Identified mechanism in the malaria parasite to help it adapt to infected individuals
Plasmodium falciparum is responsible for the most severe forms of human ...f invasion. Now, the scientists have found that P. falciparum can activate and deactivate the expression of 7 of these genes (and their corresponding proteins) wi...Congenital diaphragmatic hernia
...op.edu Age and acquired immunity to Plasmodium falciparum John Aponte and colleagues report that reducing...pment of naturally acquired immunity to Plasmodium falciparum and its clinical presentation. PLoS Med 4(7): e242. IN YOUR ARTICLE, PLEASE LINK TO THIS URL, WHIC...CRESIB coordinates an international consortium to fight malaria caused by Plasmodium vivax
...falciparum, P. vivax, P. malariae and P. ovale. P. falciparum and P. vivax are the most prevalent, the first being more virulent and responsible of most of the severe morbidity and mortality. Nevertheless, during the last years, there has been a growing interest in malaria by P. vivax , which, as well as cau...Malaria and Epstein-Barr virus linked to pediatric cancer in Africa
...itutet in Stockholm explain how certain Plasmodium falciparum antigens directly induce Epstein-Barr virus (EBV) reactivation, increasing the risk of Burkitt lymphoma. EBV is a ubiquitous virus that establishes a lifelong persistence following primary infection. How EBV affects its host hinges on a balance ...Largest synthetic gene ever built offers insights into anti-malarial drug resistance
...ly understand how the malarial parasite Plasmodium falciparum (P. falciparum), has become resistant to most of t...es, according to Roepe. Five infect humans, but P. falciparum is responsible for about 1 million deaths out of 300 million acute cases of infection each year. Mos...Antibody-based therapies effective at controlling malaria
...t of fully human antibodies specific to Plasmodium falciparum may be effective at controlling the disease, repor...d using rodent malaria parasites transgenic for P. falciparum antigens in mice and humans. An in vivo mouse model has significant advantage over the use of new wo...Malaria: The right vaccine in the right place?
...ctuated in their study population, but that the P. falciparum 3D7 MSP-119 haplotype was present in only 16% of t...infections. (In contrast, combinations found in P. falciparum FVO and FUP strains were each present in about 40% of the infections.) These findings show that m...Potential for malaria transmission higher than previously thought
...author provides 121 estimates of R0 for Plasmodium falciparum malaria in African populations. In addition to the higher estimates of R0, they also show that in small human populations, R0 approximates transmission when counting infections from mosquito to mosquito, but overestimates it from human to human. Prev...PATH Malaria Vaccine Initiative announces partnership to develop novel malaria vaccine
...from the most deadly malaria parasite, Plasmodium falciparum . MVI and Sanaria will move quickly to conduct an ...very high levels of protection against Plasmodium falciparum . While immunization of humans with attenuated malaria parasites has been considered for 40 years,...Genetic map offers new tool for malaria research
... for the malaria research community." Plasmodium falciparum the deadliest of the four parasites that cause ma... the scientists analyzed more than 50 different P. falciparum samples from diverse geographic locations. This includes the complete genome sequencing of two well-...Malaria: Efficacy of monotherapies in Cameroon
...c parasite of the genus Plasmodium. The species P. falciparum induces the most serious form of this disease. Since the 1980s, African countries where malaria is endemic have been seeing the emergence of parasite forms resistant to the most widely used treatments, especially to chloroquine. Monitoring of the ext...Einstein researchers find 'key' to unlocking world's deadliest malaria parasite
...que for inserting any gene of interest into the P. falciparum genome to gain biological information that could lead to more effective treatments. "This opens up a whole new window into the genetic manipulation of this lethal parasite," says Dr. William Jacobs, who is a Howard Hughes investigator and professo...Study points to genes responsible for malaria parasite's survival in attempts to eradicate it
...fferent field and laboratory strains of Plasmodium falciparum collected from four continents. Of the parasite's ...ntial target highlighted by the research is the P. falciparum GTP cyclohydrolase gene, the first enzyme in the folate biosynthesis pathway. Downstream members of ...Fake malaria drug implicated in Burmese man's death
... was diagnosed as having a straightforward case of falciparum malaria. He was treated with the vital antimalari...ate was given to 600 patients with straightforward falciparum malaria in a study in East Burma, every single patient survived. Newton and colleagues conclude tha...Malaria, potato famine pathogen share surprising trait
...nce of proteins, called the leader sequence, in P. falciparum with the leader sequence of P. infestans. A leader sequence is a group of about 20 to 30 amino acids on a protein secreted by the parasite. This sequence contains instructions on how to enter, and therefore start infecting, a plant or animal cell. In...Scientists lift malaria's cloak of invisibility
...earch scholars in Australia have determined how P. falciparum can turn on one cloaking gene and keep dozens of o...ody has never seen before. In its new disguise, P. falciparum can invade more red blood cells and cause another wave of fever, headaches, nausea, and chills. "It'...New antimalarial combination confirms its potential use in treating drug-resistant malaria
...ting the potential benefits of treating Plasmodium falciparum malaria with a new artemisinin-based combination t...rial of CDA, involving adults and children with P. falciparum malaria, was designed to determine the optimum dose of artesunate in combination with LapdapTM (chlo...New results show the RTS,S malaria vaccine candidate protects children for at least 18 months
...nt less likely to be infected with the Plasmodium falciparum malaria parasite. The participants in the current ...binant protein that fuses a part of the Plasmodium falciparum circumsporozoite protein with the hepatitis B surface antigen and targets immune responses against t...Researchers develop new method to help find deadly malaria parasite's Achilles heel
...ewly discovered protein-interactions in Plasmodium falciparum with protein interactions reported earlier in four...ugs are less and less effective because Plasmodium falciparum has developed resistance to those drugs. Even mosquitoes that transmit malaria are developing resist......e discovery while comparing protein networks of P. falciparum to protein networks in four model organisms: yeast...olleagues looked for conserved networks between P. falciparum and the four model organisms, expecting to find hints about how the parasite operates. "We were hopi...