Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers
...epithelium purified from normal colon tissue. This epithelial inner lining of the colon contains about 50 million test-tube shaped crypts that line the colon. Colon cancer arises in these crypts, and researchers believe that the cells of origin are the 10-20 immortal stem cells that reside at the bottom of each...FDA grants Accentia Biopharmaceuticals...
.... The release of protein then damages the mucosal epithelial lining of the nose and sinuses, leading to the inflammatory mucosal changes characteristic of CS. Based on these insights, investigators at Mayo developed a unique diagnostic for CS -- one that tests mucus from the nose for MBP. In patients with CS...Clues to breast cancer hidden inside stem cells
... Breast cancer almost always occurs in the luminal epithelial compartment, which is also where milk is produced. Perhaps it is not surprising then, that stem cells reside in this compartment. In 2002, Thorarinn Gudjonsson, successfully isolated cells from the human breast with stem cell properties. Gudjonsson ...Genetic finding suggests alternative treatment strategy for common, complex skin disorders
...e world out of the body. "The barrier function of epithelial surfaces is important in all tissues that have contact with the outside world. In addition to the skin and respiratory tract, it includes the gastrointestinal tract, and the ocular surface," said Ali Djalilian, M.D., formerly a research fellow and me...Gains in the fight against acid aspiration lung injury
...by Bonnans et al., "Lipoxin A4 regulates bronchial epithelial cell responses to acid injury," appears in the Apr... tract. Acid aspiration into the lungs damages the epithelial barrier and initiates acute inflammation, resulting in asthma exacerbation, chronic cough, and in th...Stomach receptor for H. pylori discovered
...ecay-accelerating factor (DAF), a protein found in epithelial cells in the stomach, acts as a receptor for the b...free-living, but approximately 20% bind to gastric epithelial cells. This binding induces an immune response and alters the morphology and behavior of the epithel...Mutation in deafness gene can help heal wounds and prevent infection
...ntend to test the effect of Cx26 mutation in other epithelial cell types, such as the gut, where defence against infection is also important. "It is interesting to speculate that Cx26 deafness mutations have been selected over the evolutionary process due to their beneficial effects on wound healing," said D...OHSU study says stem cell 'fusion' occurs in tumors
...of inflammatory bowel disease, where, like humans, epithelial damage and chronic tissue repair occurs. "Ten perc...green fluorescent protein. About 60 percent of the epithelial cells were positive for both donor and recipient cell markers. A second test confirmed colocalizatio...News tips from The Journal of Neuroscience
..., and Matthew W. Kelley How is it that cells in an epithelial sheet line up with the same orientation? In this week's Journal , Montcouquiol et al. examine some of the proteins involved in this planar cell polarity (PCP) problem in the mammalian system that perhaps best illustrates the process: cochlear hair c...OHSU researcher develops first animal model to treat devasting head and neck cancers
...orming growth factor beta receptor II (TGFbRII) in epithelial cells of the oral cavity. By then introducing activating mutations in either the H-ras or K-ras (two different isoforms of the Ras GTPase), the researchers were able to induce invasive HNSCC with 100 percent incidence. "Head and neck lesions deve...Modeling head and neck cancers
... or HNSCC, as it is known) is a malignant tumor of epithelial origin, which accounts for 90% of all head and nec...orming growth factor beta receptor II (TGFbRII) in epithelial cells of the oral cavity. By then introducing activating mutations in either H-ras or K-ras (two dif...Promising cell protein may play role in infection and dry eye
...ogical crosstalk in human corneal and conjunctival epithelial cells," in Cell Death and Differentiation ( www.na...or suppressing gene Rb2/p130 in the nucleus of the epithelial cells in the cornea and conjunctiva. According to the researchers, this interaction with Rb2/p130 an...New study reveals signaling pathways required for expansion of pancreas stem cells
...rogenitor cells is thought to derive from pancreas epithelial duct cells. The pancreas of the mouse model that t...etween expansion and differentiation of pancreatic epithelial progenitors. "The complications of diabetes mellitus impose enormous medical, economic, and social c...JCI table of contents, May 18, 2006
...php?id=27236 DEVELOPMENTAL BIOLOGY Epimorphin: epithelial master regulator The normal development (morphoge...e dependent on interaction between mesenchymal and epithelial cells. Epimorphin has been identified as a mesenchymal molecule with recognized morphogenic effects....U-M scientists target key cells and signals that trigger pulmonary fibrosis
...mical signal, called CCL12 in mice, is produced by epithelial cells in damaged lung tissue. Moore's research indicates that CCL12's signal recruits fibrocytes from the bloodstream to the area of tissue damage, and helps trigger the fibrotic process. After Moore's research indicated the critical role played by ...Harvard Medical signs agreement with Merck to develop potential therapy for macular degeneration
...inal photoreceptors and associated retinal pigment epithelial cells repair these altered chromophores, but the photochemically modified chromophores can also chemically react with other molecules in the retina, especially lipids, to form toxic by-products. The most common by-products of the vision cycle compris...Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
...ors in mouse breast tissue, specifically in breast epithelial cells, in turn, promoting cell growth. Caveolin-1, Dr. Lisanti suggests, could act as a kind of "switch" that regulates receptor activity and cell proliferation. "It is the first time that we can say that the loss of function of caveolin gene express...JCI table of contents, June 1, 2006
...nter, New York, show that the ability of cancerous epithelial cells in breast tissue to spread to another organ is dependent on a signaling pathway that involves platelet-derived growth factor (PDGF) and its receptor, PDGFR. Inhibition of PDGFR signaling caused the death of mouse and human breast cancer cells i...Attack is the best defence against urinary tract infection
...We were able to show that LL-37 is produced in the epithelial cells of the urinary tracts and the kidneys, and that its build-up and secretion occur within a few minutes after a bacterial attack," says Professor Brauner. Experiments on mice showed that animals lacking the gene for an antimicrobial peptide almos...Yale ovarian cancer detection technology licensed in China by SurExam
...n of the university's blood testing technology for epithelial ovarian cancer (EOC). In the United States, EOC is the fourth most common cancer in women and the leading cause of gynecologic cancer death. EOC affects approximately 25,000 women each year, and more than 16,000 will die from the disease. SurExam ...