Tag: "family" at biology news
Study reveals genetic link to colon cancer
...tY human homologue (MYH) gene and there was also a family
history of acquiring the disease then it may accou...f screening and further testing of the patient and family
members is required. This research builds on previous studies that suggest the child of a couple ...
Structure of new DNA enzyme family member found
... group now has nine members of the riboside kinase family
that are thought to have evolved from a common pro...otein family. Ealick explains that even though the family
members don't have appreciable sequence similarity, they all contain three invariable amino acids. T...
Researchers discover transport molecule that allows boron into cells
...1, is found in most tissues and is part of a large family
of ion transporting proteins that allow charged molecules to travel across cell membranes. Ion transporters are embedded in the cell membrane, opening and closing like gates to let charged ions and molecules enter and leave the cell. The movement o...
National Eye Institute funds search for genetic key to corneal disease
... dystrophy and to offer improved diagnosis of this family
of diseases. The $1.1 million, three-year award by the National Eye Institute funds follow-up research on Thiel-Behnke Corneal Dystrophy by principal investigators Richard W.Yee, M.D., clinical professor, and Xinping Zhao, Ph.D., assistant professor,...
New study reveals locations of possible Alzheimer's genes
...nter. "This is a major collection of families, and family
studies really give you more confidence that the region you're looking at is significant." Researchers think that Alzheimer's is caused by the interaction of several different genes, but so far only one gene, ApoE4, has been linked conclusively to th...
Mayo researchers define celecoxib pathways and mechanisms for tumor reduction
...arketed by Pfizer Inc., is a member of the general family
of drugs that target the COX-2, an enzyme that plays a major role in arthritis pain and inflammation. "This COX-2 inhibitor represents a strong option for treatment of breast cancers, and a preventative agent for treatment of individuals with high...
Tiny exosomes extracted from donor cells may be 'magic bullet' for drug-free transplants
..., was then expressed on the cell's surface. As one family
of MHC molecules, MHC-II serves as a beacon for a specific population of T cells called CD4+ T cells. Such cells are activated during chronic rejection in a process associated with the indirect pathway of immune recognition. "This finding is signifi...
Reassuring findings from first study on sperm donor identification
...g their origins with those close to them extended family
members, some friends and a few teachers; In addition to interest in their donor, they expressed interest in contacting other children with the same donor; Those from single mother households were most positive about their DI origins; The pres...
New gene target found for common brain tumors in children
...pathway, since blocking other members of the Notch family
may actually have the opposite effect and encourage cancer growth," says Xing Fan, M.D., Ph.D., first author of the study and postgraduate fellow at Johns Hopkins. In 25 of 30 of the medulloblastomas they studied, Eberhart's team also found low...
Researchers discover molecular timekeeper in bone development
... and bone diseases. HDAC4 belongs to a family
of enzymes that inactivate genes. Unlike other members of this family
which are found in numerous tissues, HDAC4 is expressed in only a few tissues, including bone. ...
By impounding iron, FHC foils cell suicide, fuels inflammation
...n on the self. The researchers focused on NF-kB, a family
of transcription factors -- proteins that turn on or off specific genes. The NF-kB family
plays a crucial role in regulating immune and inflammatory responses to microbial invasion. During ...
UCSD researchers find effective treatment for unusual fever syndrom caused by cold exposure
...grated to the U.S. in the 1600s. FCAS is one of a family
of seven distinct, single-gene defects that are co...studied FCAS by drawing blood samples at different family
reunions held throughout the United States, from Georgia, Ohio, Illinois and Missouri, to Utah and C...
Brain-derived neurotrophic factor (BDNF) appears to modify elements of alcoholism
...le intoxicated, history of alcohol withdrawal, and family
history of alcoholism. The comparison control group consisted of 336 nonalcoholic male subjects. DNA was extracted via blood, and the G196A polymorphism (variant) of the BDNF gene was genotyped. Results indicate that genotype and allele distributio...
World's largest population study on BRCA1/2
... additional factors that account for this residual family
aggregation," said Prof Hemminki, Head of the Department of Molecular Genetic Epidemiology at the German Cancer Research Center and Professor at Karolinska Institutet in Sweden and at the Heidelberg University. Key conclusions from the study: * B...
New findings may redirect strategies for treatment of prostate cancer
...another and are known to enhance AR function, ERBB family
members EGFR and HER2. Previous work has strongly ...ions with EGFR, but by associating with other ERBB family
members. The researchers conclude that AR function is modulated by the HER2/ERBB3 pathway and n...
JCI table of contents, November 15 2004
...ranes as foreign, and attacks them. Desmogleins, a family
of proteins that function to attach one cell to its neighbor, when attacked by autoantobodies, become separated from each other causing burn-like lesions or blisters that do not heal. To date, four types of desmogleins have been described Dsg14 and...
Muscle loss from space travel, prolonged inactivity linked to two genes
...role of nfb1 and bcl3 , two gene members from a family
of transcription factors -- genes that produce proteins that regulate the activities of other genes. Her previous research had shown these transcriptional regulators were implicated in the process of muscle atrophy. By studying strains of mice ...
Genome of ancient fish could reveal evolutionary mysteries, Stanford scientists say
... genetically--since one wayward branch of the fish family
headed for land roughly 360 million years ago. Because it has changed so little the coelacanth is ideal for genetic comparisons. Any genetic feature found in all land animals but lacking in the coelacanth could represent a change that makes living on...
No getting around RET
...ely referred to as neurotrophic factors, include a family
of four GDNF Family Ligands (GFLs) that bind to specific receptor sites on the surfaces of neural cells. These sites allow GFLs to signal through a receptor complex composed of the RET tyrosine kinase and a GFR-family receptor. Tyrosine kinases, such...
Smoking is in the genes
...nds on his or her environment. Smoking friends and family
members increase the chance that someone will take up smoking. Jacqueline Vink discovered that the variation between smokers in the number of cigarettes smoked per day is genetically determined. The same is true for the degree of nicotine dependency....
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