Screening approach leads to discovery of gene linked to breast cancer
...of 354 human kinases and injected each into normal epithelial cells to see if any mimicked PI3K's ability to transform them into cancer cells. They found five that did. To narrow this field, investigators conducted a second group of screening procedures. Using a variety of genome-scale approaches, they sought...Staphylococcus aureus hides out in cells
...ncover what S. aureus (6850) did inside human lung epithelial cells (A549) using an in vitro model. They found t...y, production of toxins potentially lethal for the epithelial cells becomes strictly controlled to limit cellular damage. Mechanisms that helped the bacteria to s...Mucosal-surface immune function discoveries could boost vaccine research
...dbreaking research at Weill Cornell shows that the epithelial cells that line these mucosal surfaces help guide ...wholly new finding, since most biologists think of epithelial cells as a barrier cell -- not as a highly active player in immune function," explains senior resear...Surprising origin of cell's internal highways
...ing ("plus") ends of microtubules in human retinal epithelial cells with a fluorescent molecule, videotaped their growth and carefully followed the tracks back to their origin. "We show that not only the centrosome, but the Golgi also makes microtubules," Kaverina said. "And unlike centrosomal microtubules, ...UCF professor finds bacterial pathogen may be key to understanding cancer development
... We found that Listeria actually provokes human epithelial cells (cells lining the small intestine) into inge...g bacteria, Ireton said. When Listeria contacts an epithelial cell, the bacterium causes changes in the cells cytoskeleton that allow the cell to swallow up the b...Small molecules may explain psoriasis
...ed in psoriasis and is only expressed by the skins epithelial cells, keratinocytes. No one has previously investigated whether this quite recently discovered group of molecules might be significant in inflammatory diseases. Psoriasis and atopic eczema are the most common chronic inflammatory skin diseases. D...A new method of adult stem cell growth efficacious in treatment of disorders of the cornea
...ransplant in rabbits, which previously have had an epithelial corneal lesion induced, causing loss of corneal transparency. This is a pathology that does not respond to a corneal transplant nor to other conventional treatment. The procedure used by Dr Fernndez Hortelano involved obtaining this type of cell c...JCI table of contents: July 19, 2007
...is organism was able to enter the gastrointestinal epithelial cells lining the gut of both Muc1-deficient and Mu... was exclusively due to Muc1 on the surface of gut epithelial cells. This is believed to be the first study in animals to demonstrate that cell surface mucins are...Mucins stand guard against gut infections
...is organism was able to enter the gastrointestinal epithelial cells lining the gut of both Muc1-deficient and Mu... was exclusively due to Muc1 on the surface of gut epithelial cells. This is believed to be the first study in animals to demonstrate that cell surface mucins are...UB scientist discovers novel iron-copper alliance
...n/copper-deficient rodents and cultured intestinal epithelial cells. This project is intended to test the overall hypothesis that increased copper transport during iron-deficiency is critical to enhance certain aspects of intestinal iron absorption, said Collins. Iron or copper deficiency causes anemia, and a...MIT model could predict cells' response to drugs
...evels in five major signaling pathways after colon epithelial cells were exposed to a variety of environmental s...ly predict what would happen to two other types of epithelial cells when exposed to the same stimuli. "Cells appear to be adding up information across multiple ...Research shows NPD1 protects a key component of vision
... (NPD1) protects against damage to retinal pigment epithelial (RPE) cells and identifies an important trigger fo...are entitled Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling and Photoreceptor outer segment phagocytosis atten......loped a cell-free system using extracts from human epithelial cells that were engineered to over-express specific miRNA pathway components. They introduced exogenous let-7 miRNAs and monitored its effects on the translation of luciferase reporter mRNA. The researchers found that let-7 miRNAs recruited miRNP......s wielded with even gentle force tear holes in the epithelial cells that line the gums and tongue, causing a mom...pe of brush might strongly influence the extent of epithelial cell-wounding and subsequent liberation of factors that promote gum health, Dr. McNeil says. Inte...