A 'repulsive' protein guides blood vessel development
...d in blood vessel patterning actually belongs to a family of proteins known to guide neural development. The...olecules, Semaphorin 3E (Sema3E), is a member of a family of protein signals that guides the growth of nerve cells. The other protein, plexin-D1, is a recepto...Tips from the Journals of the American Society for Microbiology
...se (I7L) that that is used by orthopoxviruses, the family of viruses that includes smallpox. The model was ...n the results reported here, the chemical compound family represented by TTP-6171 represents a promising avenue toward developing an effective antiviral drug ...New protein structure may aid in design of therapeutics for autoimmune disease
...kinase C (PKC) isozyme, in this case the novel PKC family member PKC theta (PKCΘ). This structure should prove extremely useful in the rational design of small molecule inhibitors of PKCΘ, which has been implicated in T-cell mediated disease processes including inflammation and autoimmunity. The ...New findings in innate immunity may lead to treatments for atherosclerosis
...nvironmental cues and send signals downstream to a family of interleukin-1 receptor associated kinases (IRAKs). These IRAKs then activate and/or regulate specific cytokine gene expression," explains Dr. Liwu Li of the Wake Forest University School of Medicine. However, the specificity of the TLR signaling p...Promising results in the battle against incurable ALS muscle disease
...eriod of their lives - without warning or previous family history. Researchers from VIB (the Flanders Interuniversity Institute for Biotechnology), under the direction of Prof. Peter Carmeliet (Catholic University of Leuven), have previously shown the importance of the VEGF protein in this disease. Now, new...Fussy Baby Network answers cries for help in community
...d to assess the infant, support parents and reduce family stress. "Parents are desperate by the time the...ul cycle. Gilkerson believes early troubles in the family relationship can turn around. "This is a very open time psychologically for the mother," she said. "...JCI table of contents, December 1 2004
...e vessel and, over time, formation of a lesion. A family of proteins known as PPARs (PPARalpha, PPARbeta, a...in mice, the role of other members of this protein family have remained unclear. In the December 1 issue of the Journal of Clinical Investigation, Andrew Li a...Study gives US a 'C' for lagging support of international reproductive health and population efforts
...cess to basic reproductive health care - including family planning and HIV/AIDS prevention and treatment ser...is that when women are supported by investments in family planning and related programs, families are lifted out of poverty." But fulfilling commitments requi...Multidrug-resitant bacteria found to be airborne in concentrated swine operation
...s of drug-resistant bacteria that can be spread to family and the broader community. The study also raises questions about the spread of drug-resistant bacteria to areas beyond the immediate site through ventilation fans and by the application of manure from feeding operations to off-site fields. "These res...New drug sidesteps Gleevec resistance in human trials
...at Abl looks structurally quite similar to the Src family of oncogenes that also produce kinases. Yet, as Kuriyan's work demonstrated, STI-571 does not inhibit the Src proteins because they maintain a different shape when in their inactivated, or "off," position. As Kuriyan prophetically stated at the time,...Draft sequence of chicken genome completed
...mmon: for example, mammals have expanded a certain family of keratins for hair production, whereas birds use a different set for the formation of feathers and claws. We also found some chicken genes involved in immune function that previously were believed to be unique to humans." An international consortiu...Researchers compare chicken, human genomes
...ers determined that chickens have an expanded gene family coding for a type of keratin protein used to produ...ompared with mammals, chickens have a much smaller family of genes coding for taste receptors, particularly those involved in detecting bitter sensations. Oth...Canola study solves seed oil mystery
...anola (or rapeseed), an annual crop in the mustard family that is widely cultivated throughout the upper Midwest, Canada, Europe and Asia. The oil extracted from the seeds of this plant is used to make everything from margarine to industrial lubricants. Seeds store large oil reserves to use as energ...New tuberculosis antibiotic may shorten treatment time, fight drug-resistant strains
...tuberculosis," Andries said. The drug belongs to a family of compounds called "diarylquinolines," or "DARQs"...hnson & Johnson. The research team identified this family by screening a large number of compounds from its chemical "library" to see what effects the compoun...Genetic defect confers risk of major depression, resistance to SSRI drug therapy
...pression who carried the defective gene also had a family history of mental illness or drug and alcohol abus...cluding generalized anxiety, mild depression and a family history of mental illness or drug and alcohol abuse -- further suggesting a higher susceptibility fo...Cloned gene from sea animal may prove key in cancer drug development
... Bugula neritina were the source of bryostatins, a family of chemical compounds being closely studied for their potential asanticancer pharmaceuticals in leukemia, lymphoma and several cancers including colon, breast, ovarian and prostate. One of the main obstacles impeding widespread bryostatin production ...Baby songbirds and human infants learn sounds in similar ways
...song by analyzing song-learning with birds kept in family groups rather than in isolation chambers. The Rock...t the same age. The researchers propose that in a family setting, a young zebra finch chooses a strategy different from that of his siblings, perhaps to bett...Dwarf mistletoe reveals its sexual secrets
...he dwarf mistletoe, a member of the same Viscaceae family as the better-known Christmas varieties, is truly worthy of being hung with pride. The stubby variety might be a clumpy green parasite of conifers, but it turns out to have the world's only water-pump seed ejection system. One that can fire a seed up...Mutant gene linked to treatment-resistant depression
... nine SSRI-resistant patient carriers, seven had a family history of mental illness or substance abuse, six ...ression, the three control group carriers also had family histories of psychiatric problems and experienced mild depression and anxiety symptoms. This points...UT Southwestern researchers locate gene family involved in determining potential for acquiring lupus
...western Medical Center at Dallas have found a gene family involved in determining the potential for acquirin...ic combinations with other genes. "The SLAM/CD2 family interacts with sets of highly variable genes, which can provide a pathway toward disease," said Dr. ...