JCI table of contents November, 2005
...till controversial. There is evidence that a link exists between atherosclerosis and a family of proteins called toll-like receptors (TLR), which recognize components of microbes as well as some endogenous proteins. In particular, the roll of TLR-2 in atherosclerosis has been hard to pin down. In a pape...Image of myosin-actin interaction revealed in cover story of Molecular Cell
...is the workhorse of the myosin protein family. It exists to ferry a cargo of proteins needed in a specific place at a specific time. Fueled by hydrolysis -- the process of converting the molecule adenosine triphosphate (ATP) into energy -- myosin V travels in one direction using actin as a track to deliver...Study points to molecular origin of neurodegenerative disorders, including Huntington's disease
...C co-authors sought to determine why a correlation exists between polyglutamine expansion length and nerve cell death, or disease. They hypothesized that expansion of glutamines results in alternative structures forming within the protein that compete with its normal structure and function. "As a result, t...Nanowires can detect molecular signs of cancer, scientists find
...l technique that is significantly better than what exists today," says author Charles M. Lieber, Mark Hyman Jr. Professor of Chemistry in Harvard's Faculty of Arts and Sciences. "A nanowire array can test a mere pinprick of blood in just minutes, providing a nearly instantaneous scan for many different canc...'Underground' tunnels discovered as means for communication between immune system cells
...thing to find that this intricate physical network exists but quite astonishing to learn that immune system cells are using it to relay molecular signals to one another," said Dr. Watkins, professor and vice chair, department of cell biology and physiology, and director of the Center for Biologic Imaging, U...Mammalian transcriptome mapped, and it makes antisense
...arts, but the extent to which antisense expression exists has never been guessed at before. The stunning thing is that the majority of genes are seen to have an antisense counterpart. To get an idea of what antisense RNA is, it's necessary to understand something about how and why RNA is made in the cell. T...UCSF study points to link to neurodegenerative disease target
...us system is a complex pattern of connections that exists for the entire life of the organism, and understanding how the myriad patterns and pathways of these connections are maintained for long periods of time presents an ongoing challenge to scientists, says Davis. Davis and co-author Benjamin Eaton, PhD,......like the other p53 family members p63 and p73, p53 exists in human cells in at least six different isoforms. Dr. Lane and colleagues identified a heretofore unrecognized internal promoter and alternative splice exons in p53 mRNA. While further research is needed to delineate how the various p53 isoforms af...New ivory-billed woodpecker recordings to be released
...of the area in 2004-05. Whether more than one bird exists is still a big question, Charif said, but quantitative analyses of the most promising sounds indicate a high probability that they were made by ivory-billed woodpeckers. The sounds were recorded on autonomous recording units (ARUs) designed by the Co...Bacteria are key to 'green' plastics, drugs
...roduce succinate in two different ways. One method exists in wild strains of E. coli and has been modified with the deletion of four genes, each of which codes for a protein that interferes with or limits E. coli's ability to turn glucose into succinate. Bennett and San activated a second pathway and stimul...Mouse model of Rett Syndrome displays reduced cortical activity
...ntal evidence for a physiological abnormality that exists before symptoms appear. "It's important to note that since this defect is seen so early it suggests that the reduced cortical activity may be a primary cellular defect that may lead to other neuropathologies," shared Qiang Chang, co-first author on ...Old drug, new tricks: Prospects for slashing the impact of malaria
...izational and public health infrastructure already exists to dispense the tablets in a controlled way, since PNG's children routinely attend clinics to be vaccinated against a range of other diseases. The project funding allows significant expansion of joint activities and research among the collaborating ...Locusts' built-in 'surface analysis' ability directs them to fly overland
...ht. This is a trait which is lacking in humans but exists among other species, such as fish and insects. The research was conducted by Dr. Nadav Shashar, who is considered a leading world expert on polarized sight, working with two students, Shai Sabah and Noa Aharoni. The research was published in a recent......s, along with soil samples, to determine if a link exists between the acidity levels of the soil and avian populations. The presentation is part of the organized oral session "Biodiversity: soils and seeds." Friday 12 August, 8:00 11:30 AM, Meeting Room 513 E, Level 5, Palais des congrs de Montral For mo...JCI Table of contents August 1, 2005
..., including growth, survival, and metabolism. Akt exists in three isoforms Akt1, Akt2, and Akt3, which have a substantial degree of functional overlap. In the heart and vasculature, Akt may be protective against ischemia and it may enhance cardiac function after heart failure. But Akt may also have detr...3 papers present fresh paths to ponder Akt1 in the heart
..., including growth, survival, and metabolism. Akt exists in three isoforms Akt1, Akt2, and Akt3, which have a substantial degree of functional overlap. In the heart and vasculature, Akt may be protective against ischemia and it may enhance cardiac function after heart failure. But Akt may also have detr...Researcher uncovers details of how cancer spreads
...em for cancer cells, which means its basic pathway exists in real-world systems, while the actual proteins that act on the system may vary. In the model system, the researchers discovered critical differences between cancer cells and normal cells regarding a mechanism called endocytosis -- which cells empl...New understanding of cell movement may yield ways to brake cancer's spread
...al widely used laboratory models, but the molecule exists in nearly all animals, from roundworms to mammals, and likely has a conserved function throughout species. Knowing exactly what triggers cellular migration can help develop treatments that halt cancer metastasis and immune disorders like arthritis an...Census of Marine Life explorers surprised by diversity, density of Arctic creatures
...odiversity surprising deep-sea explorers worldwide exists as well in deep Arctic waters, the most under-studied area of the ocean world." Baseline data about such long-inaccessible marine species will have growing importance for measuring impacts of climate change and, should polar caps continue receding,...Tufts nutrition scientists say it is premature to focus on nutrient supplements over diet
...ng causal connections. "Perhaps no better example exists than the disheartening results of the vitamin E intervention trials for the prevention of cardiovascular disease," says Russell. Lichtenstein explains that although observational studies suggest positive effects, "we lack supporting evidence from int...