UGA scientists unravel 'molecular inch-worm' structure of walking-pneumonia bacterium
...Since the organelle is involved in colonization of epithelial tissues in human lungs, finding a way to stop such attachment or gliding could halt infections or make them far less severe. "M. pneumoniae accounts for 20 percent of community-acquired pneumonias in this country," said Krause. "Finding out more ab...Ghost protein leaves fresh tracks in the cell
...cade looking at different types of cells -- mostly epithelial -- trying to learn what cues tell spectrin where to assemble in cells. They use the fruit fly as their test animal because its genetic makeup has many striking similarities to humans. "In our study, we showed spectrin doesn't have to bind to ankyrin...Researchers writing story of the 'alcoholic lung'
...e colony-stimulating factor signaling and alveolar epithelial permeability," was carried out by David Guidot, Pr... a dampened response to signaling by GM-CSF in the epithelial cells, which form the lining inside the lung. GM-CSF is a hormone that plays a role in immunity with...Plant-derived molecules, genetic manipulation point to future chemoprevention methods
...nhibits programmed cell death and stimulates colon epithelial cells, the scientists tested IGF-deficient mice for these cancer-causing characteristics. In fact, deficient mice had a decrease in proliferation in colon cells and an increase in apoptosis. The researchers were presented with a significant challe...How mammals fuel milk production may have implications for cancer
...k synthesis, the researchers said. Second, mammary epithelial cells must coordinately activate multiple biosynth... The metabolic demands of the lactating mammary epithelial cell bear many similarities to those of tumor cells in that pathways controlling energy generation a...Penn researchers discover initial steps in the development of taste
...e papillae and taste buds. "Unlike most surface epithelial cells, taste buds have characteristics of neurons as well as skin. Like other types of epithelial cells they turn over and regenerate, but they also express chemoreceptors and make synapses with neu...The biggest bug in gut discomfort
...h a large bacteria gain access to human intestinal epithelial cells that do not normally take up particles of su... jejuni gaining intracellular access to intestinal epithelial cells despite its large size suggested to Watson and Galan that the bug had evolved a special mechan...UCSF stem cell study reveals cells' capability in mouse brain tissue repair
...ted from damage of ependymal cells, which form the epithelial lining of the brain ventricles, and of neuroblasts, which evolve into neurons. Thus, it was evident that, as in embryonic mice, the proteins play a crucial role in the maintenance of cells in the region, and revealed a previously unknown function for...Cellular pathway yields potential new weapon in vaccine arsenal
... that upregulate MHC class II upon inflammation -- epithelial cells of infected organs, for instance -- one could assume that they might actually use the autophagy pathway fairly frequently," Mnz says. Then, to test the pathway's effectiveness, the researchers targeted an influenza antigen directly to autopha...Profiling of cancer genes may lead to better and earlier detection
... them to gene expression profiles from normal lung epithelial cells. The researchers then examined the gene expression profiles of these various cell types before and after treatment with a drug that inhibits methylation. The researchers identified approximately 130 genes that may be methylated and thus sile...Cease and desist -- genome stability and epithelial carcinogenesis
...gene in zebrafish that increases susceptibility to epithelial cancers. As featured on the cover of the January 1... resulted in chromosomal instability and increased epithelial tumor load after exposure to carcinogens. Lead author, Dr. Jennifer Shepard, emphasizes that "Our wo...Synthetic peptide targets latent papilloma virus infections
...s because it hides as a latent DNA in cells of the epithelial tissue, such as skin and the lining of the vagina ...rvical cancer in the world. The virus hides out in epithelial stem cells, which are nave cells at the base of the skin that can turn into many of the various type...JCI table of contents: January 2, 2007
...ines separate from our body tissues. Damage to the epithelial cell layer allows the contents of our intestines, ...ndition septicemia. Therefore, rapid repair of the epithelial cell layer after damage is essential. In a study appearing in the January issue of the Journal of Cl...Tumor-free breast tissue can have precancerous changes
...measured methylation levels in the RASSF1A gene in epithelial cells that lined the ducts. These cells were the sources of the initial tumor. As expected, tumor cells showed the highest methylation levels. But the researchers found significant methylation levels in normal tissue adjacent to the tumors in 29 pa...Leading cause of US food-borne illness makes its own pathway through cells
...wo decades that campylobacter can enter intestinal epithelial cells -- but until now no one could show how it was taken up or where it localized. That suggested it had evolved a special mechanism for uptake," said Watson. "Campylobacter seems to have found a special access to these cells and established its own...Scientists crack the genome of the parasite causing trichomoniasis
...secretes a series of proteins that destroy vaginal epithelial cells, which make up the surface of vaginal tissue...es a series of proteins, which destroy the vaginal epithelial cells, the cells that make up the vaginal tissue surface. For the first time, the genome project man...A new target for the treatment of breast cancer
...phenotype very reminiscent of non-malignant breast epithelial cells." Kenny is the co-author along with Bissell of a paper published in the Journal of Clinical Investigation entitled: Targeting TACE-Dependent EGFR-ligand Shedding in Breast Cancer. This paper presents the latest experimental results from an o...Selective marker found to indicate aggressive form of breast cancer
... represent a selective biological marker for basal epithelial breast tumors, a highly aggressive cancer with sim...ncer before it has a chance to come back." Basal epithelial tumors lack important molecular targets such as the estrogen receptor, progesterone receptor and Her...UCLA and NYU microbiologists crack genome of a parasite that causes a common STD
...aginal lining and is capable of destroying vaginal epithelial cells, which make up the surface of this tissue, Johnson said. This results in vaginitis, with irritation of local tissues. Erosion of cervical tissues may occur, and complications can result in sterility. A big threat from infection also occurs in p...Carbon monoxide protects lung cells against oxygen-induced damage
...ignificant damage to many cell types including the epithelial and endothelial cells of the lung. However, by administering oxygen mixed with a very small amount of carbon monoxide, we may be able to significantly reduce such oxygen-associated damage and cell death." Although high concentrations of carbon mono...