Manipulation of epigenome turns off as many genes as it turns on
...e turned off. The findings don't mean automatic failure for clinical trials of so-called demethylation agents, but they do indicate that careful attention should be paid to results of laboratory experiments and clinical trials that use the agents, since so many genes are affected, says Feinberg. "It...Insects implicated in the evolution of new human infectious diseases
...f certain drugs. The researchers predict that the failure of automated hospital diagnostic machines to recognise this unusual bacterium means that many more cases of this new infection may exist. This is likely to be particularly true for the developing world, where doctors may diagnose the sore as a bad ul...Passage of Marin County GMO ban would encourage widespread use of harsh pesticides
...ely does not apply to agricultural research. This failure to exclude agricultural research from the ban will prevent use here of one of the most promising technologies in agricultural research. A review of the scientific literature shows that genetically engineered foods are safe to eat. For example, the N...Fat buildup found in hearts of obese or diabetic heart failure patients
...iabetic or obese patients suffering advanced heart failure have higher levels of fat embedded in their hearts and greater molecular evidence of haywire cardiac metabolism, a research team led by cardiologists at The University of Texas Medical School at Houston reports in the November issue of the FASEB Jour...One-way processes speed degradation of coral reefs
...tructive forces that are hard to reverse---for the failure of most current efforts to halt continuing losses. Birkeland identifies seven ecological ratchets that seem to contribute to the loss of coral reefs, including a decrease of corals' reproductive success that may occur at lower population densities, t...First human trial of bioartificial kidney shows promise for acute renal failure
...ion. Patients were seriously ill, with acute renal failure and multiple other illnesses, including sepsis, mu...l therapy for patients with acute or chronic renal failure involves dialysis or kidney transplant, both of which have limitations. Humes and his colleagues beg...Genetic variant linked to weakened heart pumping
...uld provide a clue to the variability of how heart failure develops in many patients, they said. The research...re." Also known as congestive heart failure, heart failure is a condition characterized by the thickening of the walls of the heart. Over time this thickening ...Duchenne Muscular Dystrophy research focuses on early mechanisms
...udy will help them better understand if the cell's failure to properly control calcium is what leads to the start of Duchenne Muscular Dystrophy. Preliminary work by Grange and his associates has been funded by the Muscular Dystrophy Association and the Thomas and Kate Jeffress Memorial Trust. "Dr. Grange is...UCSD researchers find effective treatment for unusual fever syndrom caused by cold exposure
...nd rash. In severe cases, patients develop kidney failure related to the disorder. A typical FCAS pa...rom the severe form of FCAS that had caused kidney failure in several generations of her family. Since she began injections of anakinra every other day, her s...JCI table of contents, November 15 2004
...e in muscle and liver coupled with the progressive failure of beta cells in the pancreas to produce sufficient quantities of insulin to overcome the increasing resistance. In the November 15 issue of the Journal of Clinical Investigation, a study by Charlotte Ling and colleagues from Lund Univ...Aging affects susceptibility to type 2 diabetes
...e in muscle and liver coupled with the progressive failure of beta cells in the pancreas to produce sufficient quantities of insulin to overcome the increasing resistance. In the November 15 issue of the Journal of Clinical Investigation, a study by Charlotte Ling and colleagues from Lund University, Swed...Study in Royal Society journal on evidence for impact of global warming on bird populations
...distributions is crucial for the prediction of the failure condition of these materials. This study shows that the force distributions can be accurately described by an analogue of the Second Law of Thermodynamics, which governs the directions of changes in thermal systems such as chemical reactions. In ther......dual regions known to be susceptible developmental failure on loss of GFR1 function, such as the kidneys, motor and enteric neurons and certain parts of the central nervous system during development and following injury, showed that Cis-only mice develop and regenerate structures that are both morphologicall......ity has been inadequately appreciated because of a failure to recognize that "high speed is not always important," Bramble says. "What is important is combining reasonable speed with exceptional endurance." Another reason is that "scientists are in developed societies that are highly dependent on technolog...Menssana research at NJIT receives kudos for FDA-approved breath test
...lls fruity because of acetones, patients in kidney failure have breath that smells like urine, and liver disease and lung infections also have distinctive odors." But Phillips' research has taken breath analysis way beyond the sniff test. In February 2004, the federal Food and Drug Administration approved t...How the battle of Waterloo could help doctors fight death from multiple organ failure
...atients recover and others die from multiple organ failure - the number one killer of patients in intensive c...about to embark on a large study of multiple organ failure induced by sepsis, which kills around a third of patients in intensive care. Ultimately, they hope t...Novel AT2R gene transfer prevents hypertension-related enlarged heart, cardiac fibrosis
...lso have therapeutic application in treating heart failure and heart attacks, according to a paper in Physiol...2R provides cardioprotective effects against heart failure and/or myocardial infarction (heart attack). To see if the lentiviral vector system "can be used t...JCI table of contents, December 1 2004
...df Gene therapy rescues the failing heart Heart failure remains a leading cause of death and researchers c...s have been shown to decrease as a result of heart failure in both animals and humans. The authors found that this gene therapy approach restored the levels of...Red wine lovers, take heart: More evidence points to the drink's cardiac heath benefits
... fibrosis. Diseases such as hypertension and heart failure can cause fibrosis, a hardening or stiffening of the heart tissue. This condition arises when heart cells called cardiac fibroblasts are activated. These cells secrete collagen, a protein that provides structural support for the heart. Overactive ...DNA breaks and genomic instability: Broken ends stick together
...unately, the molecular events following DNA repair failure that lead to this genomic instability are only partly understood. In the first study, researchers led by David Toczyski at UCSF and James Haber at Brandeis University fluorescently marked chromosomes at, or near, DNA breaks, and showed that the brok...