Cell-regulating gene may predict survival outcomes for breast cancer patients
...vels of cyclin D1. "Our study provides a potential explanation for the beneficial effect of cyclin D1 in breast cancer and suggests that by amplifying this effect, bortezomib may be a useful treatment," he says. "A genetic profile of a patients' breast tumors could yield a great deal of information and help clin...'Stress and the city': Urban birds keep cool
...first autumn is still an unanswered question. "One explanation is that the reduced sensitivity of urban blackbirds to stressors occurs later in their life," speculated Partecke. Data obtained from free-ranging birds in their native urban and forest habitats are also inevitably necessary to verify the observed pa...JCI table of contents: September 1, 2006
...the immune system, this study provides a potential explanation for why only healthy individuals, and not individuals whose immune system is compromised, are able to control infection with T. gondii: CD40L-expressing cells are only available to trigger macrophage destruction of T. gondii in healthy individuals. ...Viral oncoprotein inactivation of p53
...ins that "The X-ray structure provides a molecular explanation for the oncogenesis potential of the virus oncoprotein LTag. LTag induces the conformational change of p53 protein through physical interactions. By doing so, LTag abolishes the tumor suppressor function of p53, which can lead to genomic instabilit...An irregular heartbeat makes exercise deadly
...rom Vanderbilt University has provided a potential explanation for why the heartbeat of humans lacking the protein cardiac calsequestrin (CASQ2) is irregular, and potentially fatal, only during exercise and not at other times. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a life-threatening ...JCI table of contents: August 24, 2006
...rom Vanderbilt University has provided a potential explanation for why the heartbeat of humans lacking the protein cardiac calsequestrin (CASQ2) is irregular, and potentially fatal, only during exercise and not at other times. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a life-threatening d...Researcher hits bulls-eye for antibiotic target
...d. "This is extremely rare and provides a physical explanation of why it is so processive. The hole physically encompasses the substrate, keeping it in place, in addition to the usual chemical bonding that keeps it attached. Once the protein attaches to the substrate, it doesn't come off. The protein chews away ...Why piglets shudder to keep warm
...aintain body temperature after birth. A reasonable explanation for this is that brown fat was not essential during a period in the evolution of pigs, in which they lived in a warm climate, says Leif Andersson, who directs the research team. The ancestor of the domesticated pig, the wild boar, is the only pig t...Unusual data shed new light on brain and inhibiting behavior
...chers may have tapped into a developmentally based explanation for why kids respond as they do. A study of eye movements of 41 individuals, ages 4 to 29 and divided into four age groups, led to the discovery that younger people simply don't have the ability to ignore secondary targets, even when told in advanc...Insulin pathway component explains insulin resistance, age-associated metabolic syndrome
...ent decline of heart function, providing a partial explanation for why excess calories from overeating can lead to resistance to insulin's ability to process sugars and may contribute to reduced heart function. Dr. Oldham and his colleagues are continuing their search to understand how TOR mediates caloric ...Germans do well in the third round of EURYI Awards
... stem cells. He hopes not only to provide a better explanation of the molecular mechanisms, but also to indicate possible strategies for the maintenance of hippocampal functioning in older people. Dr. Frank Keppler (38), Natural Sciences, Max Planck Institute for Nuclear Physics, Heidelberg Frank Keppler, ...Magnetism and mimicry of nature hold hope for better medicine, environmental safety
...ire only miniscule amounts of fluids. A detailed explanation of the process is presented in an article published in the July 17 edition of Applied Physics Letters, a leading international journal reporting on significant new findings in physics applied to engineering, technology and other sciences. The article...Direct link established between tropical tree and insect diversity
... number of tree species in the tropics is the best explanation for higher insect diversity. Only 2 million of the estimated 5-10 million insect species on this planet have been identified. Nearly nothing is known about the behavior or environmental impact of most insect species. The conclusion that tree div...Tyrannosaur survivorship -- tough times for teens
...imated survivorship curve also provides a possible explanation for the rarity of individual giants--just two per cent of the population lived long enough to attain maximal size and age for the species....UCR researchers determine genetic origin of California wild radish
...ir research the scientists will look for a genetic explanation for how the hybrid acquired its invasive behavior. Said Hegde, "This approach could help us find a way to control the spread of other plants that evolved invasiveness after interspecies hybridization." ...miRNA-mediated silencing of mRNAs
...by induction of mRNA degradation. This provides an explanation for changes in mRNA levels observed at least for a subset of miRNA targets."...'Thirst for knowledge' may be opium craving
Neuroscientists have proposed a simple explanation for the pleasure of grasping a new concept: The br...perience, Biederman said, providing a neurological explanation for the pleasure we derive from art. "This account may provide a plausible and very simple mechanism...HIV-1's high virulence might be an accident of evolution
...ional team of researchers is the first to offer an explanation for this striking difference. The group found that a viral protein earlier shown to help the virus evade the immune system, thereby allowing the SIVs that infect monkeys to persist and multiply with high efficiency, also has a protective role in the ...Drug offers new options for leukemia patients
...rect result of researchers' learning the molecular explanation for why patients develop resistance to Gleevec. Sa...cer patients at UCLA, has long been hunting for an explanation of Gleevec resistance. The development of dasatinib is deeply rooted in scientific literature spanni...Bacteria have their own immune system protecting against outside DNA
...ry author of the study. "This research gives us an explanation of how pathogenic bacteria have evolved over millions of years." The researchers also learned that the H-NS protein is able to recognize foreign DNA on the basis of its increased content of adenine and thymine, the building blocks of DNA. "It has bee...