Shutting down the HIV assembly line
... have demonstrated that Gag is present in the late endosome and have focused on particle assembly at that point, none have tackled how the Gag protein gets there in the first place. The current work fills this gap. Spearman and colleagues used the HIV-1 Gag protein as bait to "fish" for Gag binding partners. ...UCSB researchers discover that the cell's endosomes use a surprising transportation system
...ependent on endocytic transport. Understnading how endosome distribution evolves is central to such therapeutic approaches....New, more direct pathways from outside the cell-to-cell nuclei discovered
...nd intracellular compartment, which is known as an endosome or phagosome. It was also already known that material can migrate out of an endosome or phagosome and eventually enter the cell nucleus. But the Brooklyn College team has discovered tha...