Gene therapy for Parkinson's disease moves forward in animals
...r treatment, the animals receiving the therapeutic enzyme mixture show complete recovery in their paws. Researchers say not only did the rats recover substantial degrees of function in their impaired forelimbs, continuous levels of L-dopa were being produced in their brains, blocking side effects....New stem cell source could boost bone marrow success
...re sutured closed and suspended in collagenase, an enzyme that breaks down the Wharton's Jelly around the vessels to release the cells inside. The HUCPV cells were then isolated and cultivated in vitro. Many parents already freeze the cord blood cells containing hematopoietic stem cells, but U of T profess...JCI Table of Contents, March 1, 2005
...sease, it blocked tissue damage, normalized kidney enzyme levels, inhibited degradation of the proximal tubule, increased protective enzymes, and suppressed cell death. The work will be of interest in the field of kidney diseases and therapeutics. TITLE: Endocytic delivery of lipocalin-siderophore-iron ...Tufts-NEMC researchers identify enzyme that activates cancer cell growth and invasion
...Medical Center have identified a long-sought-after enzyme that interacts with a specific protease-activated ...n the inside surface of the cell downstream of the enzyme and receptor. Their study appears in the February 11 edition of the journal Cell. PARs are a unique ...HHMI professor, 138 undergraduates identify essential genes in eye formation
...n Banerjee's flies is the presence of flippase, an enzyme genetically engineered into the flies that is expressed only in the eye. Through a series of five crosses or matings of successive generations of flies, the students created flies with homozygous lethal mutations in the eye, independently marked by ...Diabetes' link to obesity broken in mice
...scientists gave a drug that inhibited an important enzyme in the processes that let muscle cells make energy from fat. PPAR-alpha normally activates this enzyme as part of its efforts to accelerate fat metabolism, and blocking it essentially tricked the cell in...Intervention cuts nerve damage, boosts life span
...to flow back across the membrane through a special enzyme that harnesses the energy released in the form of ATP molecules. However, so-called mitochondrial uncoupling proteins (UCPs) allow some of the protons to leak into the matrix, thus disrupting the electrochemical gradient and partially "uncoupling" pr...Could schizophrenia arise from a single defect?
... gene produces a protein that is a component of an enzyme called g-secretase, which plays a role in regulating many processes in the developing brain. The researchers found that, as a result of this lower level of Aph-1b protein, g-secretase showed reduced activity in the brains of the susceptible rats. Wha...Mechanical tension helps shape lung development
...by modulating the activity of a cellular signaling enzyme called Rho. Rho facilitates a chemical reaction that causes contraction of fibers in the cytoskeleton, increasing tension in the cell and in its connections to the matrix. Ingber's team put lungs from embryonic mice in culture and exposed them to var...Enzyme shown to help protect genomic stability
...earchers at The Wistar Institute has shown that an enzyme known as Ubp10 plays a vital role in protecting th...from potential destabilizing molecular events. The enzyme helps to keep the genome structurally closed, unavailable for transcription and possibly protected f...Purdue proves concept of using nano-materials for drug discovery
...membranes." Researchers tested the devices with an enzyme that produces a blue color when combined with a liquid that contains molecules small enough to easily pass through the pores. The enzyme, which is a protein, was placed inside the vessels - on the inner surface of the alumina membranes - and the liqu...ASBMB Schering-Plough Award lecture to focus on histone modifications in transcription
... focus specifically on Dr. Strahl's research on an enzyme called Rad6, which is responsible for adding ubiqu...red that Rad6 is associated with polymerase II, an enzyme complex responsible for producing mRNA from DNA. This interaction is mediated by the Paf1 transcript...JCI table of contents March 1, 2005
..., have abnormal artery function. Kallikrein is an enzyme involved in vascular physiology. Subjects carrying the kallikrein mutation may be at increased risk for progression of vascular diseases. In an accompanying commentary, Oscar Carretero states, "these findings raise the intriguing possibility that de...Duke researchers uncover genetic link to kidney damage after heart surgery
...ric oxide synthase 849T and angiotensin converting enzyme deletion allele had a 162.5 percent increase in creatinine in the blood. This translates into a 60 percent reduction in the kidney's filtering ability, a rate more than twice as high as the study population as a whole. "If this vulnerability is born...Research may provide ways to inhibit cancer's ability to resist treatments
...rch Institute in Toronto have discovered how a key enzyme involved in repairing DNA is put together and how ...ree dimensions--polynucleotide kinase (PNK), a key enzyme involved in a cell's ability to repair single-strand and double-strand breaks in DNA. "This gives us...Biochemists report discovery of structure of major piece of telomerase; implications for cancer
...nal structure of a major domain of telomerase, the enzyme that helps maintain telomeres small pieces of DNA...rotein requires the RNA component to function. The enzyme is unique because it has its own internal piece of RNA that is used to copy the DNA, but this 'templ...Genetic therapy reverses nervous system damage in animal model of inherited human disease
... are born with a faulty version of the gene for an enzyme called lysosomal alpha-mannosidase or LAMAN. "Sh...strong promoters that could increase the amount of enzyme that comes from corrected cells." Although encouraged by their findings, the researchers note that ...New tumor-suppressor gene discovered
...e a protein that forms a complex with a kinase--an enzyme that catalyzes genetic activity--so we wondered if the protein product of our mats gene also could function in this way." Lai was particularly intrigued by the possibility that the protein product of the mats gene could partner with the kinase produ...Enriched environment delays onset of Alzheimer's in mice
... Mice from enriched settings also had more of an enzyme that breaks down amyloid as well as increased acti...tect nerve cells. One of them was the gene for an enzyme that degrades beta-amyloid called neprilysin, which was at significantly higher levels in mice from ...New class of tuberculosis-fighting antibiotics suggested by biochemical-pathway study
...acterized the pathway and showed that an important enzyme in it is a key target for anti-TB agents. The path... "We discovered that if you inhibit the very first enzyme in the chain, you inhibit everything else downstream and eventually the bacteria die," he explains. ...