novel psychiatric drug sources; consider gender-specific drug models
...cal researchers have long recognized the important endocrine
roles played by the pituitary hormones oxytocin (OT) and vasopressin (VP) on peripheral systems in lactation, uterine contraction and urine concentration. Over the past few years, neuroscientists have begun reporting evidence solidifying the possible...
Endocannabinoids the brain's cannabis demonstrate novel modes of action to stress
...nduced responses such as the changes of autonomic, endocrine
and immune function." Furthermore, Soya added, "cannabinoids are relevant to potential relief in such disease situations in the brain as multiple sclerosis and epilepsy, or feeding disorders. In these, their effects are similar to marijuana, except f...
Researchers outline possible drug targets for treating metabolic syndrome
...the treatment of cancer, dermatological disorders, endocrine
disorders and some aspects of the metabolic syndrome. In their review article, Drs. Mangelsdorf and Shulman outline promising research findings on how drugs that target RXR complexes may be used in the management of the metabolic syndrome. One of th...
Leptin-signaling protein maintains normal body weight and energy balance in mice
...thalamus the part of the brain that regulates the endocrine
system and the autonomic nervous system. In response, neurons in the hypothalamus send out chemical signals called neuropeptides, which suppress appetite and make us stop eating. When the system works properly, the body maintains a natural balance be...
Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
... and some reports have implicated them as possible endocrine
disruptors. Many of these compounds cannot be destroyed by existing means. The catalyst, one of a family of catalysts called Fe-TAMLs (TAML stands for tetra-amido macrocyclic ligand), works with hydrogen peroxide. Its "green" design is based on elem...
One shot: A molecular movie of events that enable sperm to penetrate egg's coating
...es the same basic fusion molecules as neuronal and endocrine
cells. However, AE is much less complicated than fusion in these other cell types because it only happens once; other cells secrete the same substances again and again, requiring the fusion machinery to recycle multiple times. The team evaluated the ...
Tobacco industry weakened pesticide regulations, UCSF study shows
...data supported. Zoecon manufactures methoprene, an endocrine
disruptor that prevents the larvae of cigarette beetles and tobacco moths from maturing. At Phillip Morris' insistence, the company asked for and obtained residue limits of 15 ppm in tobacco when its own data supported a level of 10 ppm. Zoecon also ...
Hormones and growth: The control of body size and developmental growth rate in fruit flies
...d that the release of the hormone ecdysone from an endocrine
organ called the prothoracic gland triggers larval...ctivated form of the signaling molecule Ras in the endocrine
prothoracic gland. This precocious ecdysone release caused flies to develop more rapidly and exhibit...
EU research suggests that PCBs damage sperm but finds no dramatic effect on male fertility
...need are data on exposure of unborn babies, as the endocrine
disruption hypothesis suggests that foetal and peri-natal exposure could be more relevant as far as health and reproductive consequences are concerned," he said. He added that there were few epidemiological studies of the reproductive effects of POPs...
Researchers find gland that tells fruit flies when to stop growing
...n Mirth, found that the prothoracic gland, a major endocrine
organ situated just in front of the brain, assesse... assessment had to be accomplished through a major endocrine
organ, so they screened all fruit fly endocrine
glands, enlarging or reducing them and studying the ...
Nine minority physiology grad students each get $18,000 Porter Fellowship from APS
...oD1 directs these cells to develop into intestinal endocrine
cells. Endocrine cells in the intestine regulate m...h will provide insight into how molecules regulate endocrine
cell differentiation in the intestine. Jeffrey Mason University of California Davis Mr. Mason's ...
New monoclonal antibody therapies offer significant survival advantage for breast cancer patients
...n with hormone receptor positive disease, adjuvant endocrine
therapy (most commonly tamoxifen) followed chemotherapy. The average age of study participants is 49 years. The aim of this trial is to compare the effect of 1 year of Herceptin infusions, given every 3 weeks, with one year of simple observation, on ...
Gemcitabine and capecitabine improved overall survival in patients with advanced pancreatic cancer
...zymes for the digestive system), others affect the endocrine
system, the release of hormones such as insulin. Pancreatic cancer is difficult to treat and is often resistant to chemotherapy and radiotherapy. Normally surgical removal of the cancer is the best chance for patients and the most widely used surgica...
Olfactory input dominates reproductive behavior in mice
...nce on LHRH neuronal activity, and in turn, on the endocrine
control of reproduction," Dulac says. "Although not previously documented, it appears that olfactory activity plays an essential role in eliciting male mating behavior with females." Dulac says this finding helps explain a paradox in humans, which la...
A spoonful of sugar makes some kids feel good
...with regard to a wide variety of physiological and endocrine
differences, and future studies should identify variables that promote or impede the ability of sweet taste to act as an analgesic in both children and adults."...
Gene variation affects tamoxifen's benefit for breast cancer
... be used to identify patients likely to respond to endocrine
therapy, including tamoxifen. This group is led by David A Flockhart, M.D., Ph.D. at Indiana University School of Medicine. More than 210,000 women in the United States will develop breast cancer. Approximately 70 percent of these cancers are fueled ...
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