Tag: "expression" at biology news

NIH awards new $14.5 million, five-year grant to the Scripps Research Institute

...On the production side, they will look at improved expression of membrane proteins by using insect or mammalian ...y," says Stevens. Yeager will be focusing on the expression of membrane proteins in mammalian and other types of eukaryotic cell lines. Eukaryotic cell lines ha...

DNA sequence controls expression of gene involved in cancer

... of the mutated cells and eventually cancer. The expression of the bcl-2 gene is regulated both transcriptiona...f a new region on the bcl-2 gene that controls its expression may be big news for cancer therapy. Several drugs that reduce the amount of bcl-2 present in the cel...

Talented sniffer: A receptor known for guiding sperm to egg plays a role in the nose

... of experimental approaches. They demonstrated the expression of hOR17-4 in the human nose by using standard molecular techniques, whereas they tested and demonstrated the actual function of the receptor in a simple "sniffing test" as well as with electrical recordings from nasal sensory tissue (by electro-olfa...

Research team develops nonhuman primate model of smallpox infection

..., Rubins and her colleagues examined the host gene expression patterns of hemorrhagic smallpox in these animals. Specifically, they documented fluctuations in cellular proliferation, interferon, and viral modulation of the immune response. A better understanding of the disease process that occurs with smallpox ...

Daphne Koller named MacArthur Fellow

...tic that she can help to identify patterns of gene expression across species as her methods are further developed. When asked what she plans to do with the award, Koller said that the matter will require significant thought. "It's really a major decision, and they give you some time to think about it." The ...

Is Interleukin-6 the 'holy grail' of exercise mediation?

...ms. Indeed, it's possible, for instance, that IL-6 expression may be up-regulated in insulin resistant skeletal muscle in an attempt to overcome the impaired glucose uptake. And in other contexts, the current thinking is that IL-6 has primarily anti-inflammatory effects. It is this combination of effects that h...

New genetic tools provide clues to the effects of exercise and diet on obesity, diabetes

...nt study "indicate the widespread and differential expression of metabolic, contractile and signal transduction ...the proteomics side, the researchers analyzed gene expression and protein profiles from muscle of lean and obese and morbidly obese individuals. "This combination...

After flu exposure, mild exercise protects mature mice from dying

...de: lung histopathology, cytokine gene and protein expression in the lung, and possible development of flu-specific immune cells. At the moment, the laboratory also has a large NIH-funded human clinical trial underway examining whether or not moderate exercise training can improve immunological vigor --includin...

Embryonic stem cells correct congenital heart defect in mouse embryos

...artial rescue of cardiac defects and abnormal gene expression profiles. As a result, Id knock-out pups whose mot...WNT5a had the ability to correct the abnormal gene expression profiles of the Id knock-out hearts to normal levels. These two mechanisms (long- and short- range a...

'Junk' DNA may be very valuable to embryos

...d become embryos. Researchers have discovered that expression of genes in mouse eggs and very early embryos is a...onal, may play some role in the regulation of gene expression and promotion of genetic diversity. Dr. Barbara B. Knowles and colleagues from The Jackson Laborato...

Researchers provide road map for generating B cells from stem cells

... a lymphoid progenitor, stage 2. They trigger the expression of certain receptors on the cell surface, such as Flk2 followed by IL-7R, which are necessary for receiving subsequent external signals. In the next step, the gene for a regulatory protein known as E2A cooperates with PU.1 to activate another regulat...

Genetic link to risky pregnancy

...n with and without a history of preeclampsia. The expression of a particular type of protein on the trophoblast in combination with its receptor on NK cells was more common in women with a history of preeclampsia. This protein combination is expected to deliver a signal that suppresses the NK cells, robbing t...

Acoustics meeting in San Diego

...ue to synthesize human laughter, a complex mode of expression that varies greatly from individual to individual....sation. Similarly, this technique aims to make the expression of laughter in computer-generated speech more effective and natural. (1aSC11) CLASSROOM ACOUSTICS: ...

New study on smallpox in monkeys reveals tactics of a killer

...nalysis of how the smallpox infection altered gene expression patterns in the monkeys' blood cells. Dr. Relman u...e virus. It also reveals changes in levels of gene expression and expression of some proteins in the blood of monkeys when they are infected with smallpox virus. ...

Rutgers-led research offers new clues in the genetic mysteries of maize

... genome sequence, a more detailed analysis of gene expression in maize, and a better understanding of its genetic and cellular mechanisms. ...

Estrogen protects male rats from aortic aneurysms

...MMP-9 protein and 10 times the level of MMP-9 gene expression compared to the same cells from female rat aortas. Known to be involved in AAA formation, MMP-9 is a cell-digesting enzyme that eats away at the wall of the aorta, leaving it vulnerable to expansion and rupture. However, when Woodrum treated male ra...

Study in Royal Society journals presents evidence for inherited factors in homosexuality

...ntitative evolutionary genomics: differential gene expression and male reproductive success in Drosophila melano... in competition with other males). We measured the expression level of over 14,000 genes in the fruit fly and identified 27 that were strongly associated with dif...

Technique for genetically modifying blood stem cells brings cure for blood diseases closer

...R), which has overall operational control over the expression of the gene. The St. Jude team used these regulato...t. "The enhancement in expression of the gamma-globin gene that was key to the success of this new vector was due to the additional co...

Channel protein converts vibrations to electrical signal

...time. When the researchers tested for TRPA1 gene expression in developing mouse embryos, they found that the gene became active when the embryo was about 16 days old just a day before hair cells become mechanically sensitive. Next, the scientists looked for TRPA1 within the hair cell. In frogs and mice, a...

A new culprit in depression?

...sed people. "We can't say whether these FGF gene expression changes are a predisposing factor for depression, or a consequence of the disease process itself," says lead author and U-M research investigator Simon Evans, Ph.D. "There may be totally normal people out there with compromised FGF systems, but if th...

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