New DNA repair enzyme makes mistakes to save lives of cells
... base or one that is damaged. If a problem somehow evades detection, it can prevent DNA from being replicated or result in a mutation in the copied DNA. The researchers found POL-Q's role is to detect late-stage mishaps in the replication process, specifically those that are found at a juncture called the ...NC State gets $1.59M grant to map genome of parasitic worm
...velops, establishes a host-parasite interaction or evades host defenses, for example will then be able to use the map of the parasite's genes as a tool to discover more specific information about the parasite. The root-knot nematode will be the first parasitic nematode to have its genome sequenced, Opperma...Dream home: Malaria parasite renovates to suit its tastes
...conced in its newly refurbished home, the parasite evades detection by the host's immune system. Alan F. Cowman, a Howard Hughes Medical Institute (HHMI) international research scholar at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, and colleagues report on studies that r...Ancient immune defense mechanism is no match for HIV-1
...tic strategies making use of RNAi. "Because HIV-1 evades all other RNAi by point mutations, we reason that its requirement for an SRS is solely to shield this last 'Achilles' heel that we think HIV-1 cannot alter for functional reasons. The sequence we describe may represent a viable target for RNAi that ...MSKCC researchers uncover structure of key protein complex in cells
...or destruction. But in cells with damaged DNA, p53 evades getting tagged with ubiquitin to allow its accumulation, thus enabling the p53 suppressor protein to stifle the formation of tumors. Three scientists -- two Israelis and an American -- were awarded the 2004 Nobel Prize in Chemistry for their work sho...Scientists streamline method for making key virus
... how the virus replicates, infects host cells and evades the immune system. It also promises to speed development of therapeutic drugs and new vaccines, including live, attenuated vaccines, according to Dohun Pyeon, the lead author of the report. "This new approach offers dramatic advantages," says Paul Ah...Frog peptides block HIV in lab study
...l surface by a sentinel dendritic cell, it somehow evades destruction. Instead, it hides inside the cell, waiting to invade the T cell with a Trojan Horse-like mechanism. The ability of HIV to remain hidden in the dendritic cell, avoiding destruction by circulating antibodies and immune system cells, "may e...Scientists lift malaria's cloak of invisibility
...Using this versatile surface protein, the parasite evades the host's immune system using two basic strategies. First, the protein sticks infected red blood cells to the blood vessel lining, removing the infected cells from circulation, where they would probably be destroyed. But the protein cannot protect ...Scientists uncover critical step in DNA mutation
...rings about a change in the DNA molecule one that evades the body's proof reading mechanism and leaves the altered DNA coding for the wrong proteins. When the wrong proteins are produced, it can lead through a complicated chain of events to an abnormally high rate of cell division the result is cancer. ...Study gives clues about how deadly bacterium gains foothold
.... The team focused on how Francisella tularensis evades being killed by a form of white blood cells called neutrophils. Normally, neutrophils can be quickly activated in response to infection, making them the equivalent of "first responders" for the human immune system, Allen said. "We knew that Franci...UT Southwestern joins national clinical trial to uncover long-term effects of West Nile virus
...re studying at the molecular level how the disease evades the body's immune defenses in hopes of finding a vaccine to protect against the harmful North American strain of the West Nile virus. For now, avoiding mosquito bites is the best prevention. Physicians recommend wearing insect repellant that contai...