Penn researchers discover how microRNAs control protein synthesis
...tify how miRNA-mediated gene expression regulation fails in human diseases. Many studies show that miRNAs are differentially expressed in a wide variety of human cancers and therefore have the potential to be used as diagnostic biomarkers for cancers, says Kiriakidou. Understanding the central role of A...Measuring the unseeable: Penn researchers probe proteins' dark energy
... the entropy component may explain why drug design fails more often than it works. Currently, drugs are designed generally based on the precise structures of their biological targets, active regions on proteins that are intended to inhibit key molecules. However, the number of designed molecules actually b...Adult survivors of childhood leukemia exercise less, worsening high risk for obesity and illness
... week. While more than half of the U.S. population fails to meet CDC recommendations, low physical activity among adult survivors of ALL may further increase this groups already high risk for obesity, cardiovascular disease and mortality, researchers said. Though the addition of CRT to ALL therapy over 4...Einstein researchers' prototype vaccine could provide improved protection against tuberculosis
...ite being the worlds most widely used vaccine, BCG fails to protect adults from TB infection and doesnt reliably stem the reactivation of pulmonary TB (the most common form of the disease) in adults. Virtually all efforts to develop a better TB vaccine have focused on boosting BCGmodifying it to elicit a......l nuclei. On the other hand, gel electrophoresis fails to indicate the severity of the damage, or where in the nucleus the double-strand breaks occur. The default assumption has been that DSBs occur randomly in a homogenous distribution of DNA in the nucleus. Most gel electrophoresis studies indicate ...A unique arrangement for egg cell division
...out the research in Ellenbergs lab, if the spindle fails to accurately segregate the chromosomes this results in diseases like Down syndrome and infertility. It is therefore very important that we now understand how this crucial division at the beginning of life is orchestrated....High blood pressure, low energy -- a recipe for heart failure
... that in high blood pressure conditions, the heart fails because it becomes energy starved. And if you could feed the heart by using a drug that enhances ERR, for example you might enable the heart to better keep pace with its energy requirements." Although preventions and treatments are now available f...Risk of common vaginal infection linked to preterm birth appears higher for blacks
...e of antibiotics. However, in some cases treatment fails and infections become resistant. Even women whose infection clears frequently can become re-infected later. We found that paternal race is an independent risk factor for BV during pregnancy, and that this is at least as important a risk factor as m...Doernbecher Children's Hospital scientist earns coveted Javits award
... "We previously believed that the developing brain fails to make normalmyelin, because the oligo-cells that make the myelin were completelykilled. Hence, it was thought that the children with CP sustainpermanent abnormalities in movement and intellect," Back explained."However, our recent studies suggest t...