Tag: "entry" at biology news

Scientists reveal how deadly toxin hijacks cells

... botox latches onto a protein known as SV2 to gain entry into neurons. "Our work shows that botox is reall...developing anti-toxin reagents which may block the entry of toxins into cells." The botulinum toxins, of which there are seven types, are made by a bacterium...

Tips from the journals of the American Society for Microbiology

...erent blocks in a specific order with the order of entry resulting from theoretical or logical importance. This approach was applied to Cryptococcus neoformans and Bacillus anthracis and results showed the method to be useful in determining the relative contributions of virulence factors in pathogenesis. ...

Stopping smad

...sizes that, "we are excited now that we have a new entry point to the bigger question of how BMP signals can be downregulated in various physiological contexts". ...

Clock molecule's sensitivity to lithium sheds light on bipolar disorder

...d have the potential of providing another point of entry into the circadian pathway. Noting that Rev-erb is present in metabolically active tissues, Lazar and his team at the Institute for Diabetes, Obesity, and Metabolism are also interested in the relationship between the control of the circadian clock...

How sperm crack the whip

...lity and design new contraceptives to thwart sperm entry into the egg. What's more, they said, the exquisitely delicate analytical technique they used to eavesdrop on the electrical currents inside the squirming sperm cell could literally open a new window into its largely mysterious inner workings. Howar...

UCSD study finds anthrax toxins also harmful to fruit flies

...use fruit flies lack components required for toxin entry into cells, they cannot actually contract the anthrax disease. However, the study finds that fruit flies can be used to test the effects of a single virulence factor, such as the LF or EF toxins, on signaling pathways shared by flies and humans. Guic...

Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal

...bidden city", in which the immune system is denied entry as its activity is perceived as a possible threat to the complex and dynamic nerve cell networks. Furthermore, immune cells that recognize the brain's own components("autoimmune" cells) are viewed as a real danger as they can induce autoimmune diseas...

Scientists identify molecular structure of key viral protein

...ning novel anti-viral agents and understanding the entry mechanisms of other viruses. Knowing the structure...rom the initial metastable state to the post-virus entry state that drives the fusion of viral and cellular membranes, permitting entry of the viral genome i...

Interim long-term follow-up data show AMG 531 increases platelets in patients with ITP

...ht patients had undergone splenectomy before study entry and eight were receiving concurrent corticosteroids for ITP. Overall, 47 percent of patients (n=16) had a durable platelet response, defined as platelet response at six or more weeks between weeks 18 through 25. Of the eight patients on concurrent ...

Purdue biologists clarify how a cellular 'spacecraft' opens its airlock

...ey use a cell's energy to permit or deny materials entry into the interior of the cell from the outside wor...rlocks, which ensure that only the astronauts gain entry and no air is lost. Where spacecraft have metal walls, cells have membranes that surround their inne...

New insights into protein synthesis and Hepatitis C infections

...drawing the mRNA's 5'-end cap through the ribosome entry site and towards the exit, eIF3 ensures the mRNA i...itis C virus (HVC), known as the internal ribosome entry site (IRES), and pin it to the exit site of the 40S ribosome subunit. The IRES leaves through the le...

Give an ant a nice place to stay and it might stick around

...tment of Agriculture from 1927 to 1985 at ports of entry around the country. Ward and Suarez spent years identifying 232 different species from 394 samples. Then they teamed with David Holway, a professor of biology at UC San Diego, to analyze their discoveries....

Plants have a double line of defence

... a plant cell, the peroxisomes are led over to the entry site by the attached PEN2 protein. One or more sug...n the surface of the plant, or a lack of molecular entry sites for pathogens. But the researchers in Cologne have now shown that active immune responses make...

Innovative research set to push boundaries of cancer care

...Center have developed an agent that not only gains entry into the brain, but also targets topoisomerase II ...roteins efflux, hypothesizing that this will allow entry into both the blood-brain barrier and glioma tumor cells. Out of 400 DNA binding agents, they selec...

Mechanism of new 'sudden-death' arrhythmia detailed

...most important of these ions is calcium, since its entry into a cell causes the contraction of the cell. However, before the next heartbeat, the calcium needs to be pumped out of the cell. We found that the ankyrin-B complex acts as a safety valve that maintains the appropriate calcium balance." However, f...

Winners of 2005 AAAS Science Journalism Awards

...roducer for news at USA Today.com, said Grossman's entry is "richly interactive, with important research that makes learning fun." Grossman, a AAAS prize winner for the second time, said he chose Madagascar as a venue for his reporting after previous trips to Antarctica and Greenland. "I decided I wanted ...

Collaborations yield new discoveries in psychiatric genetics

...nd where they are supposed to, there is a point of entry for therapeutics," Firestein said. "While we can't make the therapeutics right now, we may have established some targets."...

e-Science records Roman finds

...ese records are digitised the following winter for entry into the York-based Integrated Archaeological Database (IADB), which is held on a server in Reading. The Silchester VRE project has three main aims. The first is to streamline this data gathering process, so saving time spent later on digitising re...

Protein structure key for AIDS, cell function

...nteraction between the AIDS virus and its point of entry into cells -- a protein receptor called CD4. By looking at CD38's 3-D structure, the Cornell researchers identified a peptide, an organic compound composed of amino acids, that they believe may play a role in interrupting the interface between CD4 an...

Researchers discover how compounds prevent viruses from entering cells

...iscovered that defensins block the influenza virus entry into cells by preventing the fusion of viral and cell membranes. Specifically, the researchers studied the antiviral effects of two different classes of defensins, theta-defensin and beta defensin. Membranes--the outer covering of cells and of man...

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(Date:10/16/2014)... human body. Battles are won, lost or sometimes ... stalemate—known as tumor dormancy—can last up to 25 ... is poorly understood. , A new computational ... a Professor of Chemistry at Princeton University, may ... the switch to a malignant state. Published today ...
(Date:10/16/2014)... Washington land managers have a new synthesis of recent ... mixed-conifer (MMC) forests in the two states. , ... Eastern Oregon and Washington: A Synthesis of the Relevant ... general technical report published by the U.S. Forest Service,s ... a request from managers for a synthesis of the ...
(Date:10/16/2014)... can be cultivated efficiently, they are anything but ... by monoculture cultivation is becoming increasingly evident. Despite ... form and are regarded as the sole possibility ... quite wrongfully, finds Bernhard Schmid, an ecology professor ... novel form of agriculture and forestry. After all, ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2New report synthesizes best available science on management of moist mixed-conifer forests 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
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