A clue to core problem of neurodegenerative disease and cell death
... with innumerable cellular processes and offers an explanation of why so many different mechanisms have been proposed for toxicity and cell death." Morimoto speculates that it could be the misfolded protein's structure that, indirectly, is causing the other proteins to become non-functional. If so, these finding...Veggies contain chemicals that boost DNA repair and protect against cancer
...s study is one of the first to provide a molecular explanation as to how eating vegetables could cut a person's risk of developing cancer, an association that some population studies have found, says the study's senior author, Eliot M. Rosen, MD, PhD, professor of oncology, cell biology, and radiation medicine a...Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
...rs." The researchers' analysis revealed a possible explanation for the two responses. They found significant diff...c and Tung have presented a convincing mechanistic explanation for a clinically important phenomenon that they reproduced in a Petri dish," Igor Efimov and Crystal...JCI table of contents, February 1, 2006
...allergen exposure) may warrant consideration as an explanation for excessive mucus production, and may be targets of future therapeutic strategies for obstructive lung diseases. In an accompanying commentary, Lauren Cohn from Yale University School of Medicine in New Haven, Connecticut, points out that these st...Public support for environmental protection on the decline
...se to 65 percent. Greenberg tends toward the first explanation competing public concerns noting that before 2001, an average 93 percent of respondents considered environmental protection a "top" or an "important" priority and that after, 88 percent felt the same. "A little over three decades ago, most U.S. res......skeleton offered the first evidence for a possible explanation for the observed synapse changes. Actin is a central protein in the cell's skeleton, which keeps synapses in shape. Formless synapses in Staufen2-deficient nerve cells have significantly fewer actin fibres than normal synapses. The mRNA for actin is ...Avian influenza virus in mammals spreads beyond the site of infection to other organ systems
...e at sites containing viral proteins, providing an explanation for the increased severity of disease in humans. These data underscore the potential for influenza virus to spread not only from the respiratory tract but also from the digestive and urinary tracts, greatly increasing the possible routes of mammalian...Why the brain has 'gray matter'
...Minimizing Conduction Delays") provides a possible explanation for the structure of various neurological regions including the cerebral cortex and spinal cord. The research was carried out at Cold Spring Harbor Laboratory on Long Island by theoretical neuroscientist Dmitri Chklovskii and graduate student Quan We...Unified physics theory explains animals' running, flying and swimming
...ms of locomotion exist. The findings also offer an explanation for remarkable universal similarities in animal de...Marden said. "It was fascinating, but there was no explanation for this commonality when so much about the animals seemed to be different." Years later, a student ...Researchers discover how a high-fat diet causes type 2 diabetes
...eta cells. The experiments point to a mechanistic explanation for why failing pancreatic beta cells don't sense glucose properly and how that can lead to impaired insulin production, said Jamey Marth, a Howard Hughes Medical Institute investigator at the University of California, San Diego (UCSD). Marth and fir...Illuminating Alzheimer's: Research sheds light on creatine's presence in brain
...nd maybe in other diseases. But as to the detailed explanation of why (the disturbance) is there - the jury is still out."...ASU geologists suggest Mars features are result of meteorite strikes, not of evaporated lakes
...eorite strikes offer a simpler and more consistent explanation for the rock formations and sediment layers found ...forms. Impact surges "present a simple alternative explanation involving deposition from a ground-hugging turbulent flow of rock fragments, salts, sulfides, brines...Plant defenses prompt bacterial countermeasure in the form of 'island' DNA excision
... host bean plant. These findings offer a molecular explanation for how exposure to plant resistance mechanisms can directly drive the evolution of new virulent forms of a bacterial pathogen....Chlamydia parasite lives off our fat
..., lipid droplet co-option also suggests a possible explanation for the association between chlamydial infections and heart disease....Getting old? Slowing down? Blame inefficient mitochondria
...his represents a 50% loss in efficiency. "The best explanation for this loss of efficiency is that the mitochondria become leaky as they get old. Protons leak back into the mitochondria without making ATP, and so reduce the coupling between oxygen use and ATP production," says lead author David Marcinek, who wor...New insights into protein synthesis and Hepatitis C infections
...on of eIF3 in our models also provides a plausible explanation for its role in preventing premature joining of the 40S and 60S ribosome subunits." Doudna and members of her research group are now working to improve the resolution of these models from 30 angstroms to about 10 angstroms. This would allow them to...From intelligent cars to the prevention of heart attacks
...ability to adapt, as well as to arrive at a fuller explanation for the biodiversity we observe around us. (Coordinator: Prof. Diethard Tautz) University of Munich The constantly increasing number of people with cancer demands an urgent improvement in early diagnosis and therapy of tumour diseases. The Collabor...NSF funds probe of the quintessence of surprise
...xperimental evidence suggests a novel mathematical explanation of how brains measure "surprise" in a data stream--a theory that an NSF funded study will explore. Information theorists Pierre Baldi of UC Irvine and Laurent Itti of the University of Southern California are joining with electrophysiologist Douglas ......ies are important because they begin to provide an explanation for the "life extension" effect seen in laboratory animals when food is restricted. So the studies could offer new clues about the molecular mechanisms that living organisms employ when food is scarce, said Fields. Although it seems counterintuitive,...