Tag: "enzyme" at biology news
DNA movement linked to formation of antibody genes
...secondary structure of the Hermes transposase (the enzyme
that mediates Hermes element transposition) with the RAG1 recombinase (the enzyme
that mediates V(D)J recombination) and the transposases of some retroviruses shows clear similaritie...
Healthy cleavage: How statins protect against Alzheimer disease
...myloidogenic ("amyloid generating") cleavage by an enzyme
called beta-secretase yields "sticky" (A b ) pepti...eagues focused on a molecule called ROCK, a kinase enzyme
that had recently been implicated in APP processing. Working in mouse neuroblastoma cells, they conf...
UCSD medical researchers discover molecular pathway that turns a juvenile heart into an adult heart
...protein called ASF/SF2 as a regulator of a calcium enzyme
responsible for heart contraction and tissue growth. Mice born with mutated or absent ASF/SF2 had shortened contractive fiber that appeared locked in a contracted state, leading to sudden death. When ASF/SF2 was normal, heart development progressed ...
Enzyme allows B cells to resist death, leading to leukemia
... of expression and altered cellular location of an enzyme
in B cells known as Lyn, contributes to the develo...xpressed in CLL cells and an unusual amount of the enzyme
was found in the cell cytosol. In addition, the enzyme
was constantly active compared with levels of...
Clam embryo study shows pollutant mixture adversely affects nerve cell development
...esulted in increased production of a subunit of an enzyme
called protein kinase A (PKA), which previous rese...during development," she says. Alterations of this enzyme
may affect neural development and neural connections by activating or inactivating other proteins. ...
EB and IUPS - Where cures of tomorrow can be seen in the science of today
...isease; radical enzymes, and directed evolution of enzyme
function; proteases in infectious diseases, neoplasia and angiogenesis; protein inhibitors in drug design; and gene and protein networks and medicine. Eight award lectures by leading experts include topics such as orphan nuclear receptors, lipid-prot...
Combination therapy boosts effectiveness of telomere-directed cancer cell death
...erase inhibition is combined with inhibition of an enzyme
called tankyrase 1 that is involved in making telomeres accessible to telomerase. The researchers found that both tankyrase 1 activity and telomere shortening decrease the effects of telomerase inhibitors. Importantly, tankyrase inhibition enhanced t...
A new New Year's reason to work out: Exercise improves three measures of heart protection
...y measure. Tissue plasminogen activator (TPA), an enzyme
made by the body that breaks up blood clots, was higher in physically fit women compared to unfit women. Plasminogen activator inhibitor-1, a blood substance that inhibits TPA, was lower in physically fit women. And, a marker that indicates blood c...
The Cochrane Library Newsletter, 2005, Issue 1
...ing the active site on acetylcholinesterase, a key enzyme
in the nervous system. In theory oximes should help as they can remove this block. The Cochrane authors, however, found that very little research has been done to see whether oximes are effective. What work has been carried out produced...
Lack of enzyme turns fat cells into fat burners
...the effect ACC2 has on mice. Mice bred to lack the enzyme
can eat a high fat, high carbohydrate diet without...intenance," said Wakil. "ACC2 is potentially a key enzyme
in the regulation of weight, obesity, and related problems." Wakil and his colleagues studied the ox...
Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
.... The researchers' findings also suggest that this enzyme
system may be useful in developing preventative therapies against skin cancer. Ultraviolet light is a known source of damage to our DNA, but under normal conditions humans and other mammals are capable of removing UV-induced DNA damage by a DNA repai...
Novel approach yields predictions validated by experiments
...iferation of cells in cancer, or the absence of an enzyme
that results in an inherited metabolic disease, Voit explained. Another application for mathematical models is drug design. Researchers could use models to find optimal points in a metabolic pathway for drug intervention that would achieve desired t...
New puzzle-piece shows how growth hormones work in plants
.... Because the CPD gene orders the production of an enzyme
needed for BR synthesis, this suppression stops the production of BR conferring a feedback regulation of BR production. When the BR steroid level is high, BZR1 is activated and BR synthesis is reduced. When the level is low, the synthesis is high. Th...
Pro-inflammatory enzyme linked to diabetes; Immune system's macrophages may be key to treatment
that initiates inflammation has been directly link...addition, the team suggests that inhibition of the enzyme
in the immune system's macrophages may be a new diabetes therapy. Published in the February 2005 iss...
VCU research shows erectile dysfunction drug reduces death of heart cells in heart attack model
...nd the presence of phosphodiesterase-5 (PDE-5), an enzyme
responsible for the destruction of the cGMP molecule, in the heart cells. The cGMP is an intracellular messenger molecule that plays an important role in the dilation of arteries in the body. Sildenafil is able to preserve cGMP, and therefore dilatio...
Transgenic plants remove more selenium from polluted soil than wild plants, new tests show
...stard plants was engineered to produce more of the enzyme
adenosine triphosphate sulfurylase (APS). The enzyme
is key to the plant's ability to convert selenate into a non-toxic form of selenium, allowing the pl...
Increased risk of osteoporosis associated with gene that one in five people have
... online. The gene, named CYP1A1, makes an abundant enzyme
that detoxifies foreign substances and also breaks... this particular variation of the gene produces an enzyme
that breaks down estrogen faster than usual, leading to low serum estrogen levels and high levels of...
Progress toward a more targeted treatment of Alzheimer's disease
... in this process is played by γ-secretase, an enzyme
that cuts proteins in a particular place. Sometimes the γ-secretase cleavage goes wrong, causing the creation of a by-product that sticks together and precipitates - thus forming the plaque. In their quest for new medicines, scientists are inves...
Researchers at UT Southwestern discover new function for old enzyme
...outhwestern Medical Center have discovered that an enzyme
important in the production of energy also protect...olecular biology, has shown a new function for the enzyme
keeping the mitochondrial genome intact. The study is available online and in the Feb. 4 edition o...
Pro-inflammatory protein contributes to Crohn's disease according to UCSD School of Medicine study
... Karin said, "only under certain circumstances, an enzyme
called IL1 converting enzyme
(ICE) is activated, the IL-1 precursors, whose synthesis is stimulated by NF-kB, are cleaved and the...
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