Research details how a virus hijacks cell signals to cause infection
...rus entering cells that line the intestine, called epithelial cells. Just how the virus enters those cells has b...elf. However, the CAR remains below the surface of epithelial cells, in a seemingly inaccessible location called the tight junction. In the new study, Drs. Bergel...Scientists find unusual lung-cancer tumor-suppressor gene
...overed gene is unusual because it can alter normal epithelial cells, causing them to change to a more primitive state. Epithelial cells form the skin and line the body's passageways and hollow organs. They are also the source of the most common forms of cancer. The more primitive cell type, known as a mesenchy...Keeping biological tubes in check: New insights into tube size morphogenesis
...phila has provided important general insights into epithelial organ morphogenesis. The fly's tracheal system is a tubular network that functions in respiration by transporting oxygen throughout the insect body. In two separate new studies, researchers have taken advantage of the usefulness of the Drosophila tra...Protein found to control tumor growth in certain breast cancers
...e first time that the protein, which is present in epithelial cells of the intestinal tract and lungs, is linked...nesis. Cells derived from the human breast cancer epithelial cell line MCF-7 the cellular model for estrogen sensitive breast cancer tumors were used to induce...JCI table of contents, February 16, 2006
... vessel wall cells of the lung and in cells called epithelial cells that line the airways. The authors report that it is this pattern of CXCR2 expression on lung cells, and not the presence of CXCR2 on the neutrophils themselves, which is essential for neutrophil recruitment in response to LPS and the resulting...Drawing a crowd: Understanding the signals that bring inflammatory cells into the lung
... vessel wall cells of the lung and in cells called epithelial cells that line the airways. The authors report that it is this pattern of CXCR2 expression on lung cells, and not the presence of CXCR2 on the neutrophils themselves, which is essential for neutrophil recruitment in response to LPS and the resulti...Yale early stage ovarian cancer detection technology licensed by LabCorp
...n of the university's blood testing technology for epithelial ovarian cancer (EOC). In the United States, EOC is the fourth most common cancer in women, and the leading cause of gynecologic cancer death. EOC affects approximately 25,000 women each year, and more than 16,000 will die from the disease. The Yal...JCI table of contents: March 1, 2006
...ter patterning and maturation (differentiation) of epithelial cells. The authors generated mutant mice that did not express the Tbx18 gene and found that the animals developed altered ureter structure and impaired ureter function similar to children born with genetic urinary tract defects. The mice also develop...Bone marrow cells can become functional gut lining cells
...can differentiate into functional gastrointestinal epithelial cells after bone marrow transplantation. Research was from the laboratory of Diane Krause, M.D., professor of Laboratory Medicine and senior author of the study, in collaboration with Marie Egan, M.D., associate professor of pediatrics, respiratory m...HPV subtype associated with squamous cell skin cancers
...ch includes HPV 16, has been associated with other epithelial cancers such as cervical cancer. Genus beta HPVs, which includes HPV types 5 and 8, have been detected in skin tumors, and previous studies suggest they may play a role in the development of these cancers. Margaret R. Karagas, Ph.D., of Dartmouth Me...Minor mutations in avian flu virus increase chances of human infection
...2-3-linked sialic acids on receptors of intestinal epithelial cells, while human viruses are usually specific for the ?2-6 linkage on epithelial cells of the lungs and upper respiratory tract. Such interactions allow the virus membrane to fuse w...Scientists discover basic defect in cystic fibrosis airway glands
...ound in cystic fibrosis is caused by a loss in the epithelial cell's ability to secrete fluid. This research ap...is to inhibit the activity of a channel called the epithelial Na+ channel (ENaC). Nam Soo Joo and colleagues at Stanford University attempted to determine which h...The American Association for Cancer Research provides support for promising cancer scientists
... YKL-40: A novel serum marker for the detection of epithelial ovarian cancer and a target for tumor directed therapy AACR-AstraZeneca-Cancer Research and Prevention Foundation Fellowship in Translational Lung Cancer Research Recipient: Anil Potti, M.D., Duke University Medical Center, Durham, N.C. Project: ...Efforts to replicate controversial diabetes therapy bring partial success
...would "rapidly differentiate into islet and ductal epithelial cells within the pancreas." "It was immediately clear that this could be extremely important," said diabetes specialist Louis Philipson, M.D., Ph.D., professor of medicine at the University of Chicago and senior author of the paper. "Patients wait ...Molecular discoveries aim at advancing early diagnosis of cancers
...Moreover, the RNA expression signature from normal epithelial cells of the upper airways in smokers identified t...etic signature of cells from the 'field of injury' epithelial cells lining the upper bronchi complemented the clinical bronchoscopy results to identify 95 percent...Another gene rearrangement involved in prostate cancer identified
...esearch. Since prostate cancer is a cancer of the epithelial cells lining organs, lead researcher Arul Chinnaiy...rangements may be responsible for other cancers of epithelial tissue, including breast, colon and lung. Scott Tomlins, a MD/PhD graduate student in Dr. Chinnaiyan...First different black/white mechanism in pulmonary fibrosis/scleroderma identified
...e growth factor (HGF) was reduced in the blood and epithelial lining fluid of African-American scleroderma patients than in Caucasians. And the latest study presented in San Francisco "demonstrates that antifibrotic effects of HGF are impaired in lung fibroblasts isolated from Africa-Americans may be due to the...Fox Chase Cancer Center study shows that inhibitors of (FAP) attenuate tumor growth in mice
...hy tissues but is expressed on the tumor stroma of epithelial cancers, melanoma, and by certain sarcomas. It has...FAP increases the growth of an experimental kidney epithelial tumor (HEK293) in mice. The DPP enzymatic activity of FAP was shown to be important for tumor growth...MIT research links cancer, inflammatory disease
...t war. TNF launches an attack, killing many of the epithelial surface cells, while EGF struggles to keep the cells alive and dividing to repair the damage. In every cell, genes create proteins, the building blocks of life. Besides carrying out the functions of keeping the cell alive, some proteins such as TNF a...Fish oil may help protect against retinal degenerative diseases
...rs may be the close association of retinal pigment epithelial (RPE) cells and the amount of docosahexaenoic acid (DHA) in them. The main role of RPE cells is photoreceptor maintenancethey conduct the daily shedding, internalization, and degradation of the tips of the photoreceptor outer segments. It now appears...