MatBase -- A new transcription factor knowledge base released by Genomatix
....In contrast to other available TF databases, each entry in MatBase is thoroughly tested for quality and usability for functional analysis of DNA regulatory regions. "We have developed our in-house TF database now for more than a decade", says Kornelie Frech, GenomatixHead of Biological Databases." Quali...Movie spies on malaria parasite's sneaky behavior
...rriors who hid inside a giant hollow horse to gain entry to Troy, the malaria parasites wrap themselves in a structure made of liver cell membrane. This membrane cloak enables them to sneak past immune cell sentinels and return to the bloodstream. The malaria parasite, Plasmodium falciparum, has a comple...Smooth sailing: 'Cruise Ship Virus' tackled by UH, Baylor College of Medicine
...making a system work at a doctor's office or at an entry point to the cruise ship." The ease with which Norwalk is spread makes it important to the field of biodefense, as well, which is a key point with the RCE helping to fund this research. According to Ruchhoeft, while the center is certainly inter...Figuring out function from bacteria's bewildering forms
...lasm" in between. Experiments demonstrated initial entry of organic phosphate across the entire cell surface, including the stalk. Once across the outer membrane, the organic phosphate is converted to inorganic phosphate and diffuses from the stalk toward the cell body periplasm. When the phosphate reaches...Eleven million Euros for Endotrack
...ed endocytosis (a process in which substances gain entry into cells without passing through the cell membrane). During endocytosis the cell takes in molecules (cargo) binding to components of the outer membrane of the cell: the cell membrane invaginates, enclosing the cargo and forming an intracellular ves...Researchers discover inhibitor of infection by HPV
...his process by attaching to HPV and preventing its entry into cells. Christopher Buck, lead author of the study and post-doctoral fellow at the National Cancer Institute, searched for candidate inhibitory compounds by looking for substances that were structurally similar to a key cell surface component i...HIV infection requires B cells with special protein, University of Pittsburgh researchers report
...dies of these cells indicate DC-SIGN is a point of entry for HIV and necessary for T cell infection. B cells were isolated from blood samples obtained in 33 healthy subjects and 20 adult patients with HIV from the Multicenter AIDS Cohort Study (MACS), 10 of whom had suppressed virus due to antiretroviral...The protein that makes you mad
...wall. The cells containing the PrP c could be the entry gate but what cells are they? Are the same in different animal species? Nobody knows. Answering these questions has been the aim of this thesis and, in order to achieve this objective, we carried out a "sweep" along the digestive tract of rats, prim...How IVF could be causing genetic errors in embryos
...tem) and the hepatitis C virus binds to it to gain entry to cells. H19 a developmentally regulated gene, thought to be a tumour suppressor and associated with Beckwith Wiedeman syndrome. Slc38a4 plays a role in amino acid transport to cells. Copg2 plays a role in transport of proteins within cells and...Sandia tool speeds up environmental cleanup, reopening of contaminated facilities
...rts, subways Government buildings Ports of entry Water utilities Gas and electric utilities Chemical plants Other critical infrastructure facilities Cost, efficiency savings could reach into multi-millions of dollars The cost to shut down public facilities, plants, or busin...Gene first linked to rare disease may trigger skin cancer, other tumors
...ia. That modification bars the oncogenic protein's entry into the cell nucleus, the central command center and storehouse for DNA, where it would otherwise drive the uncontrolled increase in cell numbers characteristic of tumor growth. The researchers first showed that mice lacking CYLD were highly sensiti...Research uncovers signaling pathways related to brain-immune system links
...eservoir for HIV, a strategy that denies the virus entry into those immune cells may be important in combating HIV infection. Dr. Douglas showed in 2001 that another NK-1R antagonist blocked HIV replication within macrophages in cell culture. The hope is that aprepitant may show a similar protective effect...Fox Chase study sheds light on cancer susceptibility and disease involving bone-marrow failure
...hat depends on a sequence called internal ribosome entry site (IRES). This particular sequence occurs in only some of the messenger RNAs that translate the DNA code into proteins. "One of these proteins with decreased levels is governed by a gene, p27, that normally works to suppress tumors," Ruggero poin...Selectively blocking inflammatory signals may protect mice from MS
...ses at the University of Chicago, "but it can gain entry after an inflammatory flare-up. We previously showed how it harmed oligodendrocytes. Here we confirm its direct harmful effects on those cells and demonstrate one way of protecting them." The researchers produced a series of transgenic mice. In on...Mutant mice show key autism traits
...escribed are intriguing and represent an important entry point to understanding the role of Pten in postmitotic neurons of the hippocampus and cortex as well as providing new insight into the molecular correlates mediating social- and anxiety-related behaviors in the postnatal CNS."...Scientists design potent anthrax toxin inhibitor
...ptor-binding protein used by anthrax toxin to gain entry into a host cell. The protein-spiked fatty bubble,...ound tightly to PA, the subsequent steps of enzyme entry cannot occur and the toxin is effectively neutralized. The investigators tested the anthrax inhibit...Targeted drug delivery now possible with 'pHLIP' peptide
...ular pH of 5.5 to 6.5. The study shows that pHLIP entry into the cell membrane and the translocation of molecules into cells are not mediated by the usual entry pathways -- endocytosis, interactions with cell receptors, or by formation of pores in cell membrane...Studies explore the many complex linkages between smoking and cancer
...pared to those who had never smoked at the time of entry into the study. Former smokers had a 50 percent (1.48) higher risk than those who had never smoked. This was after taking into account other possible risk factors, such as age, number of children, menopausal status, oral contraceptive use, and hormon...Emerging disease risks prompt scientists to call
...udies say passive detection of disease at ports of entry is an increasingly dangerous strategy as the volum...uch as quarantine facilities, markets and ports of entry can also result in the transmission of agents between individuals and species, with rapid subsequent...Researchers discover botulism toxin's insidious route into nerve cells
...protein that the toxin recognized and used to gain entry into the cell was unknown. "We decided to study the entry route used by these toxins first," said Chapman. Using cultured neurons and mouse diaphragms as mode...