Leading cause of US food-borne illness makes its own pathway through cells
...mes breaks it down. By monitoring markers for this entry pathway, Watson and Galn could watch as the microbe infected a host cell, briefly associated with the early marker protein EEA-1, and then with the late marker Lamp-1. "Although the marker proteins indicated that campylobacter trafficked to convent......rnational leaders in their field, that examine the entry and persistence of gene therapy vectors in target cells. In spite of continued great difficulties with technical implementation, initial successes in somatic gene therapy are on the horizon, for example in treating adenosine deaminase deficiency and...Androgen therapy may slow progress of Alzheimer's disease
...estosterone is rapidly converted to estrogen after entry into neurons, the new data are logical, and they dovetail well with historical data." Using a mouse model of AD, in which three genes had been altered, researchers evaluated how experimental manipulation of sex hormones affected the progress of the ...Too mellow for our predatory world
...ational Park Management is considering raising the entry fee from the currently charged $100 to $500 in order to reduce the number of visitors - possibly the only possibility to create sustainable tourism, thereby ensuring the necessary protection of the unique animal and plant world of the Galápagos....Study helps explain why botulinum toxin is so deadly
...eceptor for one botulinum toxin was a key point of entry into the nerve cell. Dong shares first authorship on the current study along with Qing Chai and Joseph Arndt of Scripps. The Nature paper is an elaboration on that 2003 discovery, which was published in The Journal of Cell Biology. Stevens's lab bomb...First familial pancreatic cancer gene identified
...cancer gene" provides researchers with a molecular entry point into the cellular processes underlying this cancer and will hopefully help to improve diagnosis and development of new treatments for this deadly disease....A molecular condom against AIDS
... incorporate experimental anti-AIDS drugs known as entry inhibitors into the molecular condom....Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity
...ibing complex with the addition site available for entry of a matched NTP. Those crystals uncovered a secon...inding site on the transcribing enzyme, dubbed the entry site. While all NTPs can bind the entry site, only an NTP matched for base-pairing with the DNA temp...Study finds periodontal treatment does not lower preterm birth risk
...of whom were between 13 and 17 weeks pregnant upon entry into the study. Each woman was randomly assigned to receive either: (1) scaling and root planing of the teeth prior to the 21st week of pregnancy, then monthly tooth polishings or (2) scaling and root planing after delivery, meaning women in this g...Molecular mechanism provides intra-cellular traffic signal
...flow. One form of TRAPP turns on the first Ypt for entry into the Golgi, while at the other end of the Golgi, two subunits join TRAPP to activate the Ypt required for exit from the Golgi, Segev said. Segev said the mechanism that her lab identified must now be shown to exist in mammalian cells. Her earli...Hopkins researchers uncover critical player in cell communication
...er the cell. "We think TFII-I must control calcium entry into the cell by somehow limiting the number of calcium channels at the cell's surface," says Desiderio. "There's good evidence suggesting that the frequency and intensity of this ebb and flow of calcium can determine a cell's response to external ...Open Science Grid receives $30 million award
...developers of campus and regional grids points of entry to the grid for university scientists and students are beginning to use the OSG environment to provide access to their resources." Scientists from many fields, including astrophysics, bioinformatics, computer science, nanotechnology, nuclear scien...JCI table of contents: September 21, 2006
...se getting past the cells that act as a barrier to entry into the brain. Conversely, a mixture of the soluble factors produced by T. b. gambiense, which includes brucipain, helped a related parasite T. b. brucei that normally cannot get past these barrier cells cross the barrier. Further analysis showed th...Plants give up answers in the war on bacteria
...atine, to force the pores back open. For bacteria, entry is crucial to causing disease and probably survival. They could die if left lingering on the surface. Animal-based bacteria do not produce coronatine. "Now that we know a key step in bacteria's attack, we have something we can learn to interfere wi...Research shows how ultrasound can deliver therapeutic molecules into living cells
...rotective outer membranes of living cells to allow entry of drugs and other therapeutic molecules and how ... closed by the cells in a matter of minutes, allow entry of therapeutic molecules as large as 50 nanometers in diameter larger than most proteins and simila...Viruses can jump between primates and humans, researchers warn
...kept as pets. Each of these settings could provide entry points for monkey viruses like SFV to infect humans, or for human viruses like measles to jump to monkeys. Either population can be at risk from these transmissions: measles can devastate monkey populations, while some monkey viruses can also harm pe...University of California, San Diego-led team discovers how we detect sour taste
...t our findings could be an exciting and unexpected entry into understanding these devastating kidney disorders," he said....ACS news service Weekly PressPac -- August 16, 2006
...al compounds that interfere with the measles virus entry into cells and which may be effective when taken by mouth. To date, no drug is available for the treatment of measles and the control of local outbreaks. One of the new compounds appears especially promising, and the scientists are moving ahead with ...Virus has 'catastrophic' affect on red squirrels, research shows
...d is to target grey squirrel control at the narrow entry points and corridors to England's 16 designated re...the disease could be targeted locally along likely entry points. In this second study, the team describes how it is applying computer technology to develop......nt part of AMD, to show that preventing macrophage entry into the eye encouraged new vessel formation, whereas direct injection of macrophages significantly inhibited this process. Age-related macular degeneration (AMD) is the leading cause of blindness in people over 50 y of age in at least three contin...