Discovery offers promising lead in prostate cancer diagnosis
...ogene. Using laser capture microdissected prostate epithelial cells from malignant and benign prostate tissues and GeneChips, researchers identified ERG as the first proto-oncogene that is commonly overexpressed in early-phase prostate cancer. The cancer-causing genes known as oncogenes and tumor suppressor ge...Mass production of human papillomavirus could lead to gains against cervical cancer
...e cycle, the virus lurks in undifferentiated basal epithelial (skin) cells, said Ahlquist. Once there, it remain...ts visibility to the immune system. Only after the epithelial cells begin differentiating does the virus emerge as distinct, infective viral particles, called vir...Study: Harmless virus kills some cancers
... In this study, the team first used HPV infected epithelial cells and normal human epithelial cells, which are natural hosts for both AAV2 and HPV. In cultures infected with both AAV2 and HPV, t...Viagra shows potential vasopressin-independent cGMP signaling in certain diabetes
...d "Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodies...ading to AQP2 appearance on the plasma membrane of epithelial cells," the paper said. Brown added later that there "are many diseases where there are problems in ...Scripps research scientists discover new key to pulmonary edema in respiratory distress syndrome
... the blood it is supplying with oxygen--a layer of epithelial cells lining the alveoli and a layer of endothelia...onary edema to arise by causing a breakdown of the epithelial barrier. Breakdown of the Tight Junctions The work started as a collaboration between Rosen and ...JCI table of contents July 1, 2005
...ll niche of its own. TITLE: Restoration of tubular epithelial cells during repair of the post ischemic kidney is independent of bone marrow stem cells AUTHOR CONTACT: Jeremy Duffield Harvard Institutes of Medicine, Boston, MA USA Phone: 617-525-5914; Fax: 617-525-5830; E-mail: jduffield@rics.bwh.harvard.edu V...New study finds how cells with damaged DNA alert the immune system
...ant role." The researchers put cultures of ovarian epithelial cells and fibroblasts from mice through a battery of abuse, including heat shock, pH changes, oxygen deprivation and starvation. However, the only type of stress that set off the sequence of events associated with impairment of a cell's genetic mater......stigators thus concentrated on factors controlling epithelial cell organization. Epithelial tissues are speciali...otecting underlying organs. To form these tissues, epithelial cells are tightly interconnected in sheets that line hollow organs and glands, including the breast,...Subtle changes in normal genes implicated in breast cancer
...dy breast cancer tissue, the scientists tested the epithelial and myoepithelial cells that line the breast ducts, and the surrounding cells, known as stoma, including fibroblasts. They found that in all of these cell types, gene expression was altered by epigenetic methylation changes that were not present in n...Researchers find potential Celebrex target in lung cancer
...ers found that PGE2, which is produced normally by epithelial cells but at very high levels in lung cancer and other malignancies, up-regulates the activity of lymphocytes called T-regulatory cells, which suppress immune function, making it even harder for a patient to fight cancer. For the first time, UCLA res...JCI table of contents August 1, 2005
... intestine that either contains PPs or M cells, or epithelial cells alone, in order to study the necessity for M...These data provide the first in vivo evidence that epithelial cells can take up processed antigens and induce a regulated immune response. Title: Mucosal toleran...... of central vision by damaging the retinal pigment epithelial (RPE) cells that lie underneath the macula, the small region of the retina responsible for fine detail at the center of the field of vision. Without RPE cells, the photoreceptors, which are the light detectors, also die. Patients lose the ability to ...Carbon monoxide: Poison gas or anti-inflammatory drug?
...em to dilate and relax. But when it's expressed in epithelial cells in airways, it generates a flood of leukocyt... Hmox enzyme expressed in white blood cells and in epithelial cells lining the grafted trachea. "We did this to determine the source of CO," Pinsky says. "Was it ...Discarded placentas deliver researchers promising cells similar to embryonic stem cells
...results of their studies, these so-called amniotic epithelial cells could in fact be directed to form liver, pan...ers calculate there are about 300 million amniotic epithelial cells that potentially could be expanded to between 10 and 60 billion cells relatively easily. "Prov...Eye on the prize: UH optometry students set record with fellowships
...or her research in molecular mechanisms of corneal epithelial cell death and survival. Established in 1949, the AOF is dedicated to the advancement of optometric education and research, awarding more than 200 fellowships since then. Included among former Ezell Fellows are 21 optometric deans and presidents, ......ar tissues--including skin and other multi-layered epithelial tissues--after the animals reached maturity. The effects of premature aging observed in these p63 deficient mice (image available on request) were hair loss, reduced fitness and body weight, progressive curvature of the spine, and a shortened lifespa...JCI table of contents September 1, 2005
.... The oval cells can become either liver cells or epithelial cells, and are vital for recovery from liver injur...ouple mechanical stimuli to alterations in bladder epithelial membrane traffic. The authors show that ATP plays an important upstream sensory role that signals b...Researchers discover how compounds prevent viruses from entering cells
...lls include leukocytes, a type of immune cell, and epithelial cells, which line the surfaces of many organs and ...ues. In the current study, the researchers studied epithelial cells from the inner surface of the lungs. The researchers discovered that defensins block the infl...Study in Royal Society journal on possiblity of human organ regeneration
... alone (or scaffolds seeded with the subject's own epithelial cells). This development may obviate the use of organ transplants in the future. Also note that, in this treatment, stem cells are not required to be used by the investigator. It has been widely thought previously that only the early mammalian foetus......IAL BARRIER DYSFUNCTION ON THE RUN The intestinal epithelial permeability barrier is compromised in a variety o...ate by which T cell activation leads to intestinal epithelial barrier dysfunction. Diarrhea does not occur in epithelial MLCK knockout mice. Furthermore, the in...