Jefferson scientists identify gene defect leading to abnormal skin development and cancer
...anding of the susceptibility to and development of epithelial cancers such as those of the breast, prostate, skin, lung, ovary and colon, and could predict a person's response to cancer therapy. Further studies may also lead to applications for hair loss treatment....EPA-led group finds same protein that attracts nutrient iron protects lung from particles
... air pollution particle that damages the pulmonary epithelial surface." The paper "Divalent metal transporter-1...eresting finding was that "exposure of respiratory epithelial cells to vanadium decreased both mRNA and expression of IRE. Among multiple metals we have tested (t...Inherited gene change also found in spontaneous tumors
...r beta normally slows the growth of cells known as epithelial cells, and may stimulate the growth of cancerous epithelial cells. (Epithelial cells line the ducts, passages and hollow organs of the body and are the cells in...Shorter colds, milder flu may follow from newly revealed immune mechanism
...sm. Death of infected lung airway lining cells, or epithelial cells, would deprive the virus of its home and pro...ate these signals during an infection, and so make epithelial cells and macrophages more effective to shorten recovery time or lessen symptoms." The ability to de...FSU biologists describe key role of signal-transcribing gene during cell cycle
...rough the "Notch" gene, which regulates a layer of epithelial cells as they replicate and divide. But when Cut garbles those signals the result is uncontrolled cell proliferation, sometimes with dire genetic and health consequences. Results of the study are described in the Oct. 1 edition of the journal Develop...Penn virologist edits comprehensive book on Epstein-Barr virus
...homas), certain forms of T-cell lymphoma, and some epithelial tumors (nasopharyngeal carcinomas and gastric carcinomas). "This exceptional volume represents the first extensive reference guide for the field of EBV research, which is intended to impart to readers a sense of discovery, a discussion of initial an...Study sheds light on signaling mechanism in stem cells, cancer
...ey carried out two studies, one involving cultured epithelial and fibroblasts cells expressing Smoothened, anoth...that no longer could move to the primary cilium in epithelial cells in culture and in zebrafish embryos to see if the protein still functioned. It did not. "Thus,...U-M scientists say fused genes trigger the development of prostate cancer
...s that similar mechanisms may be involved in other epithelial cancers, such as breast, lung and colon." The abno...olid tumor like prostate cancer, which develops in epithelial cells lining the prostate gland. "This is a paradigm shift for all epithelial tumors - such as canc...Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
...cancer which is over-expressed on certain prostate epithelial cells. Experimental results described at ECCO 13 show that these bioconjugates successfully and selectively adhered to PSMA-positive prostate cancer cells, while PSMA-negative cells were not targeted. This prostate cancer targeting was modeled using ...Group proves it's possible to grow new lung alveoli by growing new blood vessels
...li. Oxygen flows from the lungs through ultra-fine epithelial and endothelial tissues into the blood; carbon dioxide diffuses from the blood into the alveoli. In an infant's underdeveloped lungs, the alveoli are larger and fewer and there are fewer developed capillaries. It's a condition that leaves them gaspin...Other highlights in the November 16 JNCI
...tion of premalignant and malignant human bronchial epithelial cells by inhibiting the activation of a cellular pathway called P13K/Akt, which helps cancerous cells survive. Ho-Young Lee, Ph.D., of the University of Texas M. D. Anderson Cancer Center in Houston, and colleagues treated mice with deguelin to deter...Researchers uncover cellular clues to vitamin A resistance in lung cancer
...tidine. In the process of studying human bronchial epithelial cells that were resistant to treatment with retinoic acid, they discovered a previously unknown variant of one of the subtypes of RAR-beta. The variant, called RAR-beta-1', was expressed in normal lung cells and in cells sensitive to retinoic acid, ...Innovative research set to push boundaries of cancer care
... damaging cellular molecules. Radiation can damage epithelial cells and lead to permanent hair loss, among other effects, and certain types of systemic chemotherapy can produce hearing loss and damage to a number of organs, including the heart and kidneys. For those reasons, researchers have been seeking an ag...Tips from the journals of the American Society for Microbiology
...might serve as a source of HPV in the infection of epithelial cells and contribute to their nonsexual spread," say the researchers. "However, additional work is needed to confirm this as a possible mode of HPV transmission." (S. Bodaghi, L.V. Wood, G. Roby, C. Ryder, S.M. Steinberg, Z.M. Zheng. 2005. Could h...Recycled or revamped therapeutics find novel anti-cancer applications
...pidly proliferating cells such as blood cells, the epithelial cells that line the intestine, and skin and hair cells. Proliferating cells crave energy. That hunger may provide two keys to the demise of some cancers, according to Craig B. Thompson, M.D., scientific director of the Abramson Family Cancer Research...USC researchers track down the stem cells that create feathers
...ult bird. Chuong and his USC colleagues identified epithelial stem cells within a chicken-feather follicle by gi...hen incorporated and retained only in the putative epithelial stem cells. They showed that these cells were pluripotent-retaining the ability to differentiate int...Cancer support cells may evolve, fuel tumor growth, study shows
...sed solely on the predominant cancer cell, such as epithelial cells that form the bulk of many tumors including ...Dyke's UNC laboratory. The researchers manipulated epithelial cells the target cell type for prostate cancer causing them to divide at an accelerated rate. Fir...JCI table of contents: January 4, 2006
... alpha-basiccrystallin is overexpressed in mammary epithelial cells and causes dysregulated growth, changes in cell structure, diminished programmed cell death, and the formation of invasive carcinomas that is linked to activation of the ERK/MAPK signaling pathway. These results may facilitate the development o...Breast cancercausing gene predicts shorter survival
... alpha-basiccrystallin is overexpressed in mammary epithelial cells and causes dysregulated growth, changes in cell structure, diminished programmed cell death, and the formation of invasive carcinomas that is linked to activation of the ERK/MAPK signaling pathway. These results may facilitate the development o...... special," Vidal says. "This is the first time the epithelial environment has been shown to play a role in metastasis." The cells that left the fruit fly tumors eventually succumbed to the natural process of programmed cell death and were eliminated. According to Cagan, that was not unexpected. "In a tumor, pr...