Study examines role of EGFR gene mutations in lung cancer development
...om many of the lung cancer patients and from other epithelial cancer tissues. In lung cancer patients, mutations in the TK domain of the EGFR gene were more common in never smokers than in smokers (51% versus 10%), adenocarcinomas versus other types of lung cancer (40% versus 3%), in patients of East Asian ance...Secrets of the cilia: Kidney disease and blindness share common genetic defect
...ulin and RGPR, is expressed in the cilia of kidney epithelial cells, and also in the connecting cilia of photoreceptors," Hildebrandt explains. "In other words, defects in cilia tie together the disease phenotypes of the kidney and the eyes." Work by other researchers suggests additional connections. "In a dis...JCI table of contents April 1, 2005
...K1 (thought to be a potential cause of ADPKD) have epithelial cells that proliferate to form cysts. The cells a...ding cyst formation and function of PKD1 in kidney epithelial cells. These findings will help in the search for drugs for prevention of renal failure of ADPKD pat...APS announces 2005 Young Investigators Awards
...ndividual with outstanding promise in the field of epithelial and renal physiology and will be given on Dr. Ma's behalf to University of North Texas Health Sciences Center. His research focuses on physiological function and regulating mechanisms of ion channels in kidney cells. Dr. Ma also studies pathological...The Bacteria's guide to survival
...mbranes. The study examined gene activity in human epithelial cells infected with Neisseria gonorrhoeae , the bacteria responsible for the sexually transmitted disease gonorrhea. By comparing cells infected with normal N. gonorrhoeae to those infected with a mutant strain with defective pili, the researcher...Protein protects kidneys from damage caused by chronic renal disease and injury
...When BMP7 binds to the type 1 receptor on a kidney epithelial cell, it triggers signaling proteins called Smads,...we found that KCP is secreted primarily by tubular epithelial cells in the kidney. When it attaches to BMP7, it increases the stability between BMP7 and the cell'...BRCA1 causes ovarian cancer through indirect, biochemical route
...e tumor cells were analyzed, they were found to be epithelial cells very similar to those found in human ovarian...normally give off a chemical signal that stops the epithelial cells from growing out of control. When that chemical signal disappears or is muted by a mutation in...U of T researchers map role of Epstein-Barr virus in cancer
...ell cancers like Burkitt's lymphoma as well as the epithelial cell cancer, nasopharyngeal carcinoma. EBNA1 is a protein coded in the Epstein-Barr virus and suspected to play a role in the development of cancer," says Lori Frappier, professor in medical genetics and microbiology at U of T and senior author of a ...Growth factor in baby formula could reduce NEC, most devastating GI disease in preemies
...pared to the NEC group. Cleaved caspase-3 positive epithelial cells, indicating cells undergoing apoptosis, were...ping an in vitro system, using cultured intestinal epithelial cells, to study these signaling cascades." Research was supported by an American Physiological Soci...SERPINE2 identified as novel candidate gene for COPD, especially with smoking
... cell-associated pattern within bronchiolar airway epithelial cells and in an extracellular matrix-associated pattern in the vascular adventitia. Immunohistochemistry in human lungs demonstrated an analogous staining pattern. "Our studies revealed cell-specific and developmentally-regulated expression of SERPIN...Thumbnail sampler of 10 diverse physiology papers from IUPS 2005
...ogy 349.3. Featured topic 340: "Molecular basis of epithelial disease." Cystic fibrosis is the most common fatal genetic disease among Caucasians, with about 30,000 CF patients in North America. Researchers tested the notion that introducing a fragment of mutant CFTR (cystic fibrosis transmembrane conductance r...Chronic inflammation caused by too little stomach acid leads to gastric cancer
...ncers are adenocarcinomas, meaning they develop in epithelial cells lining the stomach. The American Cancer Soci...ng pre-cancerous physical and molecular changes in epithelial cells lining the stomach wall. Now, she has a new research partner a line of genetically engineered...A little stress gives beneficial oomph! to immune system
... challenges or wounds involve on the skin or other epithelial linings of the body," Dhabhar said. "If nothing happens immunologically following stress the skin isn't cut or wounded in some other way activated leukocytes usually return to their resting position in a few hours." Some of the mice in the study we...Penn researchers determine structure of binding site of colon-cancer drug and its protein target
...ign," says Ferguson. As is characteristic of many epithelial cancers such as cancers of the head and neck, bre...ucture, treatments for colorectal cancer and other epithelial cancers will be expanded, thereby contributing to the creation of future generations of improved can...Blocking COX-1 slows tumor growth in mice
...inding, that COX-1 inhibition slowed the growth of epithelial ovarian tumors in a mouse model of the disease, is...block both COX enzymes, might improve treatment of epithelial ovarian cancer. The study, posted Sunday on the Web site of the journal Cancer Research, was led by ...Cigarette smoke exacerbates alcohol's effects on defense against Streptococcus pneumoniae
... drug that decreases binding of S. pneumoniae to epithelial cells, and treatment with an agent that stimulates ciliary beating....B cells are required for development of epithelial cancer associated with chronic inflammation
...l B cell activation is an essential step for early epithelial neoplastic development, and B cell-derived soluble mediators are necessary for establishing chronic inflammatory states that potentiate cancer development," explains Dr. Coussens. "Pharmacological interventions attenuating B cell activation or blocki...Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
...). Gamma-delta T cells migrate from the thymus to epithelial tissues such as skin and the linings of the lung. While their precise role remains poorly understood, they perform vital protective functions. Certain lung infections easily cleared from normal laboratory mice are a death sentence for those lacking......od lymphoid leukemias and lymphomas in addition to epithelial tumors later in life. Studies have also indicated that individuals who carry one mutated copy of the ATM gene (i.e., heterozygous mutation carriers) may have a higher risk of breast cancer and perhaps other cancers, but the precise risk is uncertain.......g genes to cells' genomes, it does not target lung epithelial cells. Ebola binds strongly to these cells, so Gary Kobinger at the University of Pennsylvania in Philadelphia tried adding a surface protein from Ebola to HIV. Initial tests on mice showed the hybrid virus was very efficient: the gene it carried was...