Genes tied to abnormal immune response in mice with lupus
Scientists have uncovered a link between a family of genes and abnormalities of the immune system th...ion of a subset of genes belonging to the SLAM/CD2 family may contribute to autoimmunity in mice with lupus. Scientists have known for some time that SLAM/CD...A genetic difference at the opiate receptor gene affects a person's response to alcohol
...hol's effects as well as a greater likelihood of a family history of alcohol-use disorders. Previous resear...hol's effects as well as a greater likelihood of a family history of alcohol-use disorders. "Alcohol releases endogenous opiates which, in turn, seem to infl...New route to Parkinson's found in cells' 'garbage disposal' system
...he folding of misfolded proteins. BAG5 is one of a family of BAG proteins known to interact with other proteins to aid a variety of cell processes. The structure of BAG5 led Lozano and colleagues to explore whether it might play a role in the proteasome, along with parkin and Hsp70. Their experiments reveal...JCI table of contents, December 15 2004
...producing hepatocyte (Eph) kinases are the largest family of receptor tyrosine kinases in the immune system. The Eph kinases and their ligands are known to direct neural outgrowth, the growth of new blood vessels, and epithelial cell migration in the intestine. In the December 15 issue of the Journal of C......ious revival movements and new forms of social and family interaction. Her research is currently concentrated on the question of how the social order of ranks and classes in the early modern era were constituted through symbolic acts, for instance rituals and ceremonies. Barbara Stollberg-Rilinger always e...Hummingbirds lose power at high altitudes
... The PNAS paper also includes the most complete family tree of hummingbirds ever produced, representing 7...ations, you have to account for the phylogeny the family tree that shows you how species are related to one another," said coauthor Jimmy A. McGuire, assista...Encouraging results of gene therapy for severe combined immunodeficiency
...ast follow up, all patients were at home in normal family and social environments, without restrictions on activities or exposure." An accompanying commentary (p 2155) by Marina Cavazzana-Calvo and Alain Fischer (Hpital Necker-Enfants Malades, Paris, France) discusses all clinical research done in this fiel...Screening for genetic disorders: Need to avoid anxiety
...n that other potentially vulnerable members of the family will be alerted. People picked out as being at risk, but who did not yet have any symptoms, were not unduly anxious about their health, provided they felt they were being monitored and looked after. As a result, they often did not feel the need to pa...Solving the mechanism of Rett Syndrome
... the expression of other, related genes in the DLX family with consequences for the development of the brain. Absent or defective MeCP2 allows increased expression of the DLX5 gene through the loss of a loop of silent chromatin, and the activation of additional neighboring chromatin. This dramat...Genetic predisposition can play an important role in development of lung cancer
...at this familial factor extends beyond the nuclear family as evidenced by significantly increased RR for second- and third-degree relatives of patients with lung carcinoma. In the more distant relationships, shared environmental factors are likely to be of less significance, providing a stronger evidence fo...'Jumping gene' helps explain immune system's abilities
...on different proteins might have originated from a family of genes whose only apparent function is to jump a...cousins, the Hermes protein still has an important family trait, the researchers report. Colleagues at the National Institutes of Health found that a few key ......s drawn to Nedd4 (a member of the ubiquitin ligase family of molecules that directly bind to proteins marked for degradation), as it had previously been shown that Nedd4 plays a role in the processing of other types of transmembrane proteins. Proteins in the cell membrane must first be internalized through ...Vollum Institute discovery may unlock human genome
..., Ph.D., in Goodman's laboratory to characterize a family of genes regulated by the "cAMP response element binding" protein, or CREB. This well-characterized molecule is among a group of proteins called transcription factors that interact with regulatory elements in DNA that are responsible for increasing o...Urban ecology study witnessing the birth of a 'designer ecosystem'
... plants in the Phoenix area is related strongly to family income -- higher family income, higher plant diversity; lower family income, lower plant diversity. We don't know the mechan...JCI table of contents, 3 January 2005
...PDGF-CC is a recently-discovered member of a large family of factors that promote the growth of new blood vessels. However little is known about how this new member functions. In the January 3 issue of the Journal of Clinical Investigation, Peter Carmeliet and colleagues from the University of Leuven show t...Genome comparison of four campylobacter strains yields new genetic markers and clues to virulence
...ave developed a blueprint for the analysis of this family of bacteria," says Derrick Fouts, a scientist at The Institute for Genomic Research (TIGR) who is the first author of the PLoS paper. "This study lays the foundation for further research that may help scientists find new ways to detect and control th...Mothers speak: Physicians often fall short when delivering a down syndrome diagnosis
...s going to bring great richness and warmth to your family and community"; "Your child should be loved just like any other child"; "Your child will teach you and others life lessons"; "Your child will be a beacon of what humanity is supposed to stand for." Based on the mothers' comments, Skotko offers a 10-p...DNA movement linked to formation of antibody genes
...r describes the mechanism by which a member of one family of transposable elements actually moves. This elem...comes from the housefly and is a member of the hAT family of transposable elements that includes the Ac element of maize, which Geneticist Barbara McClintock,...New method simplifies search for genetic changes associated with disease
... selection that accelerates the transition between family or population-based studies of disease inheritance patterns and identification of genetic variations that may contribute to disease. That transition normally slows down dramatically when scientists have to sequence regions of interest in patients' DN...New family of genes could serve as a potential cancer marker
A new family of genes called Novel Structure Proteins (NSP) dis...o says that their initial analysis shows that this family of genes sits mostly in the nucleus of our cells and exhibits the characteristics of a tumor-promoti...