Linheng Li Lab documents the development of cancer stem cells
...2. "We found that a loss of PTEN in intestinal epithelial cells accompanied by a loss of PTEN in stromal cells can lead to changes that may increase the number of stem cells and change their position or location," said Dr. Li. "These changes result in crypt fission and budding and can lead to intestinal pol...Reactivated gene shrinks tumors
...hers are looking at other types of cancer, such as epithelial (skin) cancer, in their mouse model, and they plan to see if the same approach will also work for tumor suppressors other than p53....Biogen Idec acquires Brandeis spin-out
...ansports antibodies and Fc-fusion drugs across the epithelial cell barrier in the lungs. About Hemophilia Hemophilia is a rare, inherited bleeding disorder that is caused by mutations that impair or eliminate the production of essential clotting factors naturally found in the blood. Hemophilia B, caused by ...JCI table of contents: Feb. 1, 2007
...rg/article.php?id=31290 PHYSIOLOGY: What makes epithelial cells change their identity? During development ...s, and tumor metastasis, is the transition from an epithelial cell to a mesenchymal cell (often a fibroblast). This change in cell type and function is known as e...UT-Houston scientists develop new procedure to differentiate human embryonic stem cells
...ve created the first transplantable source of lung epithelial cells. The process, created in the laboratory of...of the article, A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. We have developed a reliable molecular proc...JCI table of contents -- March 1, 2007
...dy and how much excrete in our urine by activating epithelial Na+ channels (ENaCs). In this way it has a major i...es Dot1a-Af9mediated transcriptional repression of epithelial Na+ channel-alpha AUTHOR CONTACT: Bruce C. Kone University of Texas Medical School at Houston, Hou...JCI table of contents -- March 8, 2006
...how that in vivo expression of SPDEF in mouse lung epithelial cells is increased by IL-13 (a soluble factor asso...ression of genes encoding proteins that caused the epithelial cells to become goblet cells and to produce mucous proteins. This study therefore indicates that SPD...Researchers identify molecular basis of inflammatory bowel disease
... a protein needed to activate NF-kB, in intestinal epithelial cells. As a result, these mice developed severe ch...happened in the intestines of our mice; individual epithelial cells died disrupting the gut lining." Through these gaps bacteria could penetrate the intestinal wa...Other highlights from the April 18 Journal of the National Cancer Institute
...cribe should be useful for isolating tumor-forming epithelial cells from their primary DCIS lesions to allow a better understanding of their growth," the authors write. Contact: Gillian Farnie, Ph.D, of the University of Manchester, 0161 446 3212, Gillian.Farnie@manchester.ac.uk Shortened HER2 Gene...University of Texas researcher earns APS Bowditch award
...exas Health Science Center at San Antonio, studies epithelial sodium channels in the cells of the kidney, lungs and colon. His research may lead to a better understanding of how these cells regulate salt and could one day be used to control hypertension. Its not going to happen tomorrow, but this research wil...Master regulatory gene of epithelial stem cells identified
...generation process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be the p63 gene, a close relative to the well-known tumor-suppressing p53 ge...Clinical trial data regarding NKTR-061 will be presented at ATS International Conference
... in high tracheal aspirate concentrations and high epithelial lining fluid concentrations of amikacin in gram-negative pneumonia in intubated mechanically ventilated patients. Finally, data will be presented indicating that NKTR-061 achieves safe serum concentrations following multiple dosing in intubated mech...Herpes infection may be symbiotic, help beat back some bacteria
...ts from viral infections that live in areas beyond epithelial surfaces like the skin, throat or intestines. For the new research, Virgin's group worked with strains of mouse herpes virus closely related to human Epstein-Barr virus, Kaposi's sarcoma-associated herpes virus and cytomegalovirus. During studies of...HIV in breast milk killed by flash-heating, new study finds
...ants in solid foods and formula can compromise the epithelial lining of a baby's digestive tract, making it easier for viruses to pass through. For this reason, WHO guidelines have recommended that after six months of exclusively breastfeeding, HIV-positive mothers wean their babies as soon as other foods are...JCI table of contents: May 24, 2007
...s that are able to adhere to and invade intestinal epithelial cells. In a study appearing online on May 24 in ad...ve E. coli (AIEC) adhere to a region of intestinal epithelial cells known as the brush border in patients with Crohn's disease, but not in healthy individuals. Th...Stuck on you: CEACAM6 helps E. coli stick to intestinal lining in Crohn's disease
...s that are able to adhere to and invade intestinal epithelial cells. In a study appearing online on May 24 in ad...ve E. coli (AIEC) adhere to a region of intestinal epithelial cells known as the brush border in patients with Crohn's disease, but not in healthy individuals. Th...Molecular motors may speed nutrient processing
...ell surface. Microvilli are common features on the epithelial cells that line the bodys cavities. At the time, T...the brush border to be absorbed by the (intestinal epithelial cell)," Tyska said. The team is also exploring other possibilities for the role of membrane shedding...Scientists develop new drugs to fight colon and breast cancer more effectively
...cer, but it can also affect the rest of the benign epithelial tissue. As everybody knows, current treatments for cancer destroy a large number of unaffected cells in addition to affected cells, says Caba Prez. In this study researchers analyzed more than 150 drugs aimed at reducing the toxicity of the 5-FU ag...NIAID supports research into etiology of fungal-induced inflammation in chronic sinusitis
...eMBP) in the mucus, which then damages the mucosal epithelial lining of the nose and sinuses and leads to the inflammatory mucosal changes characteristic of CS. Dr. Jens Ponikau, Assistant Professor of Clinical Otolaryngology, University at Buffalo, commented: Research supported by the National Institutes of ......identify the key signaling molecules that regulate epithelial stem cell proliferation in the stem cell niche. Th...nals from the adjacent mesenchymal tissue regulate epithelial stem cells and form a complex regulatory network with epithelial signals. They also show that spatia...