Other highlights in the June 21 JNCI
... Keratinocyte growth factor (KGF) is used to limit epithelial tissue damage from radiation and chemotherapy in p...erns arise over whether KGF's use in patients with epithelial tumors could lead to tumor growth or protect the tumor cells from the killing effect of radiation an...JCI Table of Contents: July 13, 3006
...hers have identified a new protein in human airway epithelial cells that regulates allergic airway inflammation....irst time that the protein aP2 is present in human epithelial cells lining the tubes that carry air from the windpipe to the lungs (bronchi), and that aP2 express...Study identifies new role for breast cancer susceptibility gene
...A1 or a related tumor suppressor, CtIP, in mammary epithelial cells (MECs). Among the 12 genes inhibited by BRCA1 or CtIP was the gene for a secreted factor, called ANG1, that enhances blood vessel growth and maturation. The researchers found that a defect in a repressor complex formed by BRCA1, CtIP, and anoth...Preventing ventilation induced lung injury depends on giving the right number of 'sighs'
...an inflammatory response, which injures the lung's epithelial lining, Bates said. At that point, doctors provide mechanical ventilation in the intensive care unit until the body heals itself. Bates explains the difficulty of treating the injured lung this way: "Imagine you have two balloons which you fill by ...Pinning down a cancer threesome
...rk is in vivo proof-of-concept of a key pathway in epithelial tumors," remarks Trumpp. "The gene that is truly critical and protects the cells from oncogenic activity is p21. Inhibiting the c-myc pathway was always thought to be unreasonable because this gene is thought to be implicated in so many cellular func...Links between DNA damage and breast cancer studied
...east cancer detection and therapy generally target epithelial cells, the primary locus of breast cancers, but in recent years evidence has accumulated that genetic mutations that develop into cancer may occur initially in a deeper layer of breast tissue, called the stroma. Genetic changes in this connective tis...Hunt for DNA amplified in cancers uncovers important target gene
... discovery that the gene YAP can transform mammary epithelial cells opens the door to understanding how a novel cell growth controlling pathway first discovered in fruit flies might be important in human cancers. This work is published in the Aug. 8 online early edition of the Proceedings of the National Academ...ACS News Service Weekly PressPac -- August 2, 2006
...nostic test. Breast cancer originates in so-called epithelial cells, and the researchers cited pilot studies suggesting that the test could work for epithelial cancers. Those include prostate cancer, ovarian cancer and melanoma. In their report, the research...Schepens Eye Research Institute scientist is ARVO's 2007 Friedenwald Award recipient
...basic and clinical understanding of wound healing, epithelial anchorage, and mucin biology in the area of ocular surface function and cornea research. The Ocular Surface Scholar at Schepens Eye Research Institute in Boston, Mass., and a Professor of Ophthalmology at Harvard Medical School, Gipson received her...New methods for screening nanoparticles
...team's studies, the scientists used lung and colon epithelial cells -- chosen to represent two likely routes of ... of lung and colon cells growing in the body as an epithelial layer. These monolayers of living cells are then exposed to varying doses of carbon nanoparticles ov...News tips from the Journal of Neuroscience
...d a much more restricted pattern limited to neural epithelial cells that express it in the ventral spinal cord, and it was expressed at much lower levels. In mice, netrin-1, which performs the function of both proteins, was expressed in a pattern similar to that of netrin-1 and netrin-2 in chicks. Thus for comm...Cigarette smoke blocks cell repair mechanism, University of Florida study shows
...ch Institute, UF researchers exposed normal breast epithelial cells to cigarette smoke condensate-a tar derived ... Center in Philadelphia who has studied how breast epithelial cells transform after exposure to the chemical benzo[a]pyrine, which is found in tobacco smoke, call...Environmental toxins may cause body's defenses to worsen lung disease
... off infection in the body, continually survey the epithelial cells lining the lungs to identify and destroy dis... is to expand existing scientific knowledge of how epithelial cells in the lungs communicate with the immune system in response to environmental and occupational ...An artificial cornea is in sight, thanks to biomimetic hydrogels
...tural and synthetic tissues. Then a clear layer of epithelial cells grow over the disc. 'Broadly interdiscipl...ering Department, is investigating how to maximize epithelial adhesion to the material. Michael Carrasco, a peptide chemist at Santa Clara University, consulted a...JCI table of contents: September 21, 2006
...elopment. Mice lacking calcineurin function in the epithelial cells of the lung were unable to breathe properly and died shortly after birth because their lungs failed to develop fully. These effects of calcineurin were mediated by a protein known as NFATc3, which was shown to activate the expression of many of...Calcineurin helps newborns breathe easy
...opment. Mice lacking calcineurin function in the epithelial cells of the lung were unable to breathe properly and died shortly after birth because their lungs failed to develop fully. These effects of calcineurin were mediated by a protein known as NFATc3, which was shown to activate the expression of many of...A new understanding of how cells defend themselves against bacterial pore-forming toxins
...lar ion concentration." The research focused on epithelial cells, the cells that line the gut and blood vesse...derstanding of the biochemical pathway that allows epithelial cells to survive an invasion by a pore-forming toxin will prove valuable as biomedical researchers t...JCI table of contents: Oct. 2, 2006
...matic water loss and diarrhea. TITLE: Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo AUTHOR CONTACT: Jerrold R. Turner University of Chicago, Chicago, Illinois, USA. Phone: (773) 702-2433; E-mail: jturner@bsd.uchicago.edu View the PDF of this a...Tissue geometry plays crucial role in breast cell invasion
...s describe a study in which the branching of mouse epithelial tubules (hollow tubes made from epithelial cells that form the network of milk ducts in the mature female breast) in culture were subjected to ......ividuals with emphysema. Expression of TLR4 in the epithelial cells of the lungs was shown to be required for maintaining the structure of the lungs by limiting expression of a protein known as NOX3. NOX3 generates oxidants and in the absence of TLR4, the oxidantantioxidant balance in the lungs was tipped towar...