Tag: "factor" at biology news
Other highlights in the November 3 JNCI
...ing to a new study. Obesity is an established risk factor
for endometrial cancer, and there has been some evidence that body mass at younger ages, weight change, height, and physical activity may also be associated with a woman's risk of this cancer. To investigate these possible associations, Leo J. Schout...
Growth factors confer immortality to sperm-generating stem cells
...ic factor, was originally identified as a survival factor
for neurons in the brain. GDNF was also found to be excreted by the Sertoli cells that surround and support the spermatogonial stem cells in the testes. Once added to the culture, GDNF caused the stem cells to form dense clusters and proliferate co...
A new target for control of obesity
... the body and is implicated in a variety of growth factor
or cytokine pathways present in these cells. The physiological function of Shp2 is largely unknown. Whether it is active in multiple pathways or focused on a single pathway remains to be seen. In recent years, in vitro experiments suggest that ...
Young adults who maintain their weight have lower risk factor levels for heart disease
...time, even if they are overweight, have lower risk factor
levels for heart disease and are less likely to de...e changes produced substantial differences in risk factor
levels. Normal-weight men who maintained their weight had only a 1 mg/dL rise per year in triglycer...
UO study is first to link histamine receptors to heat stress
... flow during heat stress. Skin blood flow is a key factor
in compensating for exposure to prolonged heat waves. "These are the same receptors that are involved in seasonal allergies for which people take antihistamines," says Wong, who is the lead author on an article describing his findings in the Novem...
Genetic variant linked to weakened heart pumping
... have discovered that a variant of a transcription factor
crucial to the regulation of a cell's metabolism i...r-activated receptor-alpha (PPAR), a transcription factor
that regulates the use of fatty acids within cells. Transcription factors such as PPAR are proteins ...
Research effort seeks A's to gene expression Q's
...ning of an organism. It also can indicate, or be a factor
in, many diseases. The mechanisms of gene regulation are poorly understood---recent research, for example, suggests that a great deal of gene regulation information may be encoded in long stretches of DNA previously written off as "junk." Gene expres...
New gene target found for common brain tumors in children
... Notch2, whose pathway is known to be an important factor
in regulating brain stem-cell growth and survival, has been studied in fruit flies for almost a century. The research team at the Johns Hopkins Pathology Department and Kimmel Cancer Center found that a protein made by the Notch2 gene promotes cance...
Reduced fish stocks linked to increased bushmeat trade, wildlife declines in W. Africa
...frica, with EU fish harvests there increasing by a factor
of 20 from 1950 to 2001. Arcese says the results support arguments that he, Sinclair and other biologists and agricultural economists have made for over a decade that urgent measures are needed to develop local sources of cheap protein alternatives ...
Brain-derived neurotrophic factor (BDNF) appears to modify elements of alcoholism
...amines the influence of brain-derived neurotrophic factor
(BDNF) on the dopamine system. Findings indicate ...system. In particular, brain-derived neurotrophic factor
(BDNF) can influence both dopamine and serotonin neurotransmitters, which are heavily linked to addi...
New findings may redirect strategies for treatment of prostate cancer
...state cancer therapies. The AR is a transcription factor
that plays a major physiological role in normal male sexual development and contributes to the progression of prostate cancer. About one-third of prostate cancer patients develop metastatic disease and receive treatment to block androgen production a...
JCI table of contents, November 15 2004
...*** Inactive form of scatter factor
protein found to suppress tumor growth and spread Scatter factor
(SF) is a growth factor
that controls the proliferation and survival of many tissues by promoting in...
Inactive form of scatter factor protein found to suppress tumor growth and spread
(SF) is a growth factor
that controls the proliferation and survival of many tissues by promoting invasive growth in both no...
How running made us human
...ly why many scientists have dismissed running as a factor
in human evolution. Human endurance running abilit... human genus, and its demands a major contributing factor
to the human body form."...
Study shows stem cells can preserve vision
...lated that the transplanted cells were secreting a factor
or substance that saved these fragile cells. (There is growing evidence that rod cells keep cone cells alive by secreting a special factor) To test whether the mice with transplanted stem cells could see better, the team then placed them and the cont...
Researchers discover defense mechanisms in some plants believed bred out by humans
... another protein, the beta-glucosidase aggregating factor
(BGAF), which NULL lines produced in excess. They isolated BGAF and proved its aggregating activity. After further study, the scientists found that BGAF was a hybrid protein with two distinct regions or domains, a disease-response region and a...
Down Syndrome protein reduces tumor growth
...tain agonists, such as vascular endothelial growth factor
and the serine protease thrombin, cause endothelial cells to increase their expression of genes involved in proliferation, inflammation, and thrombosis. Dr. Minami and his colleagues found that these agonists also turn on a gene that produces Down Sy...
Hold the stuffing: Low-glycemic diet may help keep weight off
...greater improvements in insulin resistance (a risk factor
for diabetes) and serum triglyceride and C-reactive protein levels (risk factors for cardiovascular disease). They now have a long-term study, in a larger group of subjects, to see if people on the low-GL diet can indeed keep off the lost pounds. Dr....
A new species of amyloid peptide
...ursor protein may function as a receptor or growth factor
precursor," notes Dr. Xuemin Xu of The University of Tennessee. "Recent studies also suggest that the intracellular C-terminal domain of the amyloid precursor protein may function as a transcription factor." While the exact pathogenic role of amyloid...
New findings in innate immunity may lead to treatments for atherosclerosis
...ndant role in regulating the nuclear transcription factor
NFκB and the expression of pro-inflammatory cytokines such as IL-1beta and TNFalpha." However, mice that lack IRAK1 can still activate NFκB, suggesting that IRAK1 may be involved in other activities. Dr. Li and his colleagues discovered tha...
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