DNA sequence controls expression of gene involved in cancer
...h or apoptosis. This protein keeps death-promoting factors from producing holes in the mitochondria which can result in calcium and destructive proteins leaking out into the cell. However, the overexpression of bcl-2 in damaged cells can lead to the continued division of the mutated cells and eventually canc...Commandeering cellular machinery: recognition mechanism to detect small molecules
...clear receptors are ligand-activated transcription factors contained in cells. When activated by specific small molecules, the nuclear receptors initiate a complex process that results in gene expression. Because these receptors play a vital role in controlling cellular response to these small molecules, sc...September/October 2004 Annals of Family Medicine tip sheet
...mination Survey and for whom ascertainment of risk factors and 10-year status was available. The authors point out that the risk associated with low education level is comparable in magnitude to many of the traditional risk factors, including cholesterol level, smoking status, sex and age, which are included...Most promising clinical uses for stem cells from fat agreed on by international society
... they differentiate into other cell types and what factors they secrete. In developing its consensus, the society focused on three main areas, with separate sessions addressing each. Leading discussions that addressed the biology of the cells was Patricia Zuk, Ph.D., research director, Regenerative Bio...Is Interleukin-6 the 'holy grail' of exercise mediation?
...arance of IL-6 into circulation depends on several factors including exercise intensity, duration and mode. For instance, vigorous rowing doubles the amount of IL-6 in plasma relatively quickly, while in endurance activity IL-6 doesn't appear until later. Activation of the IL-6 gene seems to be enhanced when...New study will tackle three major killer diseases
...ere is less variety in occupations, diet and other factors compared with most other areas of Scotland. The st...t in Edinburgh to understand the impact of genetic factors on the development of the three diseases. Lead investigator Dr Jim Wilson of Public Health Sciences...Biologists ID molecular block for social 'cheaters'
... to control gene expression. Because transcription factors often control more than one gene, we believe the absence of dimA may be interfering with an unknown recognition pathway that is essential for spore selection." The results are the first published by a unique Rice-Baylor collaborative that won $5 mill...New genetic tools provide clues to the effects of exercise and diet on obesity, diabetes
...ular basis for the improvement in several CVD risk factors associated with the metabolic syndrome and the importance of skeletal muscle in governing these changes." The researchers also included William E. Kraus (Center for Living Lab, Duke University Medical Center), Joseph A. Houmard (Human Performan...Muscle-building hand-grips aid systolic blood pressure, carotid AD, endothelial function
...sought to confirm earlier findings related to risk factors for cardiovascular disease (CVD), as well as to uncover some of the underlying mechanisms. Both studies used similar methodology and isometric handgrip (IHG) exercise three times a week for eight weeks at 30% of maximal voluntary contraction. IHG's...Bugs in the gut could play key role in understanding human disease and drug toxicity
...ach other, mammalian genes and other environmental factors to understand why some drugs work well in some people but not others. Professor Nicholson adds: "Understanding the man-microbe interaction is likely to be crucial in realising personalised medicine and healthcare in the future."...Toward a better understanding of taste and smell impairments
...ed. "By investigating the role of inflammatory factors in chemosensory loss and recovery, we expect to gain insight into potential therapeutic interventions for these dysfunctions," says Beverly Cowart, Ph.D., a sensory psychologist who oversees the Chemosensory Clinic that assesses taste and smell fun...New risks for bladder cancer identified by MIT team
...colleagues have identified three new chemical risk factors for bladder cancer in a study involving some 600 p...w carcinogens, however, were also found to be risk factors for bladder cancer in nonsmokers. Although second-hand smoke is one source of exposure for non-smoke...Experts present new research on hot topics in aging at GSA's annual meeting in Washington, DC
...erforming ADL, was designed to assess whether risk factors for functional decline were similar in Blacks and ... has established that both familial and life style factors are important predictors of longevity. This symposium will shed additional light on personal and fam...Embryonic stem cells correct congenital heart defect in mouse embryos
...e embryonic heart but also by releasing biological factors into the nearby vicinity. This prevented neighboring heart cells from developing into defective tissue. "In other words, stem cells act like nurses, restoring 'sick' cells to health" said Robert Benezra, Ph.D., a Member in the Cancer Biology and Ge...Researchers provide road map for generating B cells from stem cells
... signals later on. For example, the transcription factors PU.1 and lkaros are crucial early in the process, nudging a multi-potent progenitor cell -- stage 1, which could become any type of blood cell -- toward becoming a lymphoid progenitor, stage 2. They trigger the expression of certain receptors on the...FSU scientist links iron imbalance to Parkinson's disease
...e problems, both in healthy rodents and where risk factors existed. High levels of iron caused Parkinson's...ymptoms even in healthy mice without apparent risk factors for the illness, while accelerating the decline and death of those already diagnosed with the diseas...Estrogen protects male rats from aortic aneurysms
... of surgery in the U-M Medical School, who studies factors responsible for gender differences in abdominal ao...." Scientists in Upchurch's lab are studying other factors involved in AAAs, including how tamoxifen, a drug used to treat breast cancer, affects the process o...Study in Royal Society journals presents evidence for inherited factors in homosexuality
...gical Sciences Evidence for maternally inherited factors favouring male homosexuality and promoting female ...rom the population. The authors here argue genetic factors could partially explain male homosexuality, and propose a paradox solution: genetic factors favourin...Gladstone researchers resolve key Huntington's disease mystery in Nature cover story
... neurons over time, thus enabling them to identify factors that predict the fate of the cell. "With this new ...ents of whatever we wish, and then determine which factors have prognostic value, whether they predict survival or neurodegeneration, and how strong the predic......activity peaks and aids responses to environmental factors such as seasonal changes in lightness and darkness. Rosbash said that there is evidence that mammals, including humans, also possess such dual circadian systems and that the systems communicate with one another, but researchers have not yet been abl...